Epigenomic preconditioning of peripheral monocytes determines their transcriptional response to the tumor microenvironment

Epigenomic preconditioning of peripheral monocytes determines their transcriptional response to the tumor microenvironment

Abstract Background Monocytes are recruited to tumors and undergo transcriptional reprogramming resulting in tumor-promoting functions. Epigenomic features, such as post-translational modification of histones and chromatin accessibility, are key determinants of transcription factor binding and there...

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Main Authors: Máté Kiss, Laszlo Halasz, Eva Hadadi, Wilhelm K. Berger, Petros Tzerpos, Szilard Poliska, Daliya Kancheva, Aurélie Gabriel, Romina Mora Barthelmess, Ayla Debraekeleer, Jan Brughmans, Yvon Elkrim, Liesbet Martens, Yvan Saeys, Bence Daniel, Zsolt Czimmerer, Damya Laoui, Laszlo Nagy, Jo A. Van Ginderachter
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Genome Medicine
Subjects:
Cancer
Monocyte
Epigenome
Transcriptome
Enhancer
Histone
Online Access:https://doi.org/10.1186/s13073-025-01511-y
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