Premalignant Lesions in the Kidney
Renal cell carcinoma (RCC) is the most malignant urologic disease. Different lesions, such as dysplasia in the tubules adjacent to RCC, atypical hyperplasia in the cyst epithelium of von Hippel-Lindau syndrome, and adenoma have been described for a number of years as possible premalignant changes or...
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| Format: | Article |
| Language: | English |
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Wiley
2001-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2001.321 |
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| author | Ziva Kirkali Kutsal Yorukoglu |
| author_facet | Ziva Kirkali Kutsal Yorukoglu |
| author_sort | Ziva Kirkali |
| collection | DOAJ |
| description | Renal cell carcinoma (RCC) is the most malignant urologic disease. Different lesions, such as dysplasia in the tubules adjacent to RCC, atypical hyperplasia in the cyst epithelium of von Hippel-Lindau syndrome, and adenoma have been described for a number of years as possible premalignant changes or precursor lesions of RCC. In two recent papers, kidneys adjacent to RCC or removed from other causes were analyzed, and dysplastic lesions were identified and defined in detail. Currently renal intraepithelial neoplasia (RIN) is the proposed term for classification. The criteria for a lesion to be defined as premalignant are (1) morphological similarity; (2) spatial association; (3) development of microinvasive carcinoma; (4) higher frequency, severity, and extent then invasive carcinoma; (5) progression to invasive cancer; and (6) similar genetic alterations. RIN resembles the neoplastic cells of RCC. There is spatial association. Progression to invasive carcinoma is described in experimental cancer models, and in some human renal tumors. Similar molecular alterations are found in some putative premalignant changes. The treatment for RCC is radical or partial nephrectomy. Preneoplastic lesions may remain in the renal remnant in patients treated by partial nephrectomy and may be the source of local recurrences. RIN seems to be a biologic precursor of some RCCs and warrants further investigation. Interpretation and reporting of these lesions would reveal important resources for the biological nature and clinical significance. The management of RIN diagnosed in a renal biopsy and partial nephrectomy needs to be answered. |
| format | Article |
| id | doaj-art-1e6023e1768a43659af32c1272c889e8 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2001-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-1e6023e1768a43659af32c1272c889e82025-02-03T05:54:28ZengWileyThe Scientific World Journal1537-744X2001-01-01185586710.1100/tsw.2001.321Premalignant Lesions in the KidneyZiva Kirkali0Kutsal Yorukoglu1Department of Urology, Eylul University, School of Medicine, 35340 Inciralti, Izmir, TurkeyDepartment of Urology, Eylul University, School of Medicine, 35340 Inciralti, Izmir, TurkeyRenal cell carcinoma (RCC) is the most malignant urologic disease. Different lesions, such as dysplasia in the tubules adjacent to RCC, atypical hyperplasia in the cyst epithelium of von Hippel-Lindau syndrome, and adenoma have been described for a number of years as possible premalignant changes or precursor lesions of RCC. In two recent papers, kidneys adjacent to RCC or removed from other causes were analyzed, and dysplastic lesions were identified and defined in detail. Currently renal intraepithelial neoplasia (RIN) is the proposed term for classification. The criteria for a lesion to be defined as premalignant are (1) morphological similarity; (2) spatial association; (3) development of microinvasive carcinoma; (4) higher frequency, severity, and extent then invasive carcinoma; (5) progression to invasive cancer; and (6) similar genetic alterations. RIN resembles the neoplastic cells of RCC. There is spatial association. Progression to invasive carcinoma is described in experimental cancer models, and in some human renal tumors. Similar molecular alterations are found in some putative premalignant changes. The treatment for RCC is radical or partial nephrectomy. Preneoplastic lesions may remain in the renal remnant in patients treated by partial nephrectomy and may be the source of local recurrences. RIN seems to be a biologic precursor of some RCCs and warrants further investigation. Interpretation and reporting of these lesions would reveal important resources for the biological nature and clinical significance. The management of RIN diagnosed in a renal biopsy and partial nephrectomy needs to be answered.http://dx.doi.org/10.1100/tsw.2001.321 |
| spellingShingle | Ziva Kirkali Kutsal Yorukoglu Premalignant Lesions in the Kidney The Scientific World Journal |
| title | Premalignant Lesions in the Kidney |
| title_full | Premalignant Lesions in the Kidney |
| title_fullStr | Premalignant Lesions in the Kidney |
| title_full_unstemmed | Premalignant Lesions in the Kidney |
| title_short | Premalignant Lesions in the Kidney |
| title_sort | premalignant lesions in the kidney |
| url | http://dx.doi.org/10.1100/tsw.2001.321 |
| work_keys_str_mv | AT zivakirkali premalignantlesionsinthekidney AT kutsalyorukoglu premalignantlesionsinthekidney |