Antioxidant, Anti-Inflammatory, and Oral Bioavailability of Novel Sulfonamide Derivatives of Gallic Acid

Antioxidant, Anti-Inflammatory, and Oral Bioavailability of Novel Sulfonamide Derivatives of Gallic Acid

Gallic acid (GA) is known for its antioxidant and anti-inflammatory properties, yet its clinical potential is hindered due to poor oral bioavailability. This study investigates novel GA sulfonamide derivatives, 3,4,5-trimethoxybenzenesulfonamide (3,4,5-TMBS) and 3,4,5-trihydroxybenzenesulfonamide (3...

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Bibliographic Details
Main Authors: Dania Alhyari, Nidal A. Qinna, Helen M. Sheldrake, Sriharsha Kantamneni, Bayan Y. Ghanem, Krzysztof J. Paluch
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Antioxidants
Subjects:
3,4,5-TMBS
3,4,5-THBS
cytochrome P450
COX-2 inhibition
pharmacokinetics
rat model
Online Access:https://www.mdpi.com/2076-3921/14/4/374
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