A highly sensitive tapered fiber biosensor modified by PDMS combustion product and graphene oxide for MUC1 detection
It is a critical challenge to develop reliable, stable, and sensitive biosensors for specific detection of mucin 1 (MUC1). In this paper, a label-free biosensor based on polydimethylsiloxane (PDMS) combustion product and graphene oxide (GO) functionalized tapered fiber (PGTF) was proposed and demons...
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Elsevier
2025-06-01
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| Series: | Sensors and Actuators Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666053925000074 |
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| author | Bo Wang Shanren Liu Mengmeng Gao Yuanjun Li Heer Yang Cai Sun Qi Guo Yongsen Yu |
| author_facet | Bo Wang Shanren Liu Mengmeng Gao Yuanjun Li Heer Yang Cai Sun Qi Guo Yongsen Yu |
| author_sort | Bo Wang |
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| description | It is a critical challenge to develop reliable, stable, and sensitive biosensors for specific detection of mucin 1 (MUC1). In this paper, a label-free biosensor based on polydimethylsiloxane (PDMS) combustion product and graphene oxide (GO) functionalized tapered fiber (PGTF) was proposed and demonstrated for high sensitivity MUC1 detection. The PDMS combustion product is mainly composed of SiO2, which can be firmly bonded to the surface of the fiber, effectively increasing the specific surface area of the fiber. At the same time, the combination of the PDMS combustion product and the fiber cladding material will generate defects in the cladding, resulting in easier leakage of light inside the fiber core. Therefore, a strong evanescent field and interference effect can be obtained without drawing the tapered fiber waist very thin, which contributes to improving the sensitivity of fiber biosensor. In addition, GO has good biological affinity, a large specific surface area, and abundant functional groups, which can provide more binding sites for the attachment of biomolecule. The detection limit of the PGTF is 0.11 pM when the diameter of the fiber taper is 50 μm and modified with five layers of PDMS combustion product. Experimentally demonstrated sensor specificity and reproducibility, indicating that the sensor has a practical value for real applications. The PGTF has great potential as a simple, sensitive, and label-free assay in the field of cancer marker detection. |
| format | Article |
| id | doaj-art-1ece9ddcac4a4443bcdeff0f126dbc80 |
| institution | Kabale University |
| issn | 2666-0539 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
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| series | Sensors and Actuators Reports |
| spelling | doaj-art-1ece9ddcac4a4443bcdeff0f126dbc802025-01-26T05:04:54ZengElsevierSensors and Actuators Reports2666-05392025-06-019100287A highly sensitive tapered fiber biosensor modified by PDMS combustion product and graphene oxide for MUC1 detectionBo Wang0Shanren Liu1Mengmeng Gao2Yuanjun Li3Heer Yang4Cai Sun5Qi Guo6Yongsen Yu7State Key Laboratory of Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, ChinaState Key Laboratory of Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, ChinaState Key Laboratory of Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, ChinaState Key Laboratory of Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, ChinaState Key Laboratory of Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, ChinaState Key Laboratory of Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, ChinaCorresponding authors.; State Key Laboratory of Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, ChinaCorresponding authors.; State Key Laboratory of Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, ChinaIt is a critical challenge to develop reliable, stable, and sensitive biosensors for specific detection of mucin 1 (MUC1). In this paper, a label-free biosensor based on polydimethylsiloxane (PDMS) combustion product and graphene oxide (GO) functionalized tapered fiber (PGTF) was proposed and demonstrated for high sensitivity MUC1 detection. The PDMS combustion product is mainly composed of SiO2, which can be firmly bonded to the surface of the fiber, effectively increasing the specific surface area of the fiber. At the same time, the combination of the PDMS combustion product and the fiber cladding material will generate defects in the cladding, resulting in easier leakage of light inside the fiber core. Therefore, a strong evanescent field and interference effect can be obtained without drawing the tapered fiber waist very thin, which contributes to improving the sensitivity of fiber biosensor. In addition, GO has good biological affinity, a large specific surface area, and abundant functional groups, which can provide more binding sites for the attachment of biomolecule. The detection limit of the PGTF is 0.11 pM when the diameter of the fiber taper is 50 μm and modified with five layers of PDMS combustion product. Experimentally demonstrated sensor specificity and reproducibility, indicating that the sensor has a practical value for real applications. The PGTF has great potential as a simple, sensitive, and label-free assay in the field of cancer marker detection.http://www.sciencedirect.com/science/article/pii/S2666053925000074Label-free biosensorTapered fiber biosensorPDMS combustion productGraphene oxideMUC1 detection |
| spellingShingle | Bo Wang Shanren Liu Mengmeng Gao Yuanjun Li Heer Yang Cai Sun Qi Guo Yongsen Yu A highly sensitive tapered fiber biosensor modified by PDMS combustion product and graphene oxide for MUC1 detection Sensors and Actuators Reports Label-free biosensor Tapered fiber biosensor PDMS combustion product Graphene oxide MUC1 detection |
| title | A highly sensitive tapered fiber biosensor modified by PDMS combustion product and graphene oxide for MUC1 detection |
| title_full | A highly sensitive tapered fiber biosensor modified by PDMS combustion product and graphene oxide for MUC1 detection |
| title_fullStr | A highly sensitive tapered fiber biosensor modified by PDMS combustion product and graphene oxide for MUC1 detection |
| title_full_unstemmed | A highly sensitive tapered fiber biosensor modified by PDMS combustion product and graphene oxide for MUC1 detection |
| title_short | A highly sensitive tapered fiber biosensor modified by PDMS combustion product and graphene oxide for MUC1 detection |
| title_sort | highly sensitive tapered fiber biosensor modified by pdms combustion product and graphene oxide for muc1 detection |
| topic | Label-free biosensor Tapered fiber biosensor PDMS combustion product Graphene oxide MUC1 detection |
| url | http://www.sciencedirect.com/science/article/pii/S2666053925000074 |
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