Genetic silencing of KCa3.1 inhibits atherosclerosis in ApoE null mice
Increased expression of KCa3.1 has been found in vascular smooth muscle cells (SMC), macrophages, and T cells in atherosclerotic lesions from humans and mice. Pharmacological inhibition of KCa3.1 in limiting atherosclerosis has been demonstrated in mice and pigs, however direct, loss-of-function, i....
Saved in:
| Main Authors: | P. Alam, D. L. Tharp, H. J. Bowles, L. A. Grisanti, H. Bui, S. B. Bender, D. K. Bowles |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
|
| Series: | Channels |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19336950.2025.2538864 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Administration of the KCa channel activator SKA-31 improves endothelial function in the aorta of atherosclerosis-prone mice
by: O. Daniel Vera, et al.
Published: (2025-02-01) -
Treatment of hypertension by increasing impaired endothelial TRPV4‐KCa2.3 interaction
by: Dongxu He, et al.
Published: (2017-09-01) -
Barium and psoriasis: a mini-review and hypothesis linking environmental exposures to ion channel modulation
by: Jordan Zeldin, et al.
Published: (2025-06-01) -
NaV1.5 or KCa2 channel blockade does not increase arrhythmia risk in hypokalemic rabbit hearts, unlike KV11.1 inhibition with dofetilide
by: Yannan Yan, et al.
Published: (2025-08-01) -
The simultaneous use of CRISPR/Cas9 to knock out the PI3Kca gene with radiation to enhance radiosensitivity and inhibit tumor growth in breast cancer
by: Amir Danyaei, et al.
Published: (2024-12-01)