High Quality–Factor All–Dielectric Metacavity for Label–Free Biosensing
Abstract High sensitivity and high quality‐factor are crucial for achieving outstanding sensing performance in photonic biosensors. However, strong optical field confinement and high light–biomolecule interactions on photonic surfaces are usually contradictory and challenging to satisfy simultaneous...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202410125 |
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| author | Yuqiao Zheng Jiacheng Sun Yaqing Ma Hongyong Zhang Zhen Cui Giannis G. Paschos Xixi Song Ying Tao Pavlos Savvidis Wei Kong Liaoyong Wen Sumin Bian Mohamad Sawan |
| author_facet | Yuqiao Zheng Jiacheng Sun Yaqing Ma Hongyong Zhang Zhen Cui Giannis G. Paschos Xixi Song Ying Tao Pavlos Savvidis Wei Kong Liaoyong Wen Sumin Bian Mohamad Sawan |
| author_sort | Yuqiao Zheng |
| collection | DOAJ |
| description | Abstract High sensitivity and high quality‐factor are crucial for achieving outstanding sensing performance in photonic biosensors. However, strong optical field confinement and high light–biomolecule interactions on photonic surfaces are usually contradictory and challenging to satisfy simultaneously. Here, a distinctive configuration for addressing this issue is reported: embedding a nanophotonic metasurface inside a micro vertical cavity as a meta‐channel (metacavity) biosensor. The analyte solution serves as the cavity medium, thereby maximizing the light–analyte interaction. Simulation validation is conducted to optimize the metacavity with high structural robustness and remarkable optical and sensing properties. Large‐scale low‐cost metacavity biosensors are realized by combining anodic aluminum oxide template technique and wafer bonding. Experimentally, the metacavity biosensor demonstrates a notable quality‐factor (maximum 4140) and high bulk refractometric sensitivity (450 nm RIU−1), resulting in an unprecedented figure‐of‐merit (1670 RIU−1). Moreover, the metacavity biosensor achieves high surface sensitivity, together with a detection‐limit of 119 viral copies mL−1 for label‐free severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pseudovirus sensing, revealing remarkable performance in both bulk and surface sensing. |
| format | Article |
| id | doaj-art-1e261dbd3f7e442b91383bd5997c422f |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-1e261dbd3f7e442b91383bd5997c422f2025-01-29T09:50:18ZengWileyAdvanced Science2198-38442025-01-01124n/an/a10.1002/advs.202410125High Quality–Factor All–Dielectric Metacavity for Label–Free BiosensingYuqiao Zheng0Jiacheng Sun1Yaqing Ma2Hongyong Zhang3Zhen Cui4Giannis G. Paschos5Xixi Song6Ying Tao7Pavlos Savvidis8Wei Kong9Liaoyong Wen10Sumin Bian11Mohamad Sawan12Zhejiang University Hangzhou Zhejiang 310058 ChinaKey Laboratory of 3D Micro/Nano Fabrication and Characterization of Zhejiang School of Engineering Westlake University Hangzhou Zhejiang 310030 ChinaAdvanced Solid‐state Semiconductor Lab School of Engineering Westlake University Hangzhou Zhejiang 310024 ChinaCenBRAIN Neurotech Center of Excellence School of Engineering Westlake University Hangzhou Zhejiang 310030 ChinaKey Laboratory for Quantum Materials of Zhejiang Province Department of Physics School of Science Westlake University Hangzhou Zhejiang 310030 ChinaKey Laboratory for Quantum Materials of Zhejiang Province Department of Physics School of Science Westlake University Hangzhou Zhejiang 310030 ChinaCenBRAIN Neurotech Center of Excellence School of Engineering Westlake University Hangzhou Zhejiang 310030 ChinaCenBRAIN Neurotech Center of Excellence School of Engineering Westlake University Hangzhou Zhejiang 310030 ChinaKey Laboratory for Quantum Materials of Zhejiang Province Department of Physics School of Science Westlake University Hangzhou Zhejiang 310030 ChinaAdvanced Solid‐state Semiconductor Lab School of Engineering Westlake University Hangzhou Zhejiang 310024 ChinaKey Laboratory of 3D Micro/Nano Fabrication and Characterization of Zhejiang School of Engineering Westlake University Hangzhou Zhejiang 310030 ChinaCenBRAIN Neurotech Center of Excellence School of Engineering Westlake University Hangzhou Zhejiang 310030 ChinaCenBRAIN Neurotech Center of Excellence School of Engineering Westlake University Hangzhou Zhejiang 310030 ChinaAbstract High sensitivity and high quality‐factor are crucial for achieving outstanding sensing performance in photonic biosensors. However, strong optical field confinement and high light–biomolecule interactions on photonic surfaces are usually contradictory and challenging to satisfy simultaneously. Here, a distinctive configuration for addressing this issue is reported: embedding a nanophotonic metasurface inside a micro vertical cavity as a meta‐channel (metacavity) biosensor. The analyte solution serves as the cavity medium, thereby maximizing the light–analyte interaction. Simulation validation is conducted to optimize the metacavity with high structural robustness and remarkable optical and sensing properties. Large‐scale low‐cost metacavity biosensors are realized by combining anodic aluminum oxide template technique and wafer bonding. Experimentally, the metacavity biosensor demonstrates a notable quality‐factor (maximum 4140) and high bulk refractometric sensitivity (450 nm RIU−1), resulting in an unprecedented figure‐of‐merit (1670 RIU−1). Moreover, the metacavity biosensor achieves high surface sensitivity, together with a detection‐limit of 119 viral copies mL−1 for label‐free severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pseudovirus sensing, revealing remarkable performance in both bulk and surface sensing.https://doi.org/10.1002/advs.202410125biosensorhigh quality‐factormetasurfacemicrocavityvirus detection |
| spellingShingle | Yuqiao Zheng Jiacheng Sun Yaqing Ma Hongyong Zhang Zhen Cui Giannis G. Paschos Xixi Song Ying Tao Pavlos Savvidis Wei Kong Liaoyong Wen Sumin Bian Mohamad Sawan High Quality–Factor All–Dielectric Metacavity for Label–Free Biosensing Advanced Science biosensor high quality‐factor metasurface microcavity virus detection |
| title | High Quality–Factor All–Dielectric Metacavity for Label–Free Biosensing |
| title_full | High Quality–Factor All–Dielectric Metacavity for Label–Free Biosensing |
| title_fullStr | High Quality–Factor All–Dielectric Metacavity for Label–Free Biosensing |
| title_full_unstemmed | High Quality–Factor All–Dielectric Metacavity for Label–Free Biosensing |
| title_short | High Quality–Factor All–Dielectric Metacavity for Label–Free Biosensing |
| title_sort | high quality factor all dielectric metacavity for label free biosensing |
| topic | biosensor high quality‐factor metasurface microcavity virus detection |
| url | https://doi.org/10.1002/advs.202410125 |
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