Indoleamine-2,3-dioxygenase: An important controller in maintaining mesenchymal stem cell-mediated immunomodulatory homeostasis
Mesenchymal stem cells (MSCs) have been widely used in the treatment of various autoimmune and inflammation-related diseases due to their potent immunomodulatory properties. Several studies have demonstrated that MSC-mediated immunomodulation is complex and bidirectional, with the in vivo microenvir...
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Elsevier
2025-07-01
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| Series: | Acta Pharmaceutica Sinica B |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383525002849 |
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| author | Yufei Hui Xue Jiao Li Yang Dejin Lu Yanbo Han Wen Yang Yanli Cao Yuxi Miao Shiqiang Gong Minjie Wei |
| author_facet | Yufei Hui Xue Jiao Li Yang Dejin Lu Yanbo Han Wen Yang Yanli Cao Yuxi Miao Shiqiang Gong Minjie Wei |
| author_sort | Yufei Hui |
| collection | DOAJ |
| description | Mesenchymal stem cells (MSCs) have been widely used in the treatment of various autoimmune and inflammation-related diseases due to their potent immunomodulatory properties. Several studies have demonstrated that MSC-mediated immunomodulation is complex and bidirectional, with the in vivo microenvironment influencing the direction of this modulation. Indoleamine-2,3-dioxygenase (IDO), an immunosuppressive factor, has been identified as a key “switch” in the immunomodulatory role of MSCs. In this review, we explore how IDO functions as a critical regulator of MSC immunoregulatory plasticity. We delve into the mechanisms by which changes in IDO expression affect the function of various immune cells, summarize relevant research and clinical advances regarding the role of IDO expression in MSC-based therapies for various diseases, and discuss potential therapeutic strategies that target IDO to enhance the stability of MSC therapeutic effects. This provides a theoretical foundation for optimizing MSCs as safer and more effective clinical therapeutic agents. |
| format | Article |
| id | doaj-art-1de5bb226aa14026931d912e18a21d2d |
| institution | DOAJ |
| issn | 2211-3835 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj-art-1de5bb226aa14026931d912e18a21d2d2025-08-20T02:41:32ZengElsevierActa Pharmaceutica Sinica B2211-38352025-07-011573404341810.1016/j.apsb.2025.04.022Indoleamine-2,3-dioxygenase: An important controller in maintaining mesenchymal stem cell-mediated immunomodulatory homeostasisYufei Hui0Xue Jiao1Li Yang2Dejin Lu3Yanbo Han4Wen Yang5Yanli Cao6Yuxi Miao7Shiqiang Gong8Minjie Wei9Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, ChinaDepartment of Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, ChinaDepartment of Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, ChinaDepartment of Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, China; Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaDepartment of Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, ChinaDepartment of Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, ChinaThe First Affiliated Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, China; Corresponding authors.Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, China; Corresponding authors.Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, China; Liaoning Medical Diagnosis and Treatment Center, Shenyang 110000, China; Corresponding authors.Mesenchymal stem cells (MSCs) have been widely used in the treatment of various autoimmune and inflammation-related diseases due to their potent immunomodulatory properties. Several studies have demonstrated that MSC-mediated immunomodulation is complex and bidirectional, with the in vivo microenvironment influencing the direction of this modulation. Indoleamine-2,3-dioxygenase (IDO), an immunosuppressive factor, has been identified as a key “switch” in the immunomodulatory role of MSCs. In this review, we explore how IDO functions as a critical regulator of MSC immunoregulatory plasticity. We delve into the mechanisms by which changes in IDO expression affect the function of various immune cells, summarize relevant research and clinical advances regarding the role of IDO expression in MSC-based therapies for various diseases, and discuss potential therapeutic strategies that target IDO to enhance the stability of MSC therapeutic effects. This provides a theoretical foundation for optimizing MSCs as safer and more effective clinical therapeutic agents.http://www.sciencedirect.com/science/article/pii/S2211383525002849Mesenchymal stem cells (MSCs)Indoleamine-2,3-dioxygenase (IDO)ImmunomodulatoryPlasticityInflammationTryptophan (Trp) |
| spellingShingle | Yufei Hui Xue Jiao Li Yang Dejin Lu Yanbo Han Wen Yang Yanli Cao Yuxi Miao Shiqiang Gong Minjie Wei Indoleamine-2,3-dioxygenase: An important controller in maintaining mesenchymal stem cell-mediated immunomodulatory homeostasis Acta Pharmaceutica Sinica B Mesenchymal stem cells (MSCs) Indoleamine-2,3-dioxygenase (IDO) Immunomodulatory Plasticity Inflammation Tryptophan (Trp) |
| title | Indoleamine-2,3-dioxygenase: An important controller in maintaining mesenchymal stem cell-mediated immunomodulatory homeostasis |
| title_full | Indoleamine-2,3-dioxygenase: An important controller in maintaining mesenchymal stem cell-mediated immunomodulatory homeostasis |
| title_fullStr | Indoleamine-2,3-dioxygenase: An important controller in maintaining mesenchymal stem cell-mediated immunomodulatory homeostasis |
| title_full_unstemmed | Indoleamine-2,3-dioxygenase: An important controller in maintaining mesenchymal stem cell-mediated immunomodulatory homeostasis |
| title_short | Indoleamine-2,3-dioxygenase: An important controller in maintaining mesenchymal stem cell-mediated immunomodulatory homeostasis |
| title_sort | indoleamine 2 3 dioxygenase an important controller in maintaining mesenchymal stem cell mediated immunomodulatory homeostasis |
| topic | Mesenchymal stem cells (MSCs) Indoleamine-2,3-dioxygenase (IDO) Immunomodulatory Plasticity Inflammation Tryptophan (Trp) |
| url | http://www.sciencedirect.com/science/article/pii/S2211383525002849 |
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