Safety Profile and Effects of Pulsed Methylprednisolone on Vital Signs in Thyroid Eye Disease
Objective. To analyze changes in vital signs (heart rate (HR), systolic (SBP), and diastolic blood pressure (DBP)) during and after intravenous methylprednisolone (IVMP) and any other adverse effects. Methods. Retrospective review of charts of patients who received IVMP as treatment regime for thyro...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/457123 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832568340289159168 |
|---|---|
| author | Kai-Ling Yong Chiaw Ling Chng Hla Myint Htoon Lee Hooi Lim Lay Leng Seah |
| author_facet | Kai-Ling Yong Chiaw Ling Chng Hla Myint Htoon Lee Hooi Lim Lay Leng Seah |
| author_sort | Kai-Ling Yong |
| collection | DOAJ |
| description | Objective. To analyze changes in vital signs (heart rate (HR), systolic (SBP), and diastolic blood pressure (DBP)) during and after intravenous methylprednisolone (IVMP) and any other adverse effects. Methods. Retrospective review of charts of patients who received IVMP as treatment regime for thyroid eye disease. All subjects had vital signs charted during and after infusions. Results. This study included 38 subjects and a total of 242 infusions administered. IVMP resulted in a small but significant percentage drop in mean SBP at 30 min (p<0.001) and 60 min (p=0.03) but no difference at 90 min. There was also small but significant percentage drop in mean DBP and HR (DBP: p<0.001 for 30 min, p=0.001 for 60 min, and p=0.02 for 90 min and HR: p<0.001 for 30 min, 60 min, and 90 min). There were no cumulative effects on change of blood pressure or HR. There were 6 episodes of bradycardia (2.5%) and 12 episodes of moderate to severe hypertension (5%). No significant cardiovascular or hepatic toxicity was found. Conclusion. IVMP is relatively safe and efficacious. IVMP demonstrated mild and noncumulative effects on vital signs. Severe hypertension may occur in susceptible individuals such as those with underlying hypertension and uncontrolled thyroid dysfunction, whereas bradycardia may be more likely in those on beta-blockers. |
| format | Article |
| id | doaj-art-1f0ab921346948c7b5694bd6ce043f53 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-1f0ab921346948c7b5694bd6ce043f532025-02-03T00:59:12ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/457123457123Safety Profile and Effects of Pulsed Methylprednisolone on Vital Signs in Thyroid Eye DiseaseKai-Ling Yong0Chiaw Ling Chng1Hla Myint Htoon2Lee Hooi Lim3Lay Leng Seah4Singapore National Eye Centre, 11 Third Hospital Avenue, 168751, SingaporeSingapore General Hospital, Outram Road, 169608, SingaporeSingapore Eye Research Institute, 11 Third Hospital Avenue, 168751, SingaporeSingapore National Eye Centre, 11 Third Hospital Avenue, 168751, SingaporeSingapore National Eye Centre, 11 Third Hospital Avenue, 168751, SingaporeObjective. To analyze changes in vital signs (heart rate (HR), systolic (SBP), and diastolic blood pressure (DBP)) during and after intravenous methylprednisolone (IVMP) and any other adverse effects. Methods. Retrospective review of charts of patients who received IVMP as treatment regime for thyroid eye disease. All subjects had vital signs charted during and after infusions. Results. This study included 38 subjects and a total of 242 infusions administered. IVMP resulted in a small but significant percentage drop in mean SBP at 30 min (p<0.001) and 60 min (p=0.03) but no difference at 90 min. There was also small but significant percentage drop in mean DBP and HR (DBP: p<0.001 for 30 min, p=0.001 for 60 min, and p=0.02 for 90 min and HR: p<0.001 for 30 min, 60 min, and 90 min). There were no cumulative effects on change of blood pressure or HR. There were 6 episodes of bradycardia (2.5%) and 12 episodes of moderate to severe hypertension (5%). No significant cardiovascular or hepatic toxicity was found. Conclusion. IVMP is relatively safe and efficacious. IVMP demonstrated mild and noncumulative effects on vital signs. Severe hypertension may occur in susceptible individuals such as those with underlying hypertension and uncontrolled thyroid dysfunction, whereas bradycardia may be more likely in those on beta-blockers.http://dx.doi.org/10.1155/2015/457123 |
| spellingShingle | Kai-Ling Yong Chiaw Ling Chng Hla Myint Htoon Lee Hooi Lim Lay Leng Seah Safety Profile and Effects of Pulsed Methylprednisolone on Vital Signs in Thyroid Eye Disease International Journal of Endocrinology |
| title | Safety Profile and Effects of Pulsed Methylprednisolone on Vital Signs in Thyroid Eye Disease |
| title_full | Safety Profile and Effects of Pulsed Methylprednisolone on Vital Signs in Thyroid Eye Disease |
| title_fullStr | Safety Profile and Effects of Pulsed Methylprednisolone on Vital Signs in Thyroid Eye Disease |
| title_full_unstemmed | Safety Profile and Effects of Pulsed Methylprednisolone on Vital Signs in Thyroid Eye Disease |
| title_short | Safety Profile and Effects of Pulsed Methylprednisolone on Vital Signs in Thyroid Eye Disease |
| title_sort | safety profile and effects of pulsed methylprednisolone on vital signs in thyroid eye disease |
| url | http://dx.doi.org/10.1155/2015/457123 |
| work_keys_str_mv | AT kailingyong safetyprofileandeffectsofpulsedmethylprednisoloneonvitalsignsinthyroideyedisease AT chiawlingchng safetyprofileandeffectsofpulsedmethylprednisoloneonvitalsignsinthyroideyedisease AT hlamyinthtoon safetyprofileandeffectsofpulsedmethylprednisoloneonvitalsignsinthyroideyedisease AT leehooilim safetyprofileandeffectsofpulsedmethylprednisoloneonvitalsignsinthyroideyedisease AT laylengseah safetyprofileandeffectsofpulsedmethylprednisoloneonvitalsignsinthyroideyedisease |