Geometrical isomers of lutein and fucoxanthin: Unveiling their antioxidant potentials and skin-related biological activities
Although carotenoids are most commonly found in dietary sources as all-E-isomers, some carotenoids accumulate in the skin as Z-isomers; their roles are largely unknown. This study investigated the effects of E/Z-isomers of lutein and fucoxanthin, two xanthophyll carotenoids, on their antioxidant pot...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-12-01
|
| Series: | Food Chemistry Advances |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772753X24002120 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850061385687367680 |
|---|---|
| author | Sujan Banik Antara Ghosh Tomoyuki Takano Masao Tsukamoto Soo Takasu Masaki Honda |
| author_facet | Sujan Banik Antara Ghosh Tomoyuki Takano Masao Tsukamoto Soo Takasu Masaki Honda |
| author_sort | Sujan Banik |
| collection | DOAJ |
| description | Although carotenoids are most commonly found in dietary sources as all-E-isomers, some carotenoids accumulate in the skin as Z-isomers; their roles are largely unknown. This study investigated the effects of E/Z-isomers of lutein and fucoxanthin, two xanthophyll carotenoids, on their antioxidant potential and skin-related biological activities. Evaluation of ultraviolet (UV)-blocking abilities demonstrated the superior performance of Z-isomer-rich lutein and fucoxanthin against UV-A and UV-B radiation, with Z-isomer-rich lutein exhibiting higher UV-B protection. Antioxidant assays revealed that all-E- and Z-isomer-rich lutein and fucoxanthin had potent singlet oxygen and hydroxyl radical scavenging activities. Moreover, Z-isomer-rich lutein and fucoxanthin exhibited enhanced lipid peroxidation scavenging compared with their all-E counterparts. Both isomers of lutein and fucoxanthin exhibited potent skin-antiaging and skin-whitening effects in several in vitro assays, including anti-elastase and anti-tyrosinase activities. These findings suggest that geometric isomers may enhance the therapeutic efficacy of carotenoids in skin care applications. |
| format | Article |
| id | doaj-art-1e867185d24c44209e8fecff0a13d4d1 |
| institution | DOAJ |
| issn | 2772-753X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Food Chemistry Advances |
| spelling | doaj-art-1e867185d24c44209e8fecff0a13d4d12025-08-20T02:50:16ZengElsevierFood Chemistry Advances2772-753X2024-12-01510081710.1016/j.focha.2024.100817Geometrical isomers of lutein and fucoxanthin: Unveiling their antioxidant potentials and skin-related biological activitiesSujan Banik0Antara Ghosh1Tomoyuki Takano2Masao Tsukamoto3Soo Takasu4Masaki Honda5Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali 3814, Bangladesh; Corresponding authors.Department of Chemistry, Faculty of Science & Technology, Meijo University, 1-501 Shiogamaguchi, Tempaku-ku, Nagoya, Aichi 468-8502, JapanR&D Center, Alnur Co., Ltd., 1-25-3 Takada, Toyoshima-ku, Tokyo 171-0033, JapanR&D Center, Alnur Co., Ltd., 1-25-3 Takada, Toyoshima-ku, Tokyo 171-0033, JapanLaboratory of Pharmaceutical Analytical Chemistry, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu-shi, Gifu 501-1196, JapanDepartment of Chemistry, Faculty of Science & Technology, Meijo University, 1-501 Shiogamaguchi, Tempaku-ku, Nagoya, Aichi 468-8502, Japan; Graduate School of Environmental and Human Sciences, Meijo University, 1-501 Shiogamaguchi, Tempaku-ku, Nagoya, Aichi 468-8502, Japan; Corresponding author at: Department of Chemistry, Faculty of Science & Technology, Meijo University, 1-501 Shiogamaguchi, Tempaku-ku, Nagoya, Aichi 468-8502, Japan.Although carotenoids are most commonly found in dietary sources as all-E-isomers, some carotenoids accumulate in the skin as Z-isomers; their roles are largely unknown. This study investigated the effects of E/Z-isomers of lutein and fucoxanthin, two xanthophyll carotenoids, on their antioxidant potential and skin-related biological activities. Evaluation of ultraviolet (UV)-blocking abilities demonstrated the superior performance of Z-isomer-rich lutein and fucoxanthin against UV-A and UV-B radiation, with Z-isomer-rich lutein exhibiting higher UV-B protection. Antioxidant assays revealed that all-E- and Z-isomer-rich lutein and fucoxanthin had potent singlet oxygen and hydroxyl radical scavenging activities. Moreover, Z-isomer-rich lutein and fucoxanthin exhibited enhanced lipid peroxidation scavenging compared with their all-E counterparts. Both isomers of lutein and fucoxanthin exhibited potent skin-antiaging and skin-whitening effects in several in vitro assays, including anti-elastase and anti-tyrosinase activities. These findings suggest that geometric isomers may enhance the therapeutic efficacy of carotenoids in skin care applications.http://www.sciencedirect.com/science/article/pii/S2772753X24002120Antioxidant activityCarotenoidFucoxanthinLuteinSkin antiaging activitySkin-whitening activity |
| spellingShingle | Sujan Banik Antara Ghosh Tomoyuki Takano Masao Tsukamoto Soo Takasu Masaki Honda Geometrical isomers of lutein and fucoxanthin: Unveiling their antioxidant potentials and skin-related biological activities Food Chemistry Advances Antioxidant activity Carotenoid Fucoxanthin Lutein Skin antiaging activity Skin-whitening activity |
| title | Geometrical isomers of lutein and fucoxanthin: Unveiling their antioxidant potentials and skin-related biological activities |
| title_full | Geometrical isomers of lutein and fucoxanthin: Unveiling their antioxidant potentials and skin-related biological activities |
| title_fullStr | Geometrical isomers of lutein and fucoxanthin: Unveiling their antioxidant potentials and skin-related biological activities |
| title_full_unstemmed | Geometrical isomers of lutein and fucoxanthin: Unveiling their antioxidant potentials and skin-related biological activities |
| title_short | Geometrical isomers of lutein and fucoxanthin: Unveiling their antioxidant potentials and skin-related biological activities |
| title_sort | geometrical isomers of lutein and fucoxanthin unveiling their antioxidant potentials and skin related biological activities |
| topic | Antioxidant activity Carotenoid Fucoxanthin Lutein Skin antiaging activity Skin-whitening activity |
| url | http://www.sciencedirect.com/science/article/pii/S2772753X24002120 |
| work_keys_str_mv | AT sujanbanik geometricalisomersofluteinandfucoxanthinunveilingtheirantioxidantpotentialsandskinrelatedbiologicalactivities AT antaraghosh geometricalisomersofluteinandfucoxanthinunveilingtheirantioxidantpotentialsandskinrelatedbiologicalactivities AT tomoyukitakano geometricalisomersofluteinandfucoxanthinunveilingtheirantioxidantpotentialsandskinrelatedbiologicalactivities AT masaotsukamoto geometricalisomersofluteinandfucoxanthinunveilingtheirantioxidantpotentialsandskinrelatedbiologicalactivities AT sootakasu geometricalisomersofluteinandfucoxanthinunveilingtheirantioxidantpotentialsandskinrelatedbiologicalactivities AT masakihonda geometricalisomersofluteinandfucoxanthinunveilingtheirantioxidantpotentialsandskinrelatedbiologicalactivities |