Bowel Perforation in Premature Infants with Necrotizing Enterocolitis: Risk Factors and Outcomes
We aim to determine risk factors and clinical outcomes for bowel perforation in premature infants with NEC. We analyzed clinical data of 57 cases of premature infants with NEC at our NICU between January 2010 and December 2012. Based on the presence of bowel perforation, we divided these infants int...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/6134187 |
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| author | Lingling Yu Jianmei Tian Xingli Zhao Ping Cheng Xiaoqian Chen Yun Yu Xiaochun Ding Xueping Zhu Zhihui Xiao |
| author_facet | Lingling Yu Jianmei Tian Xingli Zhao Ping Cheng Xiaoqian Chen Yun Yu Xiaochun Ding Xueping Zhu Zhihui Xiao |
| author_sort | Lingling Yu |
| collection | DOAJ |
| description | We aim to determine risk factors and clinical outcomes for bowel perforation in premature infants with NEC. We analyzed clinical data of 57 cases of premature infants with NEC at our NICU between January 2010 and December 2012. Based on the presence of bowel perforation, we divided these infants into two groups: perforated NEC group (n=10) and nonperforated NEC group (n=47). We compared general information, clinical characteristics, and laboratory findings between groups. The perforated NEC group, compared to the nonperforated NEC group, had significantly lesser gestational age, lower birth weight, higher prevalence of apnea, mechanical ventilation, sepsis and shock, lower blood pH, higher levels of blood glucose, abnormal WBC count and thrombocytopenia, and elevated CRP (all P<0.05). Moreover, the perforated NEC group had significantly longer durations of fasting and TPN usage, higher incidences of EUGR and cholestasis, longer duration of antibiotics, higher frequency of advanced antibiotics use, and poorer prognosis than the nonperforated NEC group (all P<0.05). Bowel perforation in premature infants with NEC was associated with multiple risk factors. Early identification of some of these risk factors in premature infants with NEC may help implement early intervention to reduce the incidence of bowel perforation and thereby improve the prognosis. |
| format | Article |
| id | doaj-art-1eaf96a707aa459b9e4320216ba35309 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-1eaf96a707aa459b9e4320216ba353092025-02-03T07:26:01ZengWileyGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/61341876134187Bowel Perforation in Premature Infants with Necrotizing Enterocolitis: Risk Factors and OutcomesLingling Yu0Jianmei Tian1Xingli Zhao2Ping Cheng3Xiaoqian Chen4Yun Yu5Xiaochun Ding6Xueping Zhu7Zhihui Xiao8Department of Neonatology, Children’s Hospital of Soochow University, Suzhou 215003, ChinaDepartment of Infectious Disease, Children’s Hospital of Soochow University, Suzhou 215003, ChinaDepartment of Neonatology, Children’s Hospital of Soochow University, Suzhou 215003, ChinaDepartment of Neonatology, Children’s Hospital of Soochow University, Suzhou 215003, ChinaDepartment of Neonatology, Children’s Hospital of Soochow University, Suzhou 215003, ChinaDepartment of Neonatology, Children’s Hospital of Soochow University, Suzhou 215003, ChinaDepartment of Neonatology, Children’s Hospital of Soochow University, Suzhou 215003, ChinaDepartment of Neonatology, Children’s Hospital of Soochow University, Suzhou 215003, ChinaDepartment of Neonatology, Children’s Hospital of Soochow University, Suzhou 215003, ChinaWe aim to determine risk factors and clinical outcomes for bowel perforation in premature infants with NEC. We analyzed clinical data of 57 cases of premature infants with NEC at our NICU between January 2010 and December 2012. Based on the presence of bowel perforation, we divided these infants into two groups: perforated NEC group (n=10) and nonperforated NEC group (n=47). We compared general information, clinical characteristics, and laboratory findings between groups. The perforated NEC group, compared to the nonperforated NEC group, had significantly lesser gestational age, lower birth weight, higher prevalence of apnea, mechanical ventilation, sepsis and shock, lower blood pH, higher levels of blood glucose, abnormal WBC count and thrombocytopenia, and elevated CRP (all P<0.05). Moreover, the perforated NEC group had significantly longer durations of fasting and TPN usage, higher incidences of EUGR and cholestasis, longer duration of antibiotics, higher frequency of advanced antibiotics use, and poorer prognosis than the nonperforated NEC group (all P<0.05). Bowel perforation in premature infants with NEC was associated with multiple risk factors. Early identification of some of these risk factors in premature infants with NEC may help implement early intervention to reduce the incidence of bowel perforation and thereby improve the prognosis.http://dx.doi.org/10.1155/2016/6134187 |
| spellingShingle | Lingling Yu Jianmei Tian Xingli Zhao Ping Cheng Xiaoqian Chen Yun Yu Xiaochun Ding Xueping Zhu Zhihui Xiao Bowel Perforation in Premature Infants with Necrotizing Enterocolitis: Risk Factors and Outcomes Gastroenterology Research and Practice |
| title | Bowel Perforation in Premature Infants with Necrotizing Enterocolitis: Risk Factors and Outcomes |
| title_full | Bowel Perforation in Premature Infants with Necrotizing Enterocolitis: Risk Factors and Outcomes |
| title_fullStr | Bowel Perforation in Premature Infants with Necrotizing Enterocolitis: Risk Factors and Outcomes |
| title_full_unstemmed | Bowel Perforation in Premature Infants with Necrotizing Enterocolitis: Risk Factors and Outcomes |
| title_short | Bowel Perforation in Premature Infants with Necrotizing Enterocolitis: Risk Factors and Outcomes |
| title_sort | bowel perforation in premature infants with necrotizing enterocolitis risk factors and outcomes |
| url | http://dx.doi.org/10.1155/2016/6134187 |
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