Mitochondrial Dysfunction: A Basic Mechanism in Inflammation-Related Non-Communicable Diseases and Therapeutic Opportunities

Obesity is not necessarily a predisposing factor for disease. It is the handling of fat and/or excessive energy intake that encompasses the linkage of inflammation, oxidation, and metabolism to the deleterious effects associated with the continuous excess of food ingestion. The roles of cytokines an...

Full description

Saved in:
Bibliographic Details
Main Authors: Anna Hernández-Aguilera, Anna Rull, Esther Rodríguez-Gallego, Marta Riera-Borrull, Fedra Luciano-Mateo, Jordi Camps, Javier A. Menéndez, Jorge Joven
Format: Article
Language:English
Published: Wiley 2013-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2013/135698
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832552758269444096
author Anna Hernández-Aguilera
Anna Rull
Esther Rodríguez-Gallego
Marta Riera-Borrull
Fedra Luciano-Mateo
Jordi Camps
Javier A. Menéndez
Jorge Joven
author_facet Anna Hernández-Aguilera
Anna Rull
Esther Rodríguez-Gallego
Marta Riera-Borrull
Fedra Luciano-Mateo
Jordi Camps
Javier A. Menéndez
Jorge Joven
author_sort Anna Hernández-Aguilera
collection DOAJ
description Obesity is not necessarily a predisposing factor for disease. It is the handling of fat and/or excessive energy intake that encompasses the linkage of inflammation, oxidation, and metabolism to the deleterious effects associated with the continuous excess of food ingestion. The roles of cytokines and insulin resistance in excessive energy intake have been studied extensively. Tobacco use and obesity accompanied by an unhealthy diet and physical inactivity are the main factors that underlie noncommunicable diseases. The implication is that the management of energy or food intake, which is the main role of mitochondria, is involved in the most common diseases. In this study, we highlight the importance of mitochondrial dysfunction in the mutual relationships between causative conditions. Mitochondria are highly dynamic organelles that fuse and divide in response to environmental stimuli, developmental status, and energy requirements. These organelles act to supply the cell with ATP and to synthesise key molecules in the processes of inflammation, oxidation, and metabolism. Therefore, energy sensors and management effectors are determinants in the course and development of diseases. Regulating mitochondrial function may require a multifaceted approach that includes drugs and plant-derived phenolic compounds with antioxidant and anti-inflammatory activities that improve mitochondrial biogenesis and act to modulate the AMPK/mTOR pathway.
format Article
id doaj-art-1f090301a4f7462baf413763c449b6f5
institution Kabale University
issn 0962-9351
1466-1861
language English
publishDate 2013-01-01
publisher Wiley
record_format Article
series Mediators of Inflammation
spelling doaj-art-1f090301a4f7462baf413763c449b6f52025-02-03T05:57:47ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/135698135698Mitochondrial Dysfunction: A Basic Mechanism in Inflammation-Related Non-Communicable Diseases and Therapeutic OpportunitiesAnna Hernández-Aguilera0Anna Rull1Esther Rodríguez-Gallego2Marta Riera-Borrull3Fedra Luciano-Mateo4Jordi Camps5Javier A. Menéndez6Jorge Joven7Unitat de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, carrer Sant Llorenç 21, 43201 Reus, SpainUnitat de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, carrer Sant Llorenç 21, 43201 Reus, SpainUnitat de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, carrer Sant Llorenç 21, 43201 Reus, SpainUnitat de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, carrer Sant Llorenç 21, 43201 Reus, SpainUnitat de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, carrer Sant Llorenç 21, 43201 Reus, SpainUnitat de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, carrer Sant Llorenç 21, 43201 Reus, SpainCatalan Institute of Oncology and Girona Biomedical Research Institute, Avda de Francia s/n, 1707 Girona, SpainUnitat de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, carrer Sant Llorenç 21, 43201 Reus, SpainObesity is not necessarily a predisposing factor for disease. It is the handling of fat and/or excessive energy intake that encompasses the linkage of inflammation, oxidation, and metabolism to the deleterious effects associated with the continuous excess of food ingestion. The roles of cytokines and insulin resistance in excessive energy intake have been studied extensively. Tobacco use and obesity accompanied by an unhealthy diet and physical inactivity are the main factors that underlie noncommunicable diseases. The implication is that the management of energy or food intake, which is the main role of mitochondria, is involved in the most common diseases. In this study, we highlight the importance of mitochondrial dysfunction in the mutual relationships between causative conditions. Mitochondria are highly dynamic organelles that fuse and divide in response to environmental stimuli, developmental status, and energy requirements. These organelles act to supply the cell with ATP and to synthesise key molecules in the processes of inflammation, oxidation, and metabolism. Therefore, energy sensors and management effectors are determinants in the course and development of diseases. Regulating mitochondrial function may require a multifaceted approach that includes drugs and plant-derived phenolic compounds with antioxidant and anti-inflammatory activities that improve mitochondrial biogenesis and act to modulate the AMPK/mTOR pathway.http://dx.doi.org/10.1155/2013/135698
spellingShingle Anna Hernández-Aguilera
Anna Rull
Esther Rodríguez-Gallego
Marta Riera-Borrull
Fedra Luciano-Mateo
Jordi Camps
Javier A. Menéndez
Jorge Joven
Mitochondrial Dysfunction: A Basic Mechanism in Inflammation-Related Non-Communicable Diseases and Therapeutic Opportunities
Mediators of Inflammation
title Mitochondrial Dysfunction: A Basic Mechanism in Inflammation-Related Non-Communicable Diseases and Therapeutic Opportunities
title_full Mitochondrial Dysfunction: A Basic Mechanism in Inflammation-Related Non-Communicable Diseases and Therapeutic Opportunities
title_fullStr Mitochondrial Dysfunction: A Basic Mechanism in Inflammation-Related Non-Communicable Diseases and Therapeutic Opportunities
title_full_unstemmed Mitochondrial Dysfunction: A Basic Mechanism in Inflammation-Related Non-Communicable Diseases and Therapeutic Opportunities
title_short Mitochondrial Dysfunction: A Basic Mechanism in Inflammation-Related Non-Communicable Diseases and Therapeutic Opportunities
title_sort mitochondrial dysfunction a basic mechanism in inflammation related non communicable diseases and therapeutic opportunities
url http://dx.doi.org/10.1155/2013/135698
work_keys_str_mv AT annahernandezaguilera mitochondrialdysfunctionabasicmechanismininflammationrelatednoncommunicablediseasesandtherapeuticopportunities
AT annarull mitochondrialdysfunctionabasicmechanismininflammationrelatednoncommunicablediseasesandtherapeuticopportunities
AT estherrodriguezgallego mitochondrialdysfunctionabasicmechanismininflammationrelatednoncommunicablediseasesandtherapeuticopportunities
AT martarieraborrull mitochondrialdysfunctionabasicmechanismininflammationrelatednoncommunicablediseasesandtherapeuticopportunities
AT fedralucianomateo mitochondrialdysfunctionabasicmechanismininflammationrelatednoncommunicablediseasesandtherapeuticopportunities
AT jordicamps mitochondrialdysfunctionabasicmechanismininflammationrelatednoncommunicablediseasesandtherapeuticopportunities
AT javieramenendez mitochondrialdysfunctionabasicmechanismininflammationrelatednoncommunicablediseasesandtherapeuticopportunities
AT jorgejoven mitochondrialdysfunctionabasicmechanismininflammationrelatednoncommunicablediseasesandtherapeuticopportunities