HMGA1 deficiency: a pathogenic link between tau pathology and insulin resistanceResearch in context

HMGA1 deficiency: a pathogenic link between tau pathology and insulin resistanceResearch in context

Summary: Background: Growing evidence links tau-related neurodegeneration with insulin resistance and type 2 diabetes (T2D), though the underlying mechanisms remain unclear. Our previous research identified HMGA1 as crucial for insulin receptor (INSR) expression, with defects in the HMGA1 gene asso...

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Main Authors: Maria Mirabelli, Eusebio Chiefari, Biagio Arcidiacono, Alessandro Salatino, Angelo Pascarella, Maurizio Morelli, Sara C. Credendino, Francesco S. Brunetti, Anna Di Vito, Adelaide Greco, Vincent Huin, Ferdinando Nicoletti, Giovanna M. Pierantoni, Monica Fedele, Umberto Aguglia, Daniela P. Foti, Antonio Brunetti
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:EBioMedicine
Subjects:
Neurodegeneration
Insulin resistance
Glucose metabolism
Gene transcription
HMGA1
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396425001446
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