Developing a Versatile Arsenal: Novel Antimicrobials as Offensive Tools Against Pathogenic Bacteria
The pervasive and often indiscriminate use of antibiotics has accelerated the emergence of drug-resistant bacterial strains, thus presenting an acute threat to global public health. Despite a growing acknowledgment of the severity of this crisis, the current suite of strategies to mitigate antimicro...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Microorganisms |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2607/13/1/172 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832587835134181376 |
|---|---|
| author | Junze Ma Zheng Lu |
| author_facet | Junze Ma Zheng Lu |
| author_sort | Junze Ma |
| collection | DOAJ |
| description | The pervasive and often indiscriminate use of antibiotics has accelerated the emergence of drug-resistant bacterial strains, thus presenting an acute threat to global public health. Despite a growing acknowledgment of the severity of this crisis, the current suite of strategies to mitigate antimicrobial resistance remains markedly inadequate. This paper asserts the paramount need for the swift development of groundbreaking antimicrobial strategies and provides a comprehensive review of an array of innovative techniques currently under scrutiny. Among these, nano-antimicrobials, antimicrobials derived from ribosomal proteins, CRISPR/Cas-based systems, agents that undermine bacterial bioenergetics, and antimicrobial polysaccharides hold particular promise. This analysis gives special attention to CRISPR/Cas-based antimicrobials, scrutinizing their underlying mechanisms, exploring their potential applications, delineating their distinct advantages, and noting their likely limitations. Furthermore, we extend our exploration by proposing theoretical advancements in antimicrobial technology and evaluating feasible methods for the effective delivery of these agents. This includes leveraging these advances for broader biomedical applications, potentially revolutionizing how we confront bacterial pathogens in the future, and laying a foundation for extended research in multimodal therapeutic strategies. |
| format | Article |
| id | doaj-art-1dc80bbfcc9a4618b52d5436bd062c9e |
| institution | Kabale University |
| issn | 2076-2607 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj-art-1dc80bbfcc9a4618b52d5436bd062c9e2025-01-24T13:42:55ZengMDPI AGMicroorganisms2076-26072025-01-0113117210.3390/microorganisms13010172Developing a Versatile Arsenal: Novel Antimicrobials as Offensive Tools Against Pathogenic BacteriaJunze Ma0Zheng Lu1Guangdong Provincial Key Laboratory of Marine Biotechnology, Department of Biology, Institute of Marine Sciences, Shantou University, Shantou 515063, ChinaHainan Province Key Laboratory of One Health, School of Life and Health Sciences, Collaborative Innovation Center of One Health, Hainan University, Haikou 570228, ChinaThe pervasive and often indiscriminate use of antibiotics has accelerated the emergence of drug-resistant bacterial strains, thus presenting an acute threat to global public health. Despite a growing acknowledgment of the severity of this crisis, the current suite of strategies to mitigate antimicrobial resistance remains markedly inadequate. This paper asserts the paramount need for the swift development of groundbreaking antimicrobial strategies and provides a comprehensive review of an array of innovative techniques currently under scrutiny. Among these, nano-antimicrobials, antimicrobials derived from ribosomal proteins, CRISPR/Cas-based systems, agents that undermine bacterial bioenergetics, and antimicrobial polysaccharides hold particular promise. This analysis gives special attention to CRISPR/Cas-based antimicrobials, scrutinizing their underlying mechanisms, exploring their potential applications, delineating their distinct advantages, and noting their likely limitations. Furthermore, we extend our exploration by proposing theoretical advancements in antimicrobial technology and evaluating feasible methods for the effective delivery of these agents. This includes leveraging these advances for broader biomedical applications, potentially revolutionizing how we confront bacterial pathogens in the future, and laying a foundation for extended research in multimodal therapeutic strategies.https://www.mdpi.com/2076-2607/13/1/172CRISPR/Casantimicrobial resistancenano-antimicrobialsantimicrobial polysaccharides |
| spellingShingle | Junze Ma Zheng Lu Developing a Versatile Arsenal: Novel Antimicrobials as Offensive Tools Against Pathogenic Bacteria Microorganisms CRISPR/Cas antimicrobial resistance nano-antimicrobials antimicrobial polysaccharides |
| title | Developing a Versatile Arsenal: Novel Antimicrobials as Offensive Tools Against Pathogenic Bacteria |
| title_full | Developing a Versatile Arsenal: Novel Antimicrobials as Offensive Tools Against Pathogenic Bacteria |
| title_fullStr | Developing a Versatile Arsenal: Novel Antimicrobials as Offensive Tools Against Pathogenic Bacteria |
| title_full_unstemmed | Developing a Versatile Arsenal: Novel Antimicrobials as Offensive Tools Against Pathogenic Bacteria |
| title_short | Developing a Versatile Arsenal: Novel Antimicrobials as Offensive Tools Against Pathogenic Bacteria |
| title_sort | developing a versatile arsenal novel antimicrobials as offensive tools against pathogenic bacteria |
| topic | CRISPR/Cas antimicrobial resistance nano-antimicrobials antimicrobial polysaccharides |
| url | https://www.mdpi.com/2076-2607/13/1/172 |
| work_keys_str_mv | AT junzema developingaversatilearsenalnovelantimicrobialsasoffensivetoolsagainstpathogenicbacteria AT zhenglu developingaversatilearsenalnovelantimicrobialsasoffensivetoolsagainstpathogenicbacteria |