Crosstalk between Innate Lymphoid Cells and Other Immune Cells in the Tumor Microenvironment
Our knowledge and understanding of the tumor microenvironment (TME) have been recently expanded with the recognition of the important role of innate lymphoid cells (ILC). Three different groups of ILC have been described based on their ability to produce cytokines that mediate the interactions betwe...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/7803091 |
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| _version_ | 1832560469608497152 |
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| author | Fabian Flores-Borja Sheeba Irshad Peter Gordon Felix Wong Ibrahim Sheriff Andrew Tutt Tony Ng |
| author_facet | Fabian Flores-Borja Sheeba Irshad Peter Gordon Felix Wong Ibrahim Sheriff Andrew Tutt Tony Ng |
| author_sort | Fabian Flores-Borja |
| collection | DOAJ |
| description | Our knowledge and understanding of the tumor microenvironment (TME) have been recently expanded with the recognition of the important role of innate lymphoid cells (ILC). Three different groups of ILC have been described based on their ability to produce cytokines that mediate the interactions between innate and adaptive immune cells in a variety of immune responses in infection, allergy, and autoimmunity. However, recent evidence from experimental models and clinical studies has demonstrated that ILC contribute to the mechanisms that generate suppressive or tolerant environments that allow tumor regression or progression. Defining the complex network of interactions and crosstalk of ILC with other immune cells and understanding the specific contributions of each type of ILC leading to tumor development will allow the manipulation of their function and will be important to develop new interventions and therapeutic strategies. |
| format | Article |
| id | doaj-art-1de2fd39c6f248f990b2629dd3c53a46 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-1de2fd39c6f248f990b2629dd3c53a462025-02-03T01:27:26ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/78030917803091Crosstalk between Innate Lymphoid Cells and Other Immune Cells in the Tumor MicroenvironmentFabian Flores-Borja0Sheeba Irshad1Peter Gordon2Felix Wong3Ibrahim Sheriff4Andrew Tutt5Tony Ng6Breast Cancer Now Research Unit, Division of Cancer Studies, Guy’s Hospital, King’s College London School of Medicine, London SE1 9RT, UKBreast Cancer Now Research Unit, Division of Cancer Studies, Guy’s Hospital, King’s College London School of Medicine, London SE1 9RT, UKBreast Cancer Now Research Unit, Division of Cancer Studies, Guy’s Hospital, King’s College London School of Medicine, London SE1 9RT, UKRichard Dimbleby Department of Cancer Research, Randall Division & Division of Cancer Studies, King’s College London, Guy’s Medical School Campus, London SE1 1ULK, UKRichard Dimbleby Department of Cancer Research, Randall Division & Division of Cancer Studies, King’s College London, Guy’s Medical School Campus, London SE1 1ULK, UKBreast Cancer Now Research Unit, Division of Cancer Studies, Guy’s Hospital, King’s College London School of Medicine, London SE1 9RT, UKBreast Cancer Now Research Unit, Division of Cancer Studies, Guy’s Hospital, King’s College London School of Medicine, London SE1 9RT, UKOur knowledge and understanding of the tumor microenvironment (TME) have been recently expanded with the recognition of the important role of innate lymphoid cells (ILC). Three different groups of ILC have been described based on their ability to produce cytokines that mediate the interactions between innate and adaptive immune cells in a variety of immune responses in infection, allergy, and autoimmunity. However, recent evidence from experimental models and clinical studies has demonstrated that ILC contribute to the mechanisms that generate suppressive or tolerant environments that allow tumor regression or progression. Defining the complex network of interactions and crosstalk of ILC with other immune cells and understanding the specific contributions of each type of ILC leading to tumor development will allow the manipulation of their function and will be important to develop new interventions and therapeutic strategies.http://dx.doi.org/10.1155/2016/7803091 |
| spellingShingle | Fabian Flores-Borja Sheeba Irshad Peter Gordon Felix Wong Ibrahim Sheriff Andrew Tutt Tony Ng Crosstalk between Innate Lymphoid Cells and Other Immune Cells in the Tumor Microenvironment Journal of Immunology Research |
| title | Crosstalk between Innate Lymphoid Cells and Other Immune Cells in the Tumor Microenvironment |
| title_full | Crosstalk between Innate Lymphoid Cells and Other Immune Cells in the Tumor Microenvironment |
| title_fullStr | Crosstalk between Innate Lymphoid Cells and Other Immune Cells in the Tumor Microenvironment |
| title_full_unstemmed | Crosstalk between Innate Lymphoid Cells and Other Immune Cells in the Tumor Microenvironment |
| title_short | Crosstalk between Innate Lymphoid Cells and Other Immune Cells in the Tumor Microenvironment |
| title_sort | crosstalk between innate lymphoid cells and other immune cells in the tumor microenvironment |
| url | http://dx.doi.org/10.1155/2016/7803091 |
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