Changes in Mobility of the Golden Hamster with Induction of an IL-1-Induced Arthritis
Many studies in animals have examined biochemical, immune and histological changes during arthritis; however, the study of the effects of arthritis on mobility has been largely neglected. Interleukin-1, administered by the intraarticular route into hamster knee joints, resulted in inhibition of spon...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1994-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S096293519400027X |
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| Summary: | Many studies in animals have examined biochemical, immune and
histological changes during arthritis; however, the study of the
effects of arthritis on mobility has been largely neglected.
Interleukin-1, administered by the intraarticular route into hamster
knee joints, resulted in inhibition of spontaneous wheel running
activity; however, the effect was transient, lasting only through
the evening following IL-1 administration. A further injection of
IL-1 2 days later showed still greater inhibition of running. The
effect again did not extend beyond the first evening after
injection. IL-1α and IL-1β showed equivalent effects on
mobility, and no evidence was seen for cooperative interaction
between them. A 50% inhibition of running occurred at a dose
of approximately 10 ng/knee of IL-1α. The effect appeared
not to be systemic since intraperitoneal injection required
microgram amounts of IL-1 for an equivalent inhibition. At the time
mobility had been restored to normal, histological examination
showed the continued presence of inflammatory cells, soft tissue
swelling and cartilage proteoglycan loss. These results suggest a
lack of correlation between inhibition of mobility and
histopathological changes in cartilage and soft tissue. |
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| ISSN: | 0962-9351 1466-1861 |