PKM2 Promotes Breast Cancer Progression by Regulating Epithelial Mesenchymal Transition
Breast cancer is the leading cause of females characterized by high invasive potential. It is necessary to explore the underlying mechanism of breast cancer metastases and to find specific therapeutic targets. PKM2 is considered a new biomarker of cancer with upregulated expression in tumor tissue....
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/2020/8396023 |
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| _version_ | 1832563340519407616 |
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| author | Hui Xiao Longxiao Zhang Yuan Chen Chengjun Zhou Xiao Wang Dehai Wang Zhenzhong Liu |
| author_facet | Hui Xiao Longxiao Zhang Yuan Chen Chengjun Zhou Xiao Wang Dehai Wang Zhenzhong Liu |
| author_sort | Hui Xiao |
| collection | DOAJ |
| description | Breast cancer is the leading cause of females characterized by high invasive potential. It is necessary to explore the underlying mechanism of breast cancer metastases and to find specific therapeutic targets. PKM2 is considered a new biomarker of cancer with upregulated expression in tumor tissue. PKM2 participates in the cancer-specific Warburg effect to regulate fast glucose intake consumption. Besides, PKM2 also contributes to cancer progression, especially tumor metastasis. In this study, we showed that PKM2 is upregulated in breast cancer tissues and the upregulating of PKM2 in breast cancer correlates with poor prognosis. PKM2 can regulate tumor progression by promoting tumor cell viability and mobility. Furthermore, overexpression of PKM2 can promote EMT to encourage tumor metastasis. These findings indicate PKM2 is a potentially useful diagnostic biomarker and therapeutic target in breast cancer. |
| format | Article |
| id | doaj-art-1ed028f8610844f5a113205a495cff00 |
| institution | Kabale University |
| issn | 2210-7177 2210-7185 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-1ed028f8610844f5a113205a495cff002025-02-03T01:20:20ZengWileyAnalytical Cellular Pathology2210-71772210-71852020-01-01202010.1155/2020/83960238396023PKM2 Promotes Breast Cancer Progression by Regulating Epithelial Mesenchymal TransitionHui Xiao0Longxiao Zhang1Yuan Chen2Chengjun Zhou3Xiao Wang4Dehai Wang5Zhenzhong Liu6The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250033, ChinaThe Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, ChinaThe Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250033, ChinaThe Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250033, ChinaThe Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250033, ChinaThe Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250033, ChinaThe Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250033, ChinaBreast cancer is the leading cause of females characterized by high invasive potential. It is necessary to explore the underlying mechanism of breast cancer metastases and to find specific therapeutic targets. PKM2 is considered a new biomarker of cancer with upregulated expression in tumor tissue. PKM2 participates in the cancer-specific Warburg effect to regulate fast glucose intake consumption. Besides, PKM2 also contributes to cancer progression, especially tumor metastasis. In this study, we showed that PKM2 is upregulated in breast cancer tissues and the upregulating of PKM2 in breast cancer correlates with poor prognosis. PKM2 can regulate tumor progression by promoting tumor cell viability and mobility. Furthermore, overexpression of PKM2 can promote EMT to encourage tumor metastasis. These findings indicate PKM2 is a potentially useful diagnostic biomarker and therapeutic target in breast cancer.http://dx.doi.org/10.1155/2020/8396023 |
| spellingShingle | Hui Xiao Longxiao Zhang Yuan Chen Chengjun Zhou Xiao Wang Dehai Wang Zhenzhong Liu PKM2 Promotes Breast Cancer Progression by Regulating Epithelial Mesenchymal Transition Analytical Cellular Pathology |
| title | PKM2 Promotes Breast Cancer Progression by Regulating Epithelial Mesenchymal Transition |
| title_full | PKM2 Promotes Breast Cancer Progression by Regulating Epithelial Mesenchymal Transition |
| title_fullStr | PKM2 Promotes Breast Cancer Progression by Regulating Epithelial Mesenchymal Transition |
| title_full_unstemmed | PKM2 Promotes Breast Cancer Progression by Regulating Epithelial Mesenchymal Transition |
| title_short | PKM2 Promotes Breast Cancer Progression by Regulating Epithelial Mesenchymal Transition |
| title_sort | pkm2 promotes breast cancer progression by regulating epithelial mesenchymal transition |
| url | http://dx.doi.org/10.1155/2020/8396023 |
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