A Comparative Evaluation of the Mechanical Properties of Two Calcium Phosphate/Collagen Composite Materials and Their Osteogenic Effects on Adipose-Derived Stem Cells
Adipose-derived stem cells (ADSCs) are ideal seed cells for use in bone tissue engineering and they have many advantages over other stem cells. In this study, two kinds of calcium phosphate/collagen composite scaffolds were prepared and their effects on the proliferation and osteogenic differentiati...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/6409546 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832555409739612160 |
|---|---|
| author | Qing Li Tong Wang Gui-feng Zhang Xin Yu Jing Zhang Gang Zhou Zhi-hui Tang |
| author_facet | Qing Li Tong Wang Gui-feng Zhang Xin Yu Jing Zhang Gang Zhou Zhi-hui Tang |
| author_sort | Qing Li |
| collection | DOAJ |
| description | Adipose-derived stem cells (ADSCs) are ideal seed cells for use in bone tissue engineering and they have many advantages over other stem cells. In this study, two kinds of calcium phosphate/collagen composite scaffolds were prepared and their effects on the proliferation and osteogenic differentiation of ADSCs were investigated. The hydroxyapatite/β-tricalcium phosphate (HA/β-TCP) composite scaffolds (HTPSs), which have an additional β-tricalcium phosphate, resulted in better proliferation of ADSCs and showed osteogenesis-promoting effects. Therefore, such composite scaffolds, in combination with ADSCs or on their own, would be promising for use in bone regeneration and potential clinical therapy for bone defects. |
| format | Article |
| id | doaj-art-1eccda9d877b422395038f64e0a158e9 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-1eccda9d877b422395038f64e0a158e92025-02-03T05:48:16ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/64095466409546A Comparative Evaluation of the Mechanical Properties of Two Calcium Phosphate/Collagen Composite Materials and Their Osteogenic Effects on Adipose-Derived Stem CellsQing Li0Tong Wang1Gui-feng Zhang2Xin Yu3Jing Zhang4Gang Zhou5Zhi-hui Tang6National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing 100081, China2nd Dental Center, Peking University School and Hospital of Stomatology, Beijing 100101, ChinaInstitute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, ChinaKey Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, ChinaKey Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, ChinaKey Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, ChinaNational Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing 100081, ChinaAdipose-derived stem cells (ADSCs) are ideal seed cells for use in bone tissue engineering and they have many advantages over other stem cells. In this study, two kinds of calcium phosphate/collagen composite scaffolds were prepared and their effects on the proliferation and osteogenic differentiation of ADSCs were investigated. The hydroxyapatite/β-tricalcium phosphate (HA/β-TCP) composite scaffolds (HTPSs), which have an additional β-tricalcium phosphate, resulted in better proliferation of ADSCs and showed osteogenesis-promoting effects. Therefore, such composite scaffolds, in combination with ADSCs or on their own, would be promising for use in bone regeneration and potential clinical therapy for bone defects.http://dx.doi.org/10.1155/2016/6409546 |
| spellingShingle | Qing Li Tong Wang Gui-feng Zhang Xin Yu Jing Zhang Gang Zhou Zhi-hui Tang A Comparative Evaluation of the Mechanical Properties of Two Calcium Phosphate/Collagen Composite Materials and Their Osteogenic Effects on Adipose-Derived Stem Cells Stem Cells International |
| title | A Comparative Evaluation of the Mechanical Properties of Two Calcium Phosphate/Collagen Composite Materials and Their Osteogenic Effects on Adipose-Derived Stem Cells |
| title_full | A Comparative Evaluation of the Mechanical Properties of Two Calcium Phosphate/Collagen Composite Materials and Their Osteogenic Effects on Adipose-Derived Stem Cells |
| title_fullStr | A Comparative Evaluation of the Mechanical Properties of Two Calcium Phosphate/Collagen Composite Materials and Their Osteogenic Effects on Adipose-Derived Stem Cells |
| title_full_unstemmed | A Comparative Evaluation of the Mechanical Properties of Two Calcium Phosphate/Collagen Composite Materials and Their Osteogenic Effects on Adipose-Derived Stem Cells |
| title_short | A Comparative Evaluation of the Mechanical Properties of Two Calcium Phosphate/Collagen Composite Materials and Their Osteogenic Effects on Adipose-Derived Stem Cells |
| title_sort | comparative evaluation of the mechanical properties of two calcium phosphate collagen composite materials and their osteogenic effects on adipose derived stem cells |
| url | http://dx.doi.org/10.1155/2016/6409546 |
| work_keys_str_mv | AT qingli acomparativeevaluationofthemechanicalpropertiesoftwocalciumphosphatecollagencompositematerialsandtheirosteogeniceffectsonadiposederivedstemcells AT tongwang acomparativeevaluationofthemechanicalpropertiesoftwocalciumphosphatecollagencompositematerialsandtheirosteogeniceffectsonadiposederivedstemcells AT guifengzhang acomparativeevaluationofthemechanicalpropertiesoftwocalciumphosphatecollagencompositematerialsandtheirosteogeniceffectsonadiposederivedstemcells AT xinyu acomparativeevaluationofthemechanicalpropertiesoftwocalciumphosphatecollagencompositematerialsandtheirosteogeniceffectsonadiposederivedstemcells AT jingzhang acomparativeevaluationofthemechanicalpropertiesoftwocalciumphosphatecollagencompositematerialsandtheirosteogeniceffectsonadiposederivedstemcells AT gangzhou acomparativeevaluationofthemechanicalpropertiesoftwocalciumphosphatecollagencompositematerialsandtheirosteogeniceffectsonadiposederivedstemcells AT zhihuitang acomparativeevaluationofthemechanicalpropertiesoftwocalciumphosphatecollagencompositematerialsandtheirosteogeniceffectsonadiposederivedstemcells AT qingli comparativeevaluationofthemechanicalpropertiesoftwocalciumphosphatecollagencompositematerialsandtheirosteogeniceffectsonadiposederivedstemcells AT tongwang comparativeevaluationofthemechanicalpropertiesoftwocalciumphosphatecollagencompositematerialsandtheirosteogeniceffectsonadiposederivedstemcells AT guifengzhang comparativeevaluationofthemechanicalpropertiesoftwocalciumphosphatecollagencompositematerialsandtheirosteogeniceffectsonadiposederivedstemcells AT xinyu comparativeevaluationofthemechanicalpropertiesoftwocalciumphosphatecollagencompositematerialsandtheirosteogeniceffectsonadiposederivedstemcells AT jingzhang comparativeevaluationofthemechanicalpropertiesoftwocalciumphosphatecollagencompositematerialsandtheirosteogeniceffectsonadiposederivedstemcells AT gangzhou comparativeevaluationofthemechanicalpropertiesoftwocalciumphosphatecollagencompositematerialsandtheirosteogeniceffectsonadiposederivedstemcells AT zhihuitang comparativeevaluationofthemechanicalpropertiesoftwocalciumphosphatecollagencompositematerialsandtheirosteogeniceffectsonadiposederivedstemcells |