Essential oil and furanosesquiterpenes from myrrh oleo-gum resin: a breakthrough in mosquito vector management
Abstract Mosquitoes (Diptera: Culicidae) are vectors of various pathogens of public health concern and replacing conventional insecticides remains a challenge. In this regard, natural products represent valuable sources of potential insecticidal compounds, thus increasingly attracting research inter...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-01-01
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| Series: | Natural Products and Bioprospecting |
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| Online Access: | https://doi.org/10.1007/s13659-024-00492-6 |
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| author | Eleonora Spinozzi Marta Ferrati Cecilia Baldassarri Paolo Rossi Guido Favia Giorgio Cameli Giovanni Benelli Angelo Canale Livia De Fazi Roman Pavela Luana Quassinti Cristiano Giordani Fabrizio Araniti Loredana Cappellacci Riccardo Petrelli Filippo Maggi |
| author_facet | Eleonora Spinozzi Marta Ferrati Cecilia Baldassarri Paolo Rossi Guido Favia Giorgio Cameli Giovanni Benelli Angelo Canale Livia De Fazi Roman Pavela Luana Quassinti Cristiano Giordani Fabrizio Araniti Loredana Cappellacci Riccardo Petrelli Filippo Maggi |
| author_sort | Eleonora Spinozzi |
| collection | DOAJ |
| description | Abstract Mosquitoes (Diptera: Culicidae) are vectors of various pathogens of public health concern and replacing conventional insecticides remains a challenge. In this regard, natural products represent valuable sources of potential insecticidal compounds, thus increasingly attracting research interest. Commiphora myrrha (T.Nees) Engl. (Burseraceae) is a medicinal plant whose oleo-gum resin is used in food, cosmetics, fragrances, and pharmaceuticals. Herein, the larvicidal potential of its essential oil (EO) was assessed on four mosquito species (Aedes albopictus Skuse, Aedes aegypti L., Anopheles gambiae Giles and Anopheles stephensi Liston), with LC50 values ranging from 4.42 to 16.80 μg/mL. The bio-guided EO fractionation identified furanosesquiterpenes as the main larvicidal compounds. A GC–MS-driven untargeted metabolomic analysis revealed 32 affected metabolic pathways in treated larvae. The EO non-target toxicity on Daphnia magna Straus (LC50 = 4.51 μL/L) and its cytotoxicity on a human kidney cell line (HEK293) (IC50 of 14.38 μg/mL) were also assessed. This study shows the potential of plant products as innovative insecticidal agents and lays the groundwork for the possible exploitation of C. myrrha EO in sustainable approaches for mosquito management. Graphical Abstract |
| format | Article |
| id | doaj-art-1dffe1d89b5541b18b7fb4bcd82b9e36 |
| institution | Kabale University |
| issn | 2192-2195 2192-2209 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Natural Products and Bioprospecting |
| spelling | doaj-art-1dffe1d89b5541b18b7fb4bcd82b9e362025-01-26T12:57:49ZengSpringerOpenNatural Products and Bioprospecting2192-21952192-22092025-01-0115111710.1007/s13659-024-00492-6Essential oil and furanosesquiterpenes from myrrh oleo-gum resin: a breakthrough in mosquito vector managementEleonora Spinozzi0Marta Ferrati1Cecilia Baldassarri2Paolo Rossi3Guido Favia4Giorgio Cameli5Giovanni Benelli6Angelo Canale7Livia De Fazi8Roman Pavela9Luana Quassinti10Cristiano Giordani11Fabrizio Araniti12Loredana Cappellacci13Riccardo Petrelli14Filippo Maggi15Chemistry Interdisciplinary Project (ChIP) Research Center, School of Pharmacy, University of CamerinoChemistry Interdisciplinary Project (ChIP) Research Center, School of Pharmacy, University of CamerinoSchool of Biosciences and Veterinary Medicine, University of CamerinoSchool of Biosciences and Veterinary Medicine, University of CamerinoSchool of Biosciences and Veterinary Medicine, University of CamerinoChemistry Interdisciplinary Project (ChIP) Research Center, School of Pharmacy, University of CamerinoDepartment of Agriculture, Food and Environment, University of PisaDepartment of Agriculture, Food and Environment, University of PisaDepartment of Agriculture, Food and Environment, University of PisaCrop Research InstituteSchool of Pharmacy, University of CamerinoInstituto de Física, Universidad de Antioquia, UdeADipartimento di Scienze Agrarie e Ambientali, Produzione, Territorio, Agroenergia, Università Statale di MilanoChemistry Interdisciplinary Project (ChIP) Research Center, School of Pharmacy, University of CamerinoChemistry Interdisciplinary Project (ChIP) Research Center, School of Pharmacy, University of CamerinoChemistry Interdisciplinary Project (ChIP) Research Center, School of Pharmacy, University of CamerinoAbstract Mosquitoes (Diptera: Culicidae) are vectors of various pathogens of public health concern and replacing conventional insecticides remains a challenge. In this regard, natural products represent valuable sources of potential insecticidal compounds, thus increasingly attracting research interest. Commiphora myrrha (T.Nees) Engl. (Burseraceae) is a medicinal plant whose oleo-gum resin is used in food, cosmetics, fragrances, and pharmaceuticals. Herein, the larvicidal potential of its essential oil (EO) was assessed on four mosquito species (Aedes albopictus Skuse, Aedes aegypti L., Anopheles gambiae Giles and Anopheles stephensi Liston), with LC50 values ranging from 4.42 to 16.80 μg/mL. The bio-guided EO fractionation identified furanosesquiterpenes as the main larvicidal compounds. A GC–MS-driven untargeted metabolomic analysis revealed 32 affected metabolic pathways in treated larvae. The EO non-target toxicity on Daphnia magna Straus (LC50 = 4.51 μL/L) and its cytotoxicity on a human kidney cell line (HEK293) (IC50 of 14.38 μg/mL) were also assessed. This study shows the potential of plant products as innovative insecticidal agents and lays the groundwork for the possible exploitation of C. myrrha EO in sustainable approaches for mosquito management. Graphical Abstracthttps://doi.org/10.1007/s13659-024-00492-6Arbovirus vectorCommiphora myrrhaAedes aegyptiAnopheles spp.Bioinsecticide |
| spellingShingle | Eleonora Spinozzi Marta Ferrati Cecilia Baldassarri Paolo Rossi Guido Favia Giorgio Cameli Giovanni Benelli Angelo Canale Livia De Fazi Roman Pavela Luana Quassinti Cristiano Giordani Fabrizio Araniti Loredana Cappellacci Riccardo Petrelli Filippo Maggi Essential oil and furanosesquiterpenes from myrrh oleo-gum resin: a breakthrough in mosquito vector management Natural Products and Bioprospecting Arbovirus vector Commiphora myrrha Aedes aegypti Anopheles spp. Bioinsecticide |
| title | Essential oil and furanosesquiterpenes from myrrh oleo-gum resin: a breakthrough in mosquito vector management |
| title_full | Essential oil and furanosesquiterpenes from myrrh oleo-gum resin: a breakthrough in mosquito vector management |
| title_fullStr | Essential oil and furanosesquiterpenes from myrrh oleo-gum resin: a breakthrough in mosquito vector management |
| title_full_unstemmed | Essential oil and furanosesquiterpenes from myrrh oleo-gum resin: a breakthrough in mosquito vector management |
| title_short | Essential oil and furanosesquiterpenes from myrrh oleo-gum resin: a breakthrough in mosquito vector management |
| title_sort | essential oil and furanosesquiterpenes from myrrh oleo gum resin a breakthrough in mosquito vector management |
| topic | Arbovirus vector Commiphora myrrha Aedes aegypti Anopheles spp. Bioinsecticide |
| url | https://doi.org/10.1007/s13659-024-00492-6 |
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