Effect of Acarbose on Long-Term Prognosis in Acute Coronary Syndromes Patients with Newly Diagnosed Impaired Glucose Tolerance
Objective. To investigate the effect of acarbose therapy on the long-term prognosis of patients with acute coronary syndromes (ACS) complicating newly diagnosed impaired glucose tolerance (IGT). Methodology. 135 patients hospitalized for ACS who had been newly diagnosed with IGT were randomly assign...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/1602083 |
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| author | Peng Yun Ai-ming Du Xue-jun Chen Jing-cheng Liu Hu Xiao |
| author_facet | Peng Yun Ai-ming Du Xue-jun Chen Jing-cheng Liu Hu Xiao |
| author_sort | Peng Yun |
| collection | DOAJ |
| description | Objective. To investigate the effect of acarbose therapy on the long-term prognosis of patients with acute coronary syndromes (ACS) complicating newly diagnosed impaired glucose tolerance (IGT). Methodology. 135 patients hospitalized for ACS who had been newly diagnosed with IGT were randomly assigned to acarbose group (150 mg/day, n=67) or control group (no acarbose, n=68). All cases in each group were given the same elementary treatment. Mean follow-up was 2.3 years. The incidence of major adverse cardiovascular event (MACE) and carotid intima-middle thickness (CIMT) were statistically analyzed. Results. During the mean follow-up of 2.3 years, the risk of recurrent MACE in acarbose group was decreased significantly compared with that in control group (26.67% versus 46.88%, P<0.05); at the same time, thickening of the CIMT was significantly slower than the control group ((1.28 ± 0.42) mm versus (1.51 ± 0.64) mm, P<0.05). Conclusions. Acarbose can effectively reduce the risk of MACE in ACS patients with newly diagnosed IGT, simultaneously retarding the progression of carotid intima-media thickness. |
| format | Article |
| id | doaj-art-1de6188a55be42eca455730b7d0e7794 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-1de6188a55be42eca455730b7d0e77942025-02-03T00:59:19ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/16020831602083Effect of Acarbose on Long-Term Prognosis in Acute Coronary Syndromes Patients with Newly Diagnosed Impaired Glucose TolerancePeng Yun0Ai-ming Du1Xue-jun Chen2Jing-cheng Liu3Hu Xiao4Department of Internal Medicine, School of Clinical Medicine, Yangtze University, Jingzhou, Hubei 434000, ChinaDepartment of Cardiology, Central Hospital of Jingzhou City, Hubei 434001, ChinaDepartment of Cardiology, Central Hospital of Jingzhou City, Hubei 434001, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei 434000, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei 434000, ChinaObjective. To investigate the effect of acarbose therapy on the long-term prognosis of patients with acute coronary syndromes (ACS) complicating newly diagnosed impaired glucose tolerance (IGT). Methodology. 135 patients hospitalized for ACS who had been newly diagnosed with IGT were randomly assigned to acarbose group (150 mg/day, n=67) or control group (no acarbose, n=68). All cases in each group were given the same elementary treatment. Mean follow-up was 2.3 years. The incidence of major adverse cardiovascular event (MACE) and carotid intima-middle thickness (CIMT) were statistically analyzed. Results. During the mean follow-up of 2.3 years, the risk of recurrent MACE in acarbose group was decreased significantly compared with that in control group (26.67% versus 46.88%, P<0.05); at the same time, thickening of the CIMT was significantly slower than the control group ((1.28 ± 0.42) mm versus (1.51 ± 0.64) mm, P<0.05). Conclusions. Acarbose can effectively reduce the risk of MACE in ACS patients with newly diagnosed IGT, simultaneously retarding the progression of carotid intima-media thickness.http://dx.doi.org/10.1155/2016/1602083 |
| spellingShingle | Peng Yun Ai-ming Du Xue-jun Chen Jing-cheng Liu Hu Xiao Effect of Acarbose on Long-Term Prognosis in Acute Coronary Syndromes Patients with Newly Diagnosed Impaired Glucose Tolerance Journal of Diabetes Research |
| title | Effect of Acarbose on Long-Term Prognosis in Acute Coronary Syndromes Patients with Newly Diagnosed Impaired Glucose Tolerance |
| title_full | Effect of Acarbose on Long-Term Prognosis in Acute Coronary Syndromes Patients with Newly Diagnosed Impaired Glucose Tolerance |
| title_fullStr | Effect of Acarbose on Long-Term Prognosis in Acute Coronary Syndromes Patients with Newly Diagnosed Impaired Glucose Tolerance |
| title_full_unstemmed | Effect of Acarbose on Long-Term Prognosis in Acute Coronary Syndromes Patients with Newly Diagnosed Impaired Glucose Tolerance |
| title_short | Effect of Acarbose on Long-Term Prognosis in Acute Coronary Syndromes Patients with Newly Diagnosed Impaired Glucose Tolerance |
| title_sort | effect of acarbose on long term prognosis in acute coronary syndromes patients with newly diagnosed impaired glucose tolerance |
| url | http://dx.doi.org/10.1155/2016/1602083 |
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