Personality Changes after Deep Brain Stimulation in Parkinson’s Disease
Objectives. Deep brain stimulation of the subthalamic nucleus (STN-DBS) is a recognized therapy that improves motor symptoms in advanced Parkinson’s disease (PD). However, little is known about its impact on personality. To address this topic, we have assessed personality traits before and after STN...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2015/490507 |
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| author | Uyen Pham Anne-Kristin Solbakk Inger-Marie Skogseid Mathias Toft Are Hugo Pripp Ane Eidahl Konglund Stein Andersson Ira Ronit Haraldsen Dag Aarsland Espen Dietrichs Ulrik Fredrik Malt |
| author_facet | Uyen Pham Anne-Kristin Solbakk Inger-Marie Skogseid Mathias Toft Are Hugo Pripp Ane Eidahl Konglund Stein Andersson Ira Ronit Haraldsen Dag Aarsland Espen Dietrichs Ulrik Fredrik Malt |
| author_sort | Uyen Pham |
| collection | DOAJ |
| description | Objectives. Deep brain stimulation of the subthalamic nucleus (STN-DBS) is a recognized therapy that improves motor symptoms in advanced Parkinson’s disease (PD). However, little is known about its impact on personality. To address this topic, we have assessed personality traits before and after STN-DBS in PD patients. Methods. Forty patients with advanced PD were assessed with the Temperament and Character Inventory (TCI): the Urgency, Premeditation, Perseverance, Sensation Seeking impulsive behaviour scale (UPPS), and the Neuroticism and Lie subscales of the Eysenck Personality Questionnaire (EPQ-N, EPQ-L) before surgery and after three months of STN-DBS. Collateral information obtained from the UPPS was also reported. Results. Despite improvement in motor function and reduction in dopaminergic dosage patients reported lower score on the TCI Persistence and Self-Transcendence scales, after three months of STN-DBS, compared to baseline (P=0.006; P=0.024). Relatives reported significantly increased scores on the UPPS Lack of Premeditation scale at follow-up (P=0.027). Conclusion. STN-DBS in PD patients is associated with personality changes in the direction of increased impulsivity. |
| format | Article |
| id | doaj-art-1e851481710043eea6b1c46c5e0e747c |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-1e851481710043eea6b1c46c5e0e747c2025-02-03T07:25:58ZengWileyParkinson's Disease2090-80832042-00802015-01-01201510.1155/2015/490507490507Personality Changes after Deep Brain Stimulation in Parkinson’s DiseaseUyen Pham0Anne-Kristin Solbakk1Inger-Marie Skogseid2Mathias Toft3Are Hugo Pripp4Ane Eidahl Konglund5Stein Andersson6Ira Ronit Haraldsen7Dag Aarsland8Espen Dietrichs9Ulrik Fredrik Malt10Department of Neuropsychiatry and Psychosomatic Medicine, Oslo University Hospital-Rikshospitalet, 0027 Oslo, NorwayDepartment of Neuropsychiatry and Psychosomatic Medicine, Oslo University Hospital-Rikshospitalet, 0027 Oslo, NorwayDepartment of Neurology, Oslo University Hospital-Rikshospitalet, 0027 Oslo, NorwayDepartment of Neurology, Oslo University Hospital-Rikshospitalet, 0027 Oslo, NorwayDepartment of Biostatistics and Epidemiology, Oslo University Hospital-Rikshospitalet, 0450 Oslo, NorwayDepartment of Neurosurgery, Oslo University Hospital-Rikshospitalet, 0027 Oslo, NorwayDepartment of Neuropsychiatry and Psychosomatic Medicine, Oslo University Hospital-Rikshospitalet, 0027 Oslo, NorwayDepartment of Neuropsychiatry and Psychosomatic Medicine, Oslo University Hospital-Rikshospitalet, 0027 Oslo, NorwayCentre for Age-Related Medicine, Stavanger University Hospital, 4068 Stavanger, NorwayInstitute of Clinical Medicine, University of Oslo, 0316 Oslo, NorwayDepartment of Neuropsychiatry and Psychosomatic Medicine, Oslo University Hospital-Rikshospitalet, 0027 Oslo, NorwayObjectives. Deep brain stimulation of the subthalamic nucleus (STN-DBS) is a recognized therapy that improves motor symptoms in advanced Parkinson’s disease (PD). However, little is known about its impact on personality. To address this topic, we have assessed personality traits before and after STN-DBS in PD patients. Methods. Forty patients with advanced PD were assessed with the Temperament and Character Inventory (TCI): the Urgency, Premeditation, Perseverance, Sensation Seeking impulsive behaviour scale (UPPS), and the Neuroticism and Lie subscales of the Eysenck Personality Questionnaire (EPQ-N, EPQ-L) before surgery and after three months of STN-DBS. Collateral information obtained from the UPPS was also reported. Results. Despite improvement in motor function and reduction in dopaminergic dosage patients reported lower score on the TCI Persistence and Self-Transcendence scales, after three months of STN-DBS, compared to baseline (P=0.006; P=0.024). Relatives reported significantly increased scores on the UPPS Lack of Premeditation scale at follow-up (P=0.027). Conclusion. STN-DBS in PD patients is associated with personality changes in the direction of increased impulsivity.http://dx.doi.org/10.1155/2015/490507 |
| spellingShingle | Uyen Pham Anne-Kristin Solbakk Inger-Marie Skogseid Mathias Toft Are Hugo Pripp Ane Eidahl Konglund Stein Andersson Ira Ronit Haraldsen Dag Aarsland Espen Dietrichs Ulrik Fredrik Malt Personality Changes after Deep Brain Stimulation in Parkinson’s Disease Parkinson's Disease |
| title | Personality Changes after Deep Brain Stimulation in Parkinson’s Disease |
| title_full | Personality Changes after Deep Brain Stimulation in Parkinson’s Disease |
| title_fullStr | Personality Changes after Deep Brain Stimulation in Parkinson’s Disease |
| title_full_unstemmed | Personality Changes after Deep Brain Stimulation in Parkinson’s Disease |
| title_short | Personality Changes after Deep Brain Stimulation in Parkinson’s Disease |
| title_sort | personality changes after deep brain stimulation in parkinson s disease |
| url | http://dx.doi.org/10.1155/2015/490507 |
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