Assessing Errors Inherent in OCT-Derived Macular Thickness Maps
SD-OCT has become an essential tool for evaluating macular pathology; however several aspects of data collection and analysis affect the accuracy of retinal thickness measurements. Here we evaluated sampling density, scan centering, and axial length compensation as factors affecting the accuracy of...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2011/692574 |
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| author | Daniel Odell Adam M. Dubis Jackson F. Lever Kimberly E. Stepien Joseph Carroll |
| author_facet | Daniel Odell Adam M. Dubis Jackson F. Lever Kimberly E. Stepien Joseph Carroll |
| author_sort | Daniel Odell |
| collection | DOAJ |
| description | SD-OCT has become an essential tool for evaluating macular pathology; however several aspects of data collection and analysis affect the accuracy of retinal thickness measurements. Here we evaluated sampling density, scan centering, and axial length compensation as factors affecting the accuracy of macular thickness maps. Forty-three patients with various retinal pathologies and 113 normal subjects were imaged using Cirrus HD-OCT. Reduced B-scan density was associated with increased interpolation error in ETDRS macular thickness plots. Correcting for individual differences in axial length revealed modest errors in retinal thickness maps, while more pronounced errors were observed when the ETDRS plot was not positioned at the center of the fovea (which can occur as a result of errant fixation). Cumulative error can exceed hundreds of microns, even under “ideal observer” conditions. This preventable error is particularly relevant when attempting to compare macular thickness maps to normative databases or measuring the area or volume of retinal features. |
| format | Article |
| id | doaj-art-1f0edcd2618642e49262d4b1e703b9a2 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-1f0edcd2618642e49262d4b1e703b9a22025-02-03T01:02:19ZengWileyJournal of Ophthalmology2090-004X2090-00582011-01-01201110.1155/2011/692574692574Assessing Errors Inherent in OCT-Derived Macular Thickness MapsDaniel Odell0Adam M. Dubis1Jackson F. Lever2Kimberly E. Stepien3Joseph Carroll4Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, WI 53226, USADepartment of Cell Biology, Neurobiology, & Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USADepartment of Ophthalmology, William Beaumont Hospital, Royal Oak, MI 48073, USADepartment of Ophthalmology, Medical College of Wisconsin, Milwaukee, WI 53226, USADepartment of Ophthalmology, Medical College of Wisconsin, Milwaukee, WI 53226, USASD-OCT has become an essential tool for evaluating macular pathology; however several aspects of data collection and analysis affect the accuracy of retinal thickness measurements. Here we evaluated sampling density, scan centering, and axial length compensation as factors affecting the accuracy of macular thickness maps. Forty-three patients with various retinal pathologies and 113 normal subjects were imaged using Cirrus HD-OCT. Reduced B-scan density was associated with increased interpolation error in ETDRS macular thickness plots. Correcting for individual differences in axial length revealed modest errors in retinal thickness maps, while more pronounced errors were observed when the ETDRS plot was not positioned at the center of the fovea (which can occur as a result of errant fixation). Cumulative error can exceed hundreds of microns, even under “ideal observer” conditions. This preventable error is particularly relevant when attempting to compare macular thickness maps to normative databases or measuring the area or volume of retinal features.http://dx.doi.org/10.1155/2011/692574 |
| spellingShingle | Daniel Odell Adam M. Dubis Jackson F. Lever Kimberly E. Stepien Joseph Carroll Assessing Errors Inherent in OCT-Derived Macular Thickness Maps Journal of Ophthalmology |
| title | Assessing Errors Inherent in OCT-Derived Macular Thickness Maps |
| title_full | Assessing Errors Inherent in OCT-Derived Macular Thickness Maps |
| title_fullStr | Assessing Errors Inherent in OCT-Derived Macular Thickness Maps |
| title_full_unstemmed | Assessing Errors Inherent in OCT-Derived Macular Thickness Maps |
| title_short | Assessing Errors Inherent in OCT-Derived Macular Thickness Maps |
| title_sort | assessing errors inherent in oct derived macular thickness maps |
| url | http://dx.doi.org/10.1155/2011/692574 |
| work_keys_str_mv | AT danielodell assessingerrorsinherentinoctderivedmacularthicknessmaps AT adammdubis assessingerrorsinherentinoctderivedmacularthicknessmaps AT jacksonflever assessingerrorsinherentinoctderivedmacularthicknessmaps AT kimberlyestepien assessingerrorsinherentinoctderivedmacularthicknessmaps AT josephcarroll assessingerrorsinherentinoctderivedmacularthicknessmaps |