The Role of Autophagy and Related MicroRNAs in Inflammatory Bowel Disease
Accumulating evidence demonstrates that microRNA- (miR-) mediated posttranscriptional regulation plays an important role in autophagy in inflammatory bowel disease (IBD), a disease that is difficult to manage clinically because of the associated chronic recurrent nonspecific inflammation. Research i...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2018/7565076 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832567357553246208 |
|---|---|
| author | Shiyuan Wang Yan Huang Cili Zhou Huangan Wu Jimeng Zhao Luyi Wu Min Zhao Fang Zhang Huirong Liu |
| author_facet | Shiyuan Wang Yan Huang Cili Zhou Huangan Wu Jimeng Zhao Luyi Wu Min Zhao Fang Zhang Huirong Liu |
| author_sort | Shiyuan Wang |
| collection | DOAJ |
| description | Accumulating evidence demonstrates that microRNA- (miR-) mediated posttranscriptional regulation plays an important role in autophagy in inflammatory bowel disease (IBD), a disease that is difficult to manage clinically because of the associated chronic recurrent nonspecific inflammation. Research indicates that microRNAs regulate autophagy via different pathways, playing an important role in the IBD process and providing a new perspective for IBD research. Related studies have shown that miR-142-3p, miR-320, miR-192, and miR-122 target NOD2, an IBD-relevant autophagy gene, to modulate autophagy in IBD. miR-142-3p, miR-93, miR-106B, miR-30C, miR-130a, miR-346, and miR-20a regulate autophagy by targeting ATG16L1 through several different pathways. miR-196 can downregulate IRGM and suppress autophagy by inhibiting the accumulation of LC3II. During the endoplasmic reticulum stress response, miR-665, miR-375, and miR-150 modulate autophagy by regulating the unfolded protein response, which may play an important role in IBD intestinal fibrosis. Regarding autophagy-related pathways, miR-146b, miR-221-5p, miR-132, miR-223, miR-155, and miR-21 regulate NF-κB or mTOR signaling to induce or inhibit autophagy in intestinal cells by releasing anti- or proinflammatory factors, respectively. |
| format | Article |
| id | doaj-art-1e22fb158a3d4eb0b4216a4bb6c15a73 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-1e22fb158a3d4eb0b4216a4bb6c15a732025-02-03T01:01:38ZengWileyGastroenterology Research and Practice1687-61211687-630X2018-01-01201810.1155/2018/75650767565076The Role of Autophagy and Related MicroRNAs in Inflammatory Bowel DiseaseShiyuan Wang0Yan Huang1Cili Zhou2Huangan Wu3Jimeng Zhao4Luyi Wu5Min Zhao6Fang Zhang7Huirong Liu8Key Laboratory of Acupuncture-Moxibustion and Immunology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaShanghai Research Institute of Acupuncture and Meridian, Shanghai 200030, ChinaShanghai Research Institute of Acupuncture and Meridian, Shanghai 200030, ChinaShanghai Research Institute of Acupuncture and Meridian, Shanghai 200030, ChinaShanghai Research Institute of Acupuncture and Meridian, Shanghai 200030, ChinaKey Laboratory of Acupuncture-Moxibustion and Immunology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaKey Laboratory of Acupuncture-Moxibustion and Immunology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaShanghai Research Institute of Acupuncture and Meridian, Shanghai 200030, ChinaShanghai Research Institute of Acupuncture and Meridian, Shanghai 200030, ChinaAccumulating evidence demonstrates that microRNA- (miR-) mediated posttranscriptional regulation plays an important role in autophagy in inflammatory bowel disease (IBD), a disease that is difficult to manage clinically because of the associated chronic recurrent nonspecific inflammation. Research indicates that microRNAs regulate autophagy via different pathways, playing an important role in the IBD process and providing a new perspective for IBD research. Related studies have shown that miR-142-3p, miR-320, miR-192, and miR-122 target NOD2, an IBD-relevant autophagy gene, to modulate autophagy in IBD. miR-142-3p, miR-93, miR-106B, miR-30C, miR-130a, miR-346, and miR-20a regulate autophagy by targeting ATG16L1 through several different pathways. miR-196 can downregulate IRGM and suppress autophagy by inhibiting the accumulation of LC3II. During the endoplasmic reticulum stress response, miR-665, miR-375, and miR-150 modulate autophagy by regulating the unfolded protein response, which may play an important role in IBD intestinal fibrosis. Regarding autophagy-related pathways, miR-146b, miR-221-5p, miR-132, miR-223, miR-155, and miR-21 regulate NF-κB or mTOR signaling to induce or inhibit autophagy in intestinal cells by releasing anti- or proinflammatory factors, respectively.http://dx.doi.org/10.1155/2018/7565076 |
| spellingShingle | Shiyuan Wang Yan Huang Cili Zhou Huangan Wu Jimeng Zhao Luyi Wu Min Zhao Fang Zhang Huirong Liu The Role of Autophagy and Related MicroRNAs in Inflammatory Bowel Disease Gastroenterology Research and Practice |
| title | The Role of Autophagy and Related MicroRNAs in Inflammatory Bowel Disease |
| title_full | The Role of Autophagy and Related MicroRNAs in Inflammatory Bowel Disease |
| title_fullStr | The Role of Autophagy and Related MicroRNAs in Inflammatory Bowel Disease |
| title_full_unstemmed | The Role of Autophagy and Related MicroRNAs in Inflammatory Bowel Disease |
| title_short | The Role of Autophagy and Related MicroRNAs in Inflammatory Bowel Disease |
| title_sort | role of autophagy and related micrornas in inflammatory bowel disease |
| url | http://dx.doi.org/10.1155/2018/7565076 |
| work_keys_str_mv | AT shiyuanwang theroleofautophagyandrelatedmicrornasininflammatoryboweldisease AT yanhuang theroleofautophagyandrelatedmicrornasininflammatoryboweldisease AT cilizhou theroleofautophagyandrelatedmicrornasininflammatoryboweldisease AT huanganwu theroleofautophagyandrelatedmicrornasininflammatoryboweldisease AT jimengzhao theroleofautophagyandrelatedmicrornasininflammatoryboweldisease AT luyiwu theroleofautophagyandrelatedmicrornasininflammatoryboweldisease AT minzhao theroleofautophagyandrelatedmicrornasininflammatoryboweldisease AT fangzhang theroleofautophagyandrelatedmicrornasininflammatoryboweldisease AT huirongliu theroleofautophagyandrelatedmicrornasininflammatoryboweldisease AT shiyuanwang roleofautophagyandrelatedmicrornasininflammatoryboweldisease AT yanhuang roleofautophagyandrelatedmicrornasininflammatoryboweldisease AT cilizhou roleofautophagyandrelatedmicrornasininflammatoryboweldisease AT huanganwu roleofautophagyandrelatedmicrornasininflammatoryboweldisease AT jimengzhao roleofautophagyandrelatedmicrornasininflammatoryboweldisease AT luyiwu roleofautophagyandrelatedmicrornasininflammatoryboweldisease AT minzhao roleofautophagyandrelatedmicrornasininflammatoryboweldisease AT fangzhang roleofautophagyandrelatedmicrornasininflammatoryboweldisease AT huirongliu roleofautophagyandrelatedmicrornasininflammatoryboweldisease |