Complex Variant t(9;22) Chromosome Translocations in Five Cases of Chronic Myeloid Leukemia
The Philadelphia (Ph1) chromosome arising from the reciprocal t(9;22) translocation is found in more than 90% of chronic myeloid leukemia (CML) patients and results in the formation of the chimeric fusion gene BCR-ABL. However, a small proportion of patients with CML have simple or complex varia...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2009/187125 |
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| author | Ana Valencia José Cervera Esperanza Such Eva Barragán Pascual Bolufer Oscar Fuster Rosa Collado Jesús Martínez Miguel A. Sanz |
| author_facet | Ana Valencia José Cervera Esperanza Such Eva Barragán Pascual Bolufer Oscar Fuster Rosa Collado Jesús Martínez Miguel A. Sanz |
| author_sort | Ana Valencia |
| collection | DOAJ |
| description | The Philadelphia (Ph1) chromosome arising from the reciprocal t(9;22)
translocation is found in more than 90% of chronic myeloid
leukemia (CML) patients and results in the formation of the
chimeric fusion gene BCR-ABL. However, a small
proportion of patients with CML have simple or complex variants of
this translocation, involving various breakpoints in addition to
9q34 and 22q11. We report five CML cases carrying variant Ph
translocations involving both chromosomes 9 and 22 as well as
chromosomes 3, 5, 7, 8, or 10. G-banding showed a reciprocal
three-way translocation involving 3q21, 5q31, 7q32, 8q24, and 10q22
bands. BCR-ABL fusion signal on der(22) was found
in all of the cases by FISH. |
| format | Article |
| id | doaj-art-1f134c0f13f44c348e7ea4c8130e99c3 |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-1f134c0f13f44c348e7ea4c8130e99c32025-02-03T06:47:23ZengWileyAdvances in Hematology1687-91041687-91122009-01-01200910.1155/2009/187125187125Complex Variant t(9;22) Chromosome Translocations in Five Cases of Chronic Myeloid LeukemiaAna Valencia0José Cervera1Esperanza Such2Eva Barragán3Pascual Bolufer4Oscar Fuster5Rosa Collado6Jesús Martínez7Miguel A. Sanz8Department of Hematology, La Fe University Hospital, 46009 Valencia, SpainDepartment of Hematology, La Fe University Hospital, 46009 Valencia, SpainDepartment of Hematology, La Fe University Hospital, 46009 Valencia, SpainMolecular Biology Laboratory, Department of Medical Biopathology, La Fe University Hospital, 46009 Valencia, SpainMolecular Biology Laboratory, Department of Medical Biopathology, La Fe University Hospital, 46009 Valencia, SpainMolecular Biology Laboratory, Department of Medical Biopathology, La Fe University Hospital, 46009 Valencia, SpainDepartment of Hematology, Hospital General Universitario de Valencia, 46014 Valencia, SpainDepartment of Hematology, La Fe University Hospital, 46009 Valencia, SpainDepartment of Hematology, La Fe University Hospital, 46009 Valencia, SpainThe Philadelphia (Ph1) chromosome arising from the reciprocal t(9;22) translocation is found in more than 90% of chronic myeloid leukemia (CML) patients and results in the formation of the chimeric fusion gene BCR-ABL. However, a small proportion of patients with CML have simple or complex variants of this translocation, involving various breakpoints in addition to 9q34 and 22q11. We report five CML cases carrying variant Ph translocations involving both chromosomes 9 and 22 as well as chromosomes 3, 5, 7, 8, or 10. G-banding showed a reciprocal three-way translocation involving 3q21, 5q31, 7q32, 8q24, and 10q22 bands. BCR-ABL fusion signal on der(22) was found in all of the cases by FISH.http://dx.doi.org/10.1155/2009/187125 |
| spellingShingle | Ana Valencia José Cervera Esperanza Such Eva Barragán Pascual Bolufer Oscar Fuster Rosa Collado Jesús Martínez Miguel A. Sanz Complex Variant t(9;22) Chromosome Translocations in Five Cases of Chronic Myeloid Leukemia Advances in Hematology |
| title | Complex Variant t(9;22) Chromosome Translocations in Five Cases of Chronic Myeloid Leukemia |
| title_full | Complex Variant t(9;22) Chromosome Translocations in Five Cases of Chronic Myeloid Leukemia |
| title_fullStr | Complex Variant t(9;22) Chromosome Translocations in Five Cases of Chronic Myeloid Leukemia |
| title_full_unstemmed | Complex Variant t(9;22) Chromosome Translocations in Five Cases of Chronic Myeloid Leukemia |
| title_short | Complex Variant t(9;22) Chromosome Translocations in Five Cases of Chronic Myeloid Leukemia |
| title_sort | complex variant t 9 22 chromosome translocations in five cases of chronic myeloid leukemia |
| url | http://dx.doi.org/10.1155/2009/187125 |
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