Bone Mineral Status in Children and Adolescents with Klinefelter Syndrome
Objective. Klinefelter syndrome (KS) has long-term consequences on bone health. However, studies regarding bone status and metabolism during childhood and adolescence are very rare. Patients. This cross-sectional study involved 40 (mean age: 13.7±3.8 years) KS children and adolescents and 80 age-mat...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/3032759 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564807157415936 |
|---|---|
| author | Stefano Stagi Mariarosaria Di Tommaso Cristina Manoni Perla Scalini Francesco Chiarelli Alberto Verrotti Elisabetta Lapi Sabrina Giglio Laura Dosa Maurizio de Martino |
| author_facet | Stefano Stagi Mariarosaria Di Tommaso Cristina Manoni Perla Scalini Francesco Chiarelli Alberto Verrotti Elisabetta Lapi Sabrina Giglio Laura Dosa Maurizio de Martino |
| author_sort | Stefano Stagi |
| collection | DOAJ |
| description | Objective. Klinefelter syndrome (KS) has long-term consequences on bone health. However, studies regarding bone status and metabolism during childhood and adolescence are very rare. Patients. This cross-sectional study involved 40 (mean age: 13.7±3.8 years) KS children and adolescents and 80 age-matched healthy subjects. For both patient and control groups, we evaluated serum levels of ionised and total calcium, phosphate, total testosterone, luteinising hormone, follicle stimulating hormone, parathyroid hormone (PTH), 25-hydroxyvitamin D (25(OH)D), 1,25-dihydroxyvitamin D, osteocalcin, bone alkaline phosphatase, and urinary deoxypyridinoline concentrations. We also calculated the z-scores of the phalangeal amplitude-dependent speed of sound (AD-SoS) and the bone transmission time (BTT). Results. KS children and adolescents showed significantly reduced AD-SoS (p<0.005) and BTT (p<0.0005) z-scores compared to the controls. However, KS patients presented significantly higher PTH (p<0.0001) and significantly lower 25(OH)D (p<0.0001), osteocalcin (p<0.05), and bone alkaline phosphatase levels (p<0.005). Interestingly, these metabolic bone disorders were already present in the prepubertal subjects. Conclusions. KS children and adolescents exhibited impaired bone mineral status and metabolism with higher PTH levels and a significant reduction of 25-OH-D and bone formation markers. Interestingly, this impairment was already evident in prepubertal KS patients. Follow-ups should be scheduled with KS patients to investigate and ameliorate bone mineral status and metabolism until the prepubertal ages. |
| format | Article |
| id | doaj-art-1e74b98f648141ee81e19d043eaf16e9 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-1e74b98f648141ee81e19d043eaf16e92025-02-03T01:10:06ZengWileyInternational Journal of Endocrinology1687-83371687-83452016-01-01201610.1155/2016/30327593032759Bone Mineral Status in Children and Adolescents with Klinefelter SyndromeStefano Stagi0Mariarosaria Di Tommaso1Cristina Manoni2Perla Scalini3Francesco Chiarelli4Alberto Verrotti5Elisabetta Lapi6Sabrina Giglio7Laura Dosa8Maurizio de Martino9Department of Health Sciences, University of Florence, Anna Meyer Children’s University Hospital, 50139 Florence, ItalyDepartment of Health Sciences, University of Florence, Careggi Hospital, 50134 Florence, ItalyDepartment of Health Sciences, University of Florence, Anna Meyer Children’s University Hospital, 50139 Florence, ItalyDepartment of Health Sciences, University of Florence, Anna Meyer Children’s University Hospital, 50139 Florence, ItalyDepartment of Paediatrics, University of Chieti, 66100 Chieti, ItalyDepartment of Paediatrics, University of L’Aquila, 67100 L’Aquila, ItalyGenetics and Molecular Medicine Unit, Anna Meyer Children’s University Hospital, 50139 Florence, ItalyGenetics and Molecular Medicine Unit, Anna Meyer Children’s University Hospital, 50139 Florence, ItalyGenetics and Molecular Medicine Unit, Anna Meyer Children’s University Hospital, 50139 Florence, ItalyDepartment of Health Sciences, University of Florence, Anna Meyer Children’s University Hospital, 50139 Florence, ItalyObjective. Klinefelter syndrome (KS) has long-term consequences on bone health. However, studies regarding bone status and metabolism during childhood and adolescence are very rare. Patients. This cross-sectional study involved 40 (mean age: 13.7±3.8 years) KS children and adolescents and 80 age-matched healthy subjects. For both patient and control groups, we evaluated serum levels of ionised and total calcium, phosphate, total testosterone, luteinising hormone, follicle stimulating hormone, parathyroid hormone (PTH), 25-hydroxyvitamin D (25(OH)D), 1,25-dihydroxyvitamin D, osteocalcin, bone alkaline phosphatase, and urinary deoxypyridinoline concentrations. We also calculated the z-scores of the phalangeal amplitude-dependent speed of sound (AD-SoS) and the bone transmission time (BTT). Results. KS children and adolescents showed significantly reduced AD-SoS (p<0.005) and BTT (p<0.0005) z-scores compared to the controls. However, KS patients presented significantly higher PTH (p<0.0001) and significantly lower 25(OH)D (p<0.0001), osteocalcin (p<0.05), and bone alkaline phosphatase levels (p<0.005). Interestingly, these metabolic bone disorders were already present in the prepubertal subjects. Conclusions. KS children and adolescents exhibited impaired bone mineral status and metabolism with higher PTH levels and a significant reduction of 25-OH-D and bone formation markers. Interestingly, this impairment was already evident in prepubertal KS patients. Follow-ups should be scheduled with KS patients to investigate and ameliorate bone mineral status and metabolism until the prepubertal ages.http://dx.doi.org/10.1155/2016/3032759 |
| spellingShingle | Stefano Stagi Mariarosaria Di Tommaso Cristina Manoni Perla Scalini Francesco Chiarelli Alberto Verrotti Elisabetta Lapi Sabrina Giglio Laura Dosa Maurizio de Martino Bone Mineral Status in Children and Adolescents with Klinefelter Syndrome International Journal of Endocrinology |
| title | Bone Mineral Status in Children and Adolescents with Klinefelter Syndrome |
| title_full | Bone Mineral Status in Children and Adolescents with Klinefelter Syndrome |
| title_fullStr | Bone Mineral Status in Children and Adolescents with Klinefelter Syndrome |
| title_full_unstemmed | Bone Mineral Status in Children and Adolescents with Klinefelter Syndrome |
| title_short | Bone Mineral Status in Children and Adolescents with Klinefelter Syndrome |
| title_sort | bone mineral status in children and adolescents with klinefelter syndrome |
| url | http://dx.doi.org/10.1155/2016/3032759 |
| work_keys_str_mv | AT stefanostagi bonemineralstatusinchildrenandadolescentswithklinefeltersyndrome AT mariarosariaditommaso bonemineralstatusinchildrenandadolescentswithklinefeltersyndrome AT cristinamanoni bonemineralstatusinchildrenandadolescentswithklinefeltersyndrome AT perlascalini bonemineralstatusinchildrenandadolescentswithklinefeltersyndrome AT francescochiarelli bonemineralstatusinchildrenandadolescentswithklinefeltersyndrome AT albertoverrotti bonemineralstatusinchildrenandadolescentswithklinefeltersyndrome AT elisabettalapi bonemineralstatusinchildrenandadolescentswithklinefeltersyndrome AT sabrinagiglio bonemineralstatusinchildrenandadolescentswithklinefeltersyndrome AT lauradosa bonemineralstatusinchildrenandadolescentswithklinefeltersyndrome AT mauriziodemartino bonemineralstatusinchildrenandadolescentswithklinefeltersyndrome |