Destabilization signs in behavioral and somatovegetative parameters of rats selected for catatonia
The article presents data on destabilization signs in response to selection for catatonia at an organismal level. Experiments were conducted with the unique GC (genetic catatonia) rat strain selected for long passive-defensive freezing. The goal of this study was to detect destabilization signs in t...
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| Format: | Article |
| Language: | English |
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Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders
2016-03-01
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| Series: | Вавиловский журнал генетики и селекции |
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| Online Access: | https://vavilov.elpub.ru/jour/article/view/520 |
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| author | T. A. Alekhina N. A. Palchikova R. V. Kozhemyakina O. I. Prokudina |
| author_facet | T. A. Alekhina N. A. Palchikova R. V. Kozhemyakina O. I. Prokudina |
| author_sort | T. A. Alekhina |
| collection | DOAJ |
| description | The article presents data on destabilization signs in response to selection for catatonia at an organismal level. Experiments were conducted with the unique GC (genetic catatonia) rat strain selected for long passive-defensive freezing. The goal of this study was to detect destabilization signs in the behavioral and somatovegetative parameters of GC rats emerging in response to selection. The destabilization manifested itself as changes in rat attitudes towards humans, as became apparent from the glove test. Altered hormone levels in GC rats were detected: corticosterone concentrations were reduced in feces and increased during handling. The metabolic system showed a decrease in energy stored accompanying the fast (glucose level) and slow (triglyceride level) responses. However, the strains did not differ in the concentration of insulin, which affects glucose transport through the cell membrane. Nor did we find differences between Wistar and GC rats in cholesterol level. This lipid is important for both energy and constructive metabolism. A side effect of selection for catatonia was the worse pelage status in GC rats. The overall physical condition of catatonic rats involved reduced body weight in both neonates and adults. All these changes point to the modification of behavioral and somatovegetative patterns and intensification of the passive-defensive component of selection in GC rats. |
| format | Article |
| id | doaj-art-1e977d568d954f35b95e69040eae2fab |
| institution | Kabale University |
| issn | 2500-3259 |
| language | English |
| publishDate | 2016-03-01 |
| publisher | Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders |
| record_format | Article |
| series | Вавиловский журнал генетики и селекции |
| spelling | doaj-art-1e977d568d954f35b95e69040eae2fab2025-02-01T09:58:02ZengSiberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and BreedersВавиловский журнал генетики и селекции2500-32592016-03-01201283310.18699/VJ16.103441Destabilization signs in behavioral and somatovegetative parameters of rats selected for catatoniaT. A. Alekhina0N. A. Palchikova1R. V. Kozhemyakina2O. I. Prokudina3Institute of Cytology and Genetics SB RAS, Novosibirsk, RussiaFederal State Budgetary Scientific Institution «Research Institute of Experimental and Clinical Medicine», Novosibirsk, RussiaInstitute of Cytology and Genetics SB RAS, Novosibirsk, RussiaInstitute of Cytology and Genetics SB RAS, Novosibirsk, RussiaThe article presents data on destabilization signs in response to selection for catatonia at an organismal level. Experiments were conducted with the unique GC (genetic catatonia) rat strain selected for long passive-defensive freezing. The goal of this study was to detect destabilization signs in the behavioral and somatovegetative parameters of GC rats emerging in response to selection. The destabilization manifested itself as changes in rat attitudes towards humans, as became apparent from the glove test. Altered hormone levels in GC rats were detected: corticosterone concentrations were reduced in feces and increased during handling. The metabolic system showed a decrease in energy stored accompanying the fast (glucose level) and slow (triglyceride level) responses. However, the strains did not differ in the concentration of insulin, which affects glucose transport through the cell membrane. Nor did we find differences between Wistar and GC rats in cholesterol level. This lipid is important for both energy and constructive metabolism. A side effect of selection for catatonia was the worse pelage status in GC rats. The overall physical condition of catatonic rats involved reduced body weight in both neonates and adults. All these changes point to the modification of behavioral and somatovegetative patterns and intensification of the passive-defensive component of selection in GC rats.https://vavilov.elpub.ru/jour/article/view/520selection modelcatatoniahormoneshairbody weightglove testimmune-enzyme analysislight microscopy |
| spellingShingle | T. A. Alekhina N. A. Palchikova R. V. Kozhemyakina O. I. Prokudina Destabilization signs in behavioral and somatovegetative parameters of rats selected for catatonia Вавиловский журнал генетики и селекции selection model catatonia hormones hair body weight glove test immune-enzyme analysis light microscopy |
| title | Destabilization signs in behavioral and somatovegetative parameters of rats selected for catatonia |
| title_full | Destabilization signs in behavioral and somatovegetative parameters of rats selected for catatonia |
| title_fullStr | Destabilization signs in behavioral and somatovegetative parameters of rats selected for catatonia |
| title_full_unstemmed | Destabilization signs in behavioral and somatovegetative parameters of rats selected for catatonia |
| title_short | Destabilization signs in behavioral and somatovegetative parameters of rats selected for catatonia |
| title_sort | destabilization signs in behavioral and somatovegetative parameters of rats selected for catatonia |
| topic | selection model catatonia hormones hair body weight glove test immune-enzyme analysis light microscopy |
| url | https://vavilov.elpub.ru/jour/article/view/520 |
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