Demographics and regional trends of ischemic heart disease-related mortality in older adults in the United States, 1999-2020.

<h4>Background</h4>Ischemic heart disease (IHD) has a significant impact on public health and healthcare expenditures in the United States (US).<h4>Methods</h4>We used data from the CDC WONDER database from 1999-2020 to identify trends in the IHD-related mortality of patients...

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Main Authors: Fakhar Latif, Muhammad Moiz Nasir, Wajeeh Ur Rehman, Mohammed Hamza, Jishanth Mattumpuram, Komail Khalid Meer, Helme Silvet, Alon Yarkoni, Mouhamed Amr Sabouni, Nabil Braiteh, Keyoor Patel, Abdulqadir J Nashwan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0318073&type=printable
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Summary:<h4>Background</h4>Ischemic heart disease (IHD) has a significant impact on public health and healthcare expenditures in the United States (US).<h4>Methods</h4>We used data from the CDC WONDER database from 1999-2020 to identify trends in the IHD-related mortality of patients ≥ 75 years in the US. AAMRs per 100,000 population and APC were calculated and categorized by year, sex, race, and geographic divisions.<h4>Results</h4>Between 1999 and 2020, a total of 8,124,568 IHD-related deaths were recorded. Notable declines in AAMR were observed from 1999 to 2014 (APC: -3.86) and from 2014 to 2018 (APC: -2.55), with an overall increase from 2018 to 2020 (APC: 3.76). Older men consistently demonstrated higher AAMRs than older females, with AAMRs for both sexes decreasing steadily from 1999 to 2018 and increasing in 2020. When stratified by race/ethnicity, Whites (1931.7) had the highest AAMR, followed by Blacks (1836.5), American Indians (1510.5), Hispanics (1464.4), and Asians (1093.6). Furthermore, nonmetropolitan areas (2015.2) showed greater AAMRs than metropolitan areas (1841.8). The ≥ 85-year group consistently exhibited higher IHD-related mortality rates compared to the 75-84 years group. In comparison, the older group [≥75 years] (1873.0) consistently exhibited higher IHD-related AAMRs than the younger group [<75 years] (64.0) throughout the study, showing a significant disparity. Chronic IHD (1552.0) consistently showed the highest AAMRs throughout the study, surpassing myocardial infarction (515.6), other ischemic heart diseases (24.0), and angina pectoris (5.6).<h4>Conclusion</h4>Targeted interventions and resource allocation are crucial for areas with high IHD-related mortality. Public health policies should address demographic and geographical disparities, with further research for effective strategies.
ISSN:1932-6203