Galactose-Deficient IgA1 Deposits in Clear Cell Renal Cell Carcinoma-Related Henoch–Schönlein Purpura Nephritis
Recent studies suggest that galactose-deficient IgA1 (Gd-IgA1) plays a role in the pathogenesis of primary IgA nephropathy (IgAN) and Henoch–Schönlein purpura nephritis (HSPN). Furthermore, immunostaining of KM55, an antibody that identifies Gd-IgA1, may be helpful to differentiate primary IgAN and...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2020/8828336 |
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| author | Yuhong Zhao Youngki Kim Milind Junghare Viral Vakil Xuesong Su Faqian Li Lihong Bu |
| author_facet | Yuhong Zhao Youngki Kim Milind Junghare Viral Vakil Xuesong Su Faqian Li Lihong Bu |
| author_sort | Yuhong Zhao |
| collection | DOAJ |
| description | Recent studies suggest that galactose-deficient IgA1 (Gd-IgA1) plays a role in the pathogenesis of primary IgA nephropathy (IgAN) and Henoch–Schönlein purpura nephritis (HSPN). Furthermore, immunostaining of KM55, an antibody that identifies Gd-IgA1, may be helpful to differentiate primary IgAN and HSPN from secondary causes of glomerular IgA deposition. We report sequential kidney biopsies of a malignancy-associated HSPN, showing intense glomerular mesangial IgA deposition at the initial kidney biopsy and dramatic decrease in disappearance of glomerular deposits after tumor removal. We demonstrate that the glomerular IgA deposition contains Gd-IgA1, detected by immunostaining of KM55, with similar distribution and intensity to IgA. This suggests that renal Gd-IgA1 deposition may play a role in the pathogenesis of malignancy-associated HSPN. |
| format | Article |
| id | doaj-art-1e4366eab3064ef58eb2ba0655376723 |
| institution | Kabale University |
| issn | 2090-6641 2090-665X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Nephrology |
| spelling | doaj-art-1e4366eab3064ef58eb2ba06553767232025-02-03T00:58:44ZengWileyCase Reports in Nephrology2090-66412090-665X2020-01-01202010.1155/2020/88283368828336Galactose-Deficient IgA1 Deposits in Clear Cell Renal Cell Carcinoma-Related Henoch–Schönlein Purpura NephritisYuhong Zhao0Youngki Kim1Milind Junghare2Viral Vakil3Xuesong Su4Faqian Li5Lihong Bu6Department of Nephrology, Central Hospital Affiliated to Shenyang Medical College, Shenyang, Liaoning 110024, ChinaDepartment of Pediatrics, Division of Pediatric Nephrology, University of Minnesota, Minneapolis, MN 55455, USADepartment of Renal Disease and Hypertension, University of Minnesota, Minneapolis, MN 55455, USADepartment of Renal Disease and Hypertension, University of Minnesota, Minneapolis, MN 55455, USADepartment of Nephrology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, ChinaDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USADepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USARecent studies suggest that galactose-deficient IgA1 (Gd-IgA1) plays a role in the pathogenesis of primary IgA nephropathy (IgAN) and Henoch–Schönlein purpura nephritis (HSPN). Furthermore, immunostaining of KM55, an antibody that identifies Gd-IgA1, may be helpful to differentiate primary IgAN and HSPN from secondary causes of glomerular IgA deposition. We report sequential kidney biopsies of a malignancy-associated HSPN, showing intense glomerular mesangial IgA deposition at the initial kidney biopsy and dramatic decrease in disappearance of glomerular deposits after tumor removal. We demonstrate that the glomerular IgA deposition contains Gd-IgA1, detected by immunostaining of KM55, with similar distribution and intensity to IgA. This suggests that renal Gd-IgA1 deposition may play a role in the pathogenesis of malignancy-associated HSPN.http://dx.doi.org/10.1155/2020/8828336 |
| spellingShingle | Yuhong Zhao Youngki Kim Milind Junghare Viral Vakil Xuesong Su Faqian Li Lihong Bu Galactose-Deficient IgA1 Deposits in Clear Cell Renal Cell Carcinoma-Related Henoch–Schönlein Purpura Nephritis Case Reports in Nephrology |
| title | Galactose-Deficient IgA1 Deposits in Clear Cell Renal Cell Carcinoma-Related Henoch–Schönlein Purpura Nephritis |
| title_full | Galactose-Deficient IgA1 Deposits in Clear Cell Renal Cell Carcinoma-Related Henoch–Schönlein Purpura Nephritis |
| title_fullStr | Galactose-Deficient IgA1 Deposits in Clear Cell Renal Cell Carcinoma-Related Henoch–Schönlein Purpura Nephritis |
| title_full_unstemmed | Galactose-Deficient IgA1 Deposits in Clear Cell Renal Cell Carcinoma-Related Henoch–Schönlein Purpura Nephritis |
| title_short | Galactose-Deficient IgA1 Deposits in Clear Cell Renal Cell Carcinoma-Related Henoch–Schönlein Purpura Nephritis |
| title_sort | galactose deficient iga1 deposits in clear cell renal cell carcinoma related henoch schonlein purpura nephritis |
| url | http://dx.doi.org/10.1155/2020/8828336 |
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