Salvage of Failed Local and Regional Flaps with Porcine Urinary Bladder Extracellular Matrix Aided Tissue Regeneration
Local and regional flap failure can be a major complication in head and neck surgery, which continue to be prevalent for a number of reasons including poor flap design, improper surgical technique, and poor tissue vascularity. Dealing with these failures can be quite difficult. Su...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Otolaryngology |
| Online Access: | http://dx.doi.org/10.1155/2013/917183 |
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| author | Gregory J. Kruper Zachary P. VandeGriend Ho-Sheng Lin Giancarlo F. Zuliani |
| author_facet | Gregory J. Kruper Zachary P. VandeGriend Ho-Sheng Lin Giancarlo F. Zuliani |
| author_sort | Gregory J. Kruper |
| collection | DOAJ |
| description | Local and regional flap failure can be a major complication in head and neck surgery,
which continue to be prevalent for a number of reasons including poor flap design, improper surgical technique, and poor tissue vascularity. Dealing with these failures can
be quite difficult.
Surgical debridement, flap revisions, and complex wound regimens are necessitated to
reestablish appropriate tissue coverage. Traditional use of wet to dry dressing to enable
proper wound granulation and possible closure with additional flaps or skin grafts is a
laborious process. Such treatments place great time burdens on the patient, physicians, and nurses.
Because the face and neck possess a complex three-dimensional topography,
wound dressings are inherently complex to design and change. Many patients also require postoperative
treatments such as radiation and chemotherapy to treat aggressive malignancies, and delay in
wound healing leads to a delay in adjuvant treatment. Recently, advances in regenerative medicine,
specifically xenogeneic extracellular matrix compounds, have been shown to promote tissue growth while limiting
scar tissue formation (Badylak 2004). To our knowledge, this paper is the first case series using the porcine
extracellular matrix bioscaffold (MatriStem ACell, Columbia, MD, USA) to salvage flaps with extensive wound breakdown on the face and neck. |
| format | Article |
| id | doaj-art-1e1573c1955d44999ef264c7eb29d9c4 |
| institution | Kabale University |
| issn | 2090-6765 2090-6773 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Otolaryngology |
| spelling | doaj-art-1e1573c1955d44999ef264c7eb29d9c42025-02-03T06:44:40ZengWileyCase Reports in Otolaryngology2090-67652090-67732013-01-01201310.1155/2013/917183917183Salvage of Failed Local and Regional Flaps with Porcine Urinary Bladder Extracellular Matrix Aided Tissue RegenerationGregory J. Kruper0Zachary P. VandeGriend1Ho-Sheng Lin2Giancarlo F. Zuliani3Department of Otolaryngology, Head and Neck Surgery, Wayne State University School of Medicine, 4201 St. Antoine, 5E-UHC, Detroit, MI 48201, USADepartment of Otolaryngology, Head and Neck Surgery, Wayne State University School of Medicine, 4201 St. Antoine, 5E-UHC, Detroit, MI 48201, USADepartment of Otolaryngology, Head and Neck Surgery, Wayne State University School of Medicine and Karmanos Cancer Institute, 4201 St. Antoine, 5E-UHC, Detroit, MI 48201, USADivision of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology, Head and Neck Surgery, Wayne State University School of Medicine and Karmanos Cancer Institute, 4201 St. Antoine, 5E-UHC, Detroit, MI 48201, USALocal and regional flap failure can be a major complication in head and neck surgery, which continue to be prevalent for a number of reasons including poor flap design, improper surgical technique, and poor tissue vascularity. Dealing with these failures can be quite difficult. Surgical debridement, flap revisions, and complex wound regimens are necessitated to reestablish appropriate tissue coverage. Traditional use of wet to dry dressing to enable proper wound granulation and possible closure with additional flaps or skin grafts is a laborious process. Such treatments place great time burdens on the patient, physicians, and nurses. Because the face and neck possess a complex three-dimensional topography, wound dressings are inherently complex to design and change. Many patients also require postoperative treatments such as radiation and chemotherapy to treat aggressive malignancies, and delay in wound healing leads to a delay in adjuvant treatment. Recently, advances in regenerative medicine, specifically xenogeneic extracellular matrix compounds, have been shown to promote tissue growth while limiting scar tissue formation (Badylak 2004). To our knowledge, this paper is the first case series using the porcine extracellular matrix bioscaffold (MatriStem ACell, Columbia, MD, USA) to salvage flaps with extensive wound breakdown on the face and neck.http://dx.doi.org/10.1155/2013/917183 |
| spellingShingle | Gregory J. Kruper Zachary P. VandeGriend Ho-Sheng Lin Giancarlo F. Zuliani Salvage of Failed Local and Regional Flaps with Porcine Urinary Bladder Extracellular Matrix Aided Tissue Regeneration Case Reports in Otolaryngology |
| title | Salvage of Failed Local and Regional Flaps with Porcine Urinary Bladder Extracellular Matrix Aided Tissue Regeneration |
| title_full | Salvage of Failed Local and Regional Flaps with Porcine Urinary Bladder Extracellular Matrix Aided Tissue Regeneration |
| title_fullStr | Salvage of Failed Local and Regional Flaps with Porcine Urinary Bladder Extracellular Matrix Aided Tissue Regeneration |
| title_full_unstemmed | Salvage of Failed Local and Regional Flaps with Porcine Urinary Bladder Extracellular Matrix Aided Tissue Regeneration |
| title_short | Salvage of Failed Local and Regional Flaps with Porcine Urinary Bladder Extracellular Matrix Aided Tissue Regeneration |
| title_sort | salvage of failed local and regional flaps with porcine urinary bladder extracellular matrix aided tissue regeneration |
| url | http://dx.doi.org/10.1155/2013/917183 |
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