The efficacy and safety of peroperative statin treatment during coronary artery bypass grafting
The aim – to evaluate the efficacy and safety of perioperative statins treatment during coronary artery bypass graft surgery (CABG). Materials and methods. The data from clinical and instrumental examination of 155 patients with stable coronary heart disease (CHD) consecutively selected for CABG...
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| Format: | Article |
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TOV Chetverta Khvylia
2018-03-01
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| Series: | Кардіохірургія та інтервенційна кардіологія |
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| Online Access: | http://csic.com.ua/images/pdf/2018/1-2018/efficacy-safety-of-peroperative-statin-treatment-during-coronary-artery-bypass-grafting.pdf |
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| author | I.V. Shklianka O.J. Zharinov К.O. Mikhaliev O.A. Yepanchintseva B.M. Todurov |
| author_facet | I.V. Shklianka O.J. Zharinov К.O. Mikhaliev O.A. Yepanchintseva B.M. Todurov |
| author_sort | I.V. Shklianka |
| collection | DOAJ |
| description | The aim – to evaluate the efficacy and safety of perioperative statins treatment during coronary artery bypass graft surgery (CABG).
Materials and methods. The data from clinical and instrumental examination of 155 patients with stable coronary heart disease (CHD) consecutively selected for CABG surgery were analyzed in a single-center study. Depending on perioperative statins usage, patients were retrospectively divided into three groups: group one – did not receive statins at least one week before surgery (n = 30), group two – received statins in moderate or low doses (n = 107), group three – received statins in high doses for at least one week before surgery (n = 18). Patients receiving high-intensity statin therapy for less than 7 days prior to surgery were included in group two.
Results The clinical groups had no significant differences in concomitant diseases and demographic parameters. Postoperative complications occurred in total in 66 (42.6 %) patients. The lack of perioperative statin therapy was associated with a more frequent occurrence of postoperative complications compared with statins in moderate and high doses (73 %, 36 %, 28 % of patients in clinical groups, respectively, р1-2 = 0.003, р1-3 = 0.018). The incidence of postoperative atrial fibrillation was significantly lower in groups two and three, compared to group one (р1–2 < 0.001 and р1–3 < 0.001). In group one there were 4 cases of acute heart failure, one case of acute myocardial infarction, one acute respiratory failure and one significant blockade, which required the implantation of a pacemaker, while in other groups such cases were not recorded. Cases of acute kidney damage were noted with the same frequency in groups two and three (by 10 %), in group three – were not registered. There were no significant differences in groups regarding serum transaminases.
Conclusions The lack of perioperative statin therapy is associated with higher incidence of postoperative complications. Perioperative statin initiation was associated with decrease in the frequency of postoperative atrial fibrillation and not accompanied by significant changes of liver and kidney markers dysfunction, including group of patients receiving high doses of statins. |
| format | Article |
| id | doaj-art-1e91acc8969848b2a7259961d934594a |
| institution | Kabale University |
| issn | 2305-3127 |
| language | English |
| publishDate | 2018-03-01 |
| publisher | TOV Chetverta Khvylia |
| record_format | Article |
| series | Кардіохірургія та інтервенційна кардіологія |
| spelling | doaj-art-1e91acc8969848b2a7259961d934594a2025-02-03T02:03:24ZengTOV Chetverta KhvyliaКардіохірургія та інтервенційна кардіологія2305-31272018-03-011201424The efficacy and safety of peroperative statin treatment during coronary artery bypass graftingI.V. Shklianka0O.J. Zharinov1К.O. Mikhaliev2O.A. Yepanchintseva3B.M. Todurov4Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine, Heart Institute of Healthcare Ministry of Ukraine, Kyiv, UkraineShupyk National Medical Academy of Postgraduate Education, Kyiv, UkraineState Scientific Institution «Scientific and Practical Center of Preventive and Clinical Medicine» State Government Affairs, Kyiv, UkraineShupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine, Heart Institute of Healthcare Ministry of Ukraine, Kyiv, UkraineShupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine, Heart Institute of Healthcare Ministry of Ukraine, Kyiv, UkraineThe aim – to evaluate the efficacy and safety of perioperative statins treatment during coronary artery bypass graft surgery (CABG). Materials and methods. The data from clinical and instrumental examination of 155 patients with stable coronary heart disease (CHD) consecutively selected for CABG surgery were analyzed in a single-center study. Depending on perioperative statins usage, patients were retrospectively divided into three groups: group one – did not receive statins at least one week before surgery (n = 30), group two – received statins in moderate or low doses (n = 107), group three – received statins in high doses for at least one week before surgery (n = 18). Patients receiving high-intensity statin therapy for less than 7 days prior to surgery were included in group two. Results The clinical groups had no significant differences in concomitant diseases and demographic parameters. Postoperative complications occurred in total in 66 (42.6 %) patients. The lack of perioperative statin therapy was associated with a more frequent occurrence of postoperative complications compared with statins in moderate and high doses (73 %, 36 %, 28 % of patients in clinical groups, respectively, р1-2 = 0.003, р1-3 = 0.018). The incidence of postoperative atrial fibrillation was significantly lower in groups two and three, compared to group one (р1–2 < 0.001 and р1–3 < 0.001). In group one there were 4 cases of acute heart failure, one case of acute myocardial infarction, one acute respiratory failure and one significant blockade, which required the implantation of a pacemaker, while in other groups such cases were not recorded. Cases of acute kidney damage were noted with the same frequency in groups two and three (by 10 %), in group three – were not registered. There were no significant differences in groups regarding serum transaminases. Conclusions The lack of perioperative statin therapy is associated with higher incidence of postoperative complications. Perioperative statin initiation was associated with decrease in the frequency of postoperative atrial fibrillation and not accompanied by significant changes of liver and kidney markers dysfunction, including group of patients receiving high doses of statins.http://csic.com.ua/images/pdf/2018/1-2018/efficacy-safety-of-peroperative-statin-treatment-during-coronary-artery-bypass-grafting.pdfcoronary artery bypass graft surgerystatinsperioperative periodcomplications |
| spellingShingle | I.V. Shklianka O.J. Zharinov К.O. Mikhaliev O.A. Yepanchintseva B.M. Todurov The efficacy and safety of peroperative statin treatment during coronary artery bypass grafting Кардіохірургія та інтервенційна кардіологія coronary artery bypass graft surgery statins perioperative period complications |
| title | The efficacy and safety of peroperative statin treatment during coronary artery bypass grafting |
| title_full | The efficacy and safety of peroperative statin treatment during coronary artery bypass grafting |
| title_fullStr | The efficacy and safety of peroperative statin treatment during coronary artery bypass grafting |
| title_full_unstemmed | The efficacy and safety of peroperative statin treatment during coronary artery bypass grafting |
| title_short | The efficacy and safety of peroperative statin treatment during coronary artery bypass grafting |
| title_sort | efficacy and safety of peroperative statin treatment during coronary artery bypass grafting |
| topic | coronary artery bypass graft surgery statins perioperative period complications |
| url | http://csic.com.ua/images/pdf/2018/1-2018/efficacy-safety-of-peroperative-statin-treatment-during-coronary-artery-bypass-grafting.pdf |
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