Metal‐based nanomaterials and nanocomposites as promising frontier in cancer chemotherapy
Abstract Cancer is a disease associated with complex pathology and one of the most prevalent and leading reasons for mortality in the world. Current chemotherapy has challenges with cytotoxicity, selectivity, multidrug resistance, and the formation of stemlike cells. Nanomaterials (NMs) have unique...
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| Format: | Article |
| Language: | English |
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Wiley
2023-04-01
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| Series: | MedComm |
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| Online Access: | https://doi.org/10.1002/mco2.253 |
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| author | Sunil Kumar Monu Kumar Shukla Abhishek Kumar Sharma Gururaj K. Jayaprakash Rajiv K. Tonk Dinesh K. Chellappan Sachin Kumar Singh Kamal Dua Faheem Ahmed Sanjib Bhattacharyya Deepak Kumar |
| author_facet | Sunil Kumar Monu Kumar Shukla Abhishek Kumar Sharma Gururaj K. Jayaprakash Rajiv K. Tonk Dinesh K. Chellappan Sachin Kumar Singh Kamal Dua Faheem Ahmed Sanjib Bhattacharyya Deepak Kumar |
| author_sort | Sunil Kumar |
| collection | DOAJ |
| description | Abstract Cancer is a disease associated with complex pathology and one of the most prevalent and leading reasons for mortality in the world. Current chemotherapy has challenges with cytotoxicity, selectivity, multidrug resistance, and the formation of stemlike cells. Nanomaterials (NMs) have unique properties that make them useful for various diagnostic and therapeutic purposes in cancer research. NMs can be engineered to target cancer cells for early detection and can deliver drugs directly to cancer cells, reducing side effects and improving treatment efficacy. Several of NMs can also be used for photothermal therapy to destroy cancer cells or enhance immune response to cancer by delivering immune‐stimulating molecules to immune cells or modulating the tumor microenvironment. NMs are being modified to overcome issues, such as toxicity, lack of selectivity, increase drug capacity, and bioavailability, for a wide spectrum of cancer therapies. To improve targeted drug delivery using nano‐carriers, noteworthy research is required. Several metal‐based NMs have been studied with the expectation of finding a cure for cancer treatment. In this review, the current development and the potential of plant and metal‐based NMs with their effects on size and shape have been discussed along with their more effective usage in cancer diagnosis and treatment. |
| format | Article |
| id | doaj-art-1e15f7bd7de047ac9d505287a25b1722 |
| institution | Kabale University |
| issn | 2688-2663 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm |
| spelling | doaj-art-1e15f7bd7de047ac9d505287a25b17222025-01-24T05:36:29ZengWileyMedComm2688-26632023-04-0142n/an/a10.1002/mco2.253Metal‐based nanomaterials and nanocomposites as promising frontier in cancer chemotherapySunil Kumar0Monu Kumar Shukla1Abhishek Kumar Sharma2Gururaj K. Jayaprakash3Rajiv K. Tonk4Dinesh K. Chellappan5Sachin Kumar Singh6Kamal Dua7Faheem Ahmed8Sanjib Bhattacharyya9Deepak Kumar10Department of Pharmaceutical Chemistry School of Pharmaceutical Sciences Shoolini University Solan Himachal Pradesh IndiaDepartment of Pharmaceutical Chemistry School of Pharmaceutical Sciences Shoolini University Solan Himachal Pradesh IndiaSchool of Pharmaceutical Sciences Shoolini University Solan Himachal Pradesh IndiaDepartment of Chemistry Nitte Meenakshi Institute of Technology Bangalore Karnataka IndiaSchool of Pharmaceutical Sciences Delhi Pharmaceutical Sciences and Research University New Delhi Delhi IndiaDepartment of Life Sciences International Medical University Kuala Lumpur MalaysiaSchool of Pharmaceutical Sciences Lovely Professional University Phagwara Punjab IndiaDiscipline of Pharmacy, Graduate School of Health University of Technology Sydney Ultimo New South Wales AustraliaDepartment of Physics College of Science King Faisal University Al‐Hofuf Al‐Ahsa Saudi ArabiaInstitute of Science Nirma University Ahmedabad Gujarat IndiaDepartment of Pharmaceutical Chemistry School of Pharmaceutical Sciences Shoolini University Solan Himachal Pradesh IndiaAbstract Cancer is a disease associated with complex pathology and one of the most prevalent and leading reasons for mortality in the world. Current chemotherapy has challenges with cytotoxicity, selectivity, multidrug resistance, and the formation of stemlike cells. Nanomaterials (NMs) have unique properties that make them useful for various diagnostic and therapeutic purposes in cancer research. NMs can be engineered to target cancer cells for early detection and can deliver drugs directly to cancer cells, reducing side effects and improving treatment efficacy. Several of NMs can also be used for photothermal therapy to destroy cancer cells or enhance immune response to cancer by delivering immune‐stimulating molecules to immune cells or modulating the tumor microenvironment. NMs are being modified to overcome issues, such as toxicity, lack of selectivity, increase drug capacity, and bioavailability, for a wide spectrum of cancer therapies. To improve targeted drug delivery using nano‐carriers, noteworthy research is required. Several metal‐based NMs have been studied with the expectation of finding a cure for cancer treatment. In this review, the current development and the potential of plant and metal‐based NMs with their effects on size and shape have been discussed along with their more effective usage in cancer diagnosis and treatment.https://doi.org/10.1002/mco2.253cancerchemotherapynanocompositesnanomaterialsnanomedicine |
| spellingShingle | Sunil Kumar Monu Kumar Shukla Abhishek Kumar Sharma Gururaj K. Jayaprakash Rajiv K. Tonk Dinesh K. Chellappan Sachin Kumar Singh Kamal Dua Faheem Ahmed Sanjib Bhattacharyya Deepak Kumar Metal‐based nanomaterials and nanocomposites as promising frontier in cancer chemotherapy MedComm cancer chemotherapy nanocomposites nanomaterials nanomedicine |
| title | Metal‐based nanomaterials and nanocomposites as promising frontier in cancer chemotherapy |
| title_full | Metal‐based nanomaterials and nanocomposites as promising frontier in cancer chemotherapy |
| title_fullStr | Metal‐based nanomaterials and nanocomposites as promising frontier in cancer chemotherapy |
| title_full_unstemmed | Metal‐based nanomaterials and nanocomposites as promising frontier in cancer chemotherapy |
| title_short | Metal‐based nanomaterials and nanocomposites as promising frontier in cancer chemotherapy |
| title_sort | metal based nanomaterials and nanocomposites as promising frontier in cancer chemotherapy |
| topic | cancer chemotherapy nanocomposites nanomaterials nanomedicine |
| url | https://doi.org/10.1002/mco2.253 |
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