Hepatic Damage Induced By Fructose And Aspartame In Carbonated Drinks: Morphological And Histological Analysis In Adult Male Albino Rats
Objective: The study aims to analyze the changes produced by fructose and aspartame in regular and zero-calorie carbonated drinks respectively on the morphology and histology of the liver of adult male albino rats. Methods: Regular and zero-calorie carbonated drinks in a dosage of 10 ml/kg body w...
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Rawalpindi Medical University
2024-12-01
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| Series: | Journal of Rawalpindi Medical College |
| Online Access: | https://www.journalrmc.com/index.php/JRMC/article/view/2541 |
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| author | Faiza Shafqat Muhammad Suhail Ayesha Ali Hafsa Nazeer Sadia Iqbal Saqib Mansoor |
| author_facet | Faiza Shafqat Muhammad Suhail Ayesha Ali Hafsa Nazeer Sadia Iqbal Saqib Mansoor |
| author_sort | Faiza Shafqat |
| collection | DOAJ |
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Objective: The study aims to analyze the changes produced by fructose and aspartame in regular and zero-calorie carbonated drinks respectively on the morphology and histology of the liver of adult male albino rats.
Methods: Regular and zero-calorie carbonated drinks in a dosage of 10 ml/kg body weight were administered by oral gavage daily to experimental groups B and C (10 rats in each group) respectively for 21 consecutive days. The weight of animals was noted at the start and end of the experiment. The liver was excised in each animal, weighed, fixed in formalin, and stained with Hematoxylin and Eosin and histological changes such as detachment of capsule, congestion and inflammation of portal triad were observed for comparison between the experimental groups.
Results: Results were recorded and analyzed in the form of photomicrographs. Observations showed a rise in the weight of animals and liver of experimental groups B and C compared to control group A. The shape of the liver was normal. Histological changes including detachment of capsule, inflammation of portal triad, congestion of hepatic sinusoids and portal triad, were observed in both the experimental groups indicating damage to hepatic tissue.
Conclusion: Therefore, it is concluded that consumption of regular and zero-calorie carbonated drinks should be restricted to avoid their harmful effects on the liver leading to hepatotoxicity.
Keywords: Fructose, Aspartame, regular and zero calorie carbonated drinks, liver
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| format | Article |
| id | doaj-art-1ed1ba9fc63b43b4a6d280710ac23cba |
| institution | Kabale University |
| issn | 1683-3562 1683-3570 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Rawalpindi Medical University |
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| series | Journal of Rawalpindi Medical College |
| spelling | doaj-art-1ed1ba9fc63b43b4a6d280710ac23cba2025-02-06T08:34:04ZengRawalpindi Medical UniversityJournal of Rawalpindi Medical College1683-35621683-35702024-12-0128410.37939/jrmc.v28i4.2541Hepatic Damage Induced By Fructose And Aspartame In Carbonated Drinks: Morphological And Histological Analysis In Adult Male Albino RatsFaiza Shafqat0Muhammad Suhail1Ayesha Ali2Hafsa NazeerSadia IqbalSaqib Mansoor3Islamabad medical and dental collegeAmna Inayat Medical College SheikhupuraIslamabad medical and dental collegeNiazi Medical and Dental College Objective: The study aims to analyze the changes produced by fructose and aspartame in regular and zero-calorie carbonated drinks respectively on the morphology and histology of the liver of adult male albino rats. Methods: Regular and zero-calorie carbonated drinks in a dosage of 10 ml/kg body weight were administered by oral gavage daily to experimental groups B and C (10 rats in each group) respectively for 21 consecutive days. The weight of animals was noted at the start and end of the experiment. The liver was excised in each animal, weighed, fixed in formalin, and stained with Hematoxylin and Eosin and histological changes such as detachment of capsule, congestion and inflammation of portal triad were observed for comparison between the experimental groups. Results: Results were recorded and analyzed in the form of photomicrographs. Observations showed a rise in the weight of animals and liver of experimental groups B and C compared to control group A. The shape of the liver was normal. Histological changes including detachment of capsule, inflammation of portal triad, congestion of hepatic sinusoids and portal triad, were observed in both the experimental groups indicating damage to hepatic tissue. Conclusion: Therefore, it is concluded that consumption of regular and zero-calorie carbonated drinks should be restricted to avoid their harmful effects on the liver leading to hepatotoxicity. Keywords: Fructose, Aspartame, regular and zero calorie carbonated drinks, liver https://www.journalrmc.com/index.php/JRMC/article/view/2541 |
| spellingShingle | Faiza Shafqat Muhammad Suhail Ayesha Ali Hafsa Nazeer Sadia Iqbal Saqib Mansoor Hepatic Damage Induced By Fructose And Aspartame In Carbonated Drinks: Morphological And Histological Analysis In Adult Male Albino Rats Journal of Rawalpindi Medical College |
| title | Hepatic Damage Induced By Fructose And Aspartame In Carbonated Drinks: Morphological And Histological Analysis In Adult Male Albino Rats |
| title_full | Hepatic Damage Induced By Fructose And Aspartame In Carbonated Drinks: Morphological And Histological Analysis In Adult Male Albino Rats |
| title_fullStr | Hepatic Damage Induced By Fructose And Aspartame In Carbonated Drinks: Morphological And Histological Analysis In Adult Male Albino Rats |
| title_full_unstemmed | Hepatic Damage Induced By Fructose And Aspartame In Carbonated Drinks: Morphological And Histological Analysis In Adult Male Albino Rats |
| title_short | Hepatic Damage Induced By Fructose And Aspartame In Carbonated Drinks: Morphological And Histological Analysis In Adult Male Albino Rats |
| title_sort | hepatic damage induced by fructose and aspartame in carbonated drinks morphological and histological analysis in adult male albino rats |
| url | https://www.journalrmc.com/index.php/JRMC/article/view/2541 |
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