Role of Transbronchial Lung Cryobiopsies in Diffuse Parenchymal Lung Diseases: Interest of a Sequential Approach
Background. Transbronchial lung cryobiopsies (TBLCs) are a promising diagnostic tool in the setting of diffuse parenchymal lung diseases (DPLDs). However, no comparison with surgical lung biopsy (SLB) in the same patient is available. Methods. The diagnostic yield and safety data of TBLCs, as well a...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Pulmonary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2017/6794343 |
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| author | Benjamin Bondue Thierry Pieters Patrick Alexander Paul De Vuyst Maria Ruiz Patino Delphine Hoton Myriam Remmelink Dimitri Leduc |
| author_facet | Benjamin Bondue Thierry Pieters Patrick Alexander Paul De Vuyst Maria Ruiz Patino Delphine Hoton Myriam Remmelink Dimitri Leduc |
| author_sort | Benjamin Bondue |
| collection | DOAJ |
| description | Background. Transbronchial lung cryobiopsies (TBLCs) are a promising diagnostic tool in the setting of diffuse parenchymal lung diseases (DPLDs). However, no comparison with surgical lung biopsy (SLB) in the same patient is available. Methods. The diagnostic yield and safety data of TBLCs, as well as the result of SLB performed after TBLCs, were analysed in a multicentric Belgian study. A SLB was performed after TBLCs in absence of a definite pathological diagnosis or if a NSIP pattern was observed without related condition identified following multidisciplinary discussion. Results. Between April 2015 and November 2016, 30 patients were included. Frequent complications included pneumothorax (20%) and bleeding (severe 7%, moderate 33%, and mild 53%). There was no mortality. The overall diagnostic yield was 80%. A SLB was performed in six patients (three without definite histological pattern and three with an NSIP). The surgical biopsy changed the pathological diagnosis into a UIP pattern in five patients and confirmed a NSIP pattern in one patient. Conclusion. TBLCs are useful in the diagnostic work-up of DPLDs avoiding a SLB in 80% of the patients. However, surgical biopsies, performed as a second step after TBLCs because of an indefinite diagnosis or a NSIP pattern, provide additional information supporting the interest of a sequential approach in these patients. |
| format | Article |
| id | doaj-art-1edf5687d70d42f398ee48dc5e67e8f3 |
| institution | Kabale University |
| issn | 2090-1836 2090-1844 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Medicine |
| spelling | doaj-art-1edf5687d70d42f398ee48dc5e67e8f32025-02-03T06:07:21ZengWileyPulmonary Medicine2090-18362090-18442017-01-01201710.1155/2017/67943436794343Role of Transbronchial Lung Cryobiopsies in Diffuse Parenchymal Lung Diseases: Interest of a Sequential ApproachBenjamin Bondue0Thierry Pieters1Patrick Alexander2Paul De Vuyst3Maria Ruiz Patino4Delphine Hoton5Myriam Remmelink6Dimitri Leduc7Department of Pneumology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, BelgiumDepartment of Pneumology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, BelgiumDepartment of Pneumology, AZ Glorieux, Ronse, BelgiumDepartment of Pneumology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, BelgiumDepartment of Thoracic Surgery, Hôpital Erasme, Université Libre de Bruxelles, Brussels, BelgiumDepartment of Pathology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, BelgiumDepartment of Pathology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, BelgiumDepartment of Pneumology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, BelgiumBackground. Transbronchial lung cryobiopsies (TBLCs) are a promising diagnostic tool in the setting of diffuse parenchymal lung diseases (DPLDs). However, no comparison with surgical lung biopsy (SLB) in the same patient is available. Methods. The diagnostic yield and safety data of TBLCs, as well as the result of SLB performed after TBLCs, were analysed in a multicentric Belgian study. A SLB was performed after TBLCs in absence of a definite pathological diagnosis or if a NSIP pattern was observed without related condition identified following multidisciplinary discussion. Results. Between April 2015 and November 2016, 30 patients were included. Frequent complications included pneumothorax (20%) and bleeding (severe 7%, moderate 33%, and mild 53%). There was no mortality. The overall diagnostic yield was 80%. A SLB was performed in six patients (three without definite histological pattern and three with an NSIP). The surgical biopsy changed the pathological diagnosis into a UIP pattern in five patients and confirmed a NSIP pattern in one patient. Conclusion. TBLCs are useful in the diagnostic work-up of DPLDs avoiding a SLB in 80% of the patients. However, surgical biopsies, performed as a second step after TBLCs because of an indefinite diagnosis or a NSIP pattern, provide additional information supporting the interest of a sequential approach in these patients.http://dx.doi.org/10.1155/2017/6794343 |
| spellingShingle | Benjamin Bondue Thierry Pieters Patrick Alexander Paul De Vuyst Maria Ruiz Patino Delphine Hoton Myriam Remmelink Dimitri Leduc Role of Transbronchial Lung Cryobiopsies in Diffuse Parenchymal Lung Diseases: Interest of a Sequential Approach Pulmonary Medicine |
| title | Role of Transbronchial Lung Cryobiopsies in Diffuse Parenchymal Lung Diseases: Interest of a Sequential Approach |
| title_full | Role of Transbronchial Lung Cryobiopsies in Diffuse Parenchymal Lung Diseases: Interest of a Sequential Approach |
| title_fullStr | Role of Transbronchial Lung Cryobiopsies in Diffuse Parenchymal Lung Diseases: Interest of a Sequential Approach |
| title_full_unstemmed | Role of Transbronchial Lung Cryobiopsies in Diffuse Parenchymal Lung Diseases: Interest of a Sequential Approach |
| title_short | Role of Transbronchial Lung Cryobiopsies in Diffuse Parenchymal Lung Diseases: Interest of a Sequential Approach |
| title_sort | role of transbronchial lung cryobiopsies in diffuse parenchymal lung diseases interest of a sequential approach |
| url | http://dx.doi.org/10.1155/2017/6794343 |
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