Maternal History and Uterine Artery Doppler in the Assessment of Risk for Development of Early- and Late-Onset Preeclampsia and Intrauterine Growth Restriction
Objective. To examine the value of one-step uterine artery Doppler at 20 weeks of gestation in the prediction pre-eclampsia (PE) and/or intrauterine growth restriction (IUGR). Methods. A prospective multicentre study that included all women with singleton pregnancies at 19–22 weeks of gestation (w)...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2009/275613 |
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| author | Elisa Llurba Elena Carreras Eduard Gratacós Miquel Juan Judith Astor Angels Vives Eduard Hermosilla Ines Calero Pilar Millán Bárbara García-Valdecasas Lluís Cabero |
| author_facet | Elisa Llurba Elena Carreras Eduard Gratacós Miquel Juan Judith Astor Angels Vives Eduard Hermosilla Ines Calero Pilar Millán Bárbara García-Valdecasas Lluís Cabero |
| author_sort | Elisa Llurba |
| collection | DOAJ |
| description | Objective. To examine the value of one-step uterine artery Doppler at 20 weeks of gestation in the prediction pre-eclampsia (PE) and/or intrauterine growth restriction (IUGR).
Methods. A prospective multicentre study that included all women with singleton pregnancies at 19–22 weeks of gestation (w). The mean pulsatility index (mPI) of both uterine arteries was calculated. Receiver-operating characteristics curves (ROC) were drawn to compare uterine artery Doppler and maternal risk factors for the prediction of early-onset PE and/or IUGR (before 32 w) and late-onset PE and/or IUGR.
Results. 6,586 women were included in the study. Complete outcome data was recorded for 6,035 of these women (91.6%). PE developed in 75 (1.2%) and IUGR in 69 (1.1%) cases. Uterine Doppler mPI was 0.99 and the 90th centile was 1.40. For 10% false-positive rate, uterine Doppler mPI identified 70.6% of pregnancies that subsequently developed early-onset PE and 73.3% of pregnancies that developed early-onset IUGR. The test had a lower detection rate for the late-onset forms of the disease (23.5% for PE and 30% for IUGR). Maternal history has a low sensitivity in the detection of early-onset cases, although it is better at detecting late-onset PE.
Conclusion. Uterine artery Doppler and maternal risk factors seem to select two different populations - early and late-onset PE which might suggest a different pathogenesis. |
| format | Article |
| id | doaj-art-1dc7212eea194e6c9d4379a3cf5a81b2 |
| institution | Kabale University |
| issn | 1687-9589 1687-9597 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Obstetrics and Gynecology International |
| spelling | doaj-art-1dc7212eea194e6c9d4379a3cf5a81b22025-02-03T05:52:06ZengWileyObstetrics and Gynecology International1687-95891687-95972009-01-01200910.1155/2009/275613275613Maternal History and Uterine Artery Doppler in the Assessment of Risk for Development of Early- and Late-Onset Preeclampsia and Intrauterine Growth RestrictionElisa Llurba0Elena Carreras1Eduard Gratacós2Miquel Juan3Judith Astor4Angels Vives5Eduard Hermosilla6Ines Calero7Pilar Millán8Bárbara García-Valdecasas9Lluís Cabero10Department of Obstetrics, Fetal Medicine Unit, Vall d'Hebron Hospital, Universitat Autònoma de Barcelona, 08035-Barcelona, SpainDepartment of Obstetrics, Fetal Medicine Unit, Vall d'Hebron Hospital, Universitat Autònoma de Barcelona, 08035-Barcelona, SpainDepartment of Obstetrics, Fetal Medicine Unit, Vall d'Hebron Hospital, Universitat Autònoma de Barcelona, 08035-Barcelona, SpainDepartment of Obstetrics, Son Llatze Hospital, Mallorca, SpainDepartment of Obstetrics, Granoller Hospital, Barcelona, SpainDepartment of Obstetrics, Terrassa Hospital, Barcelona, SpainDepartment of Stadistics, Vall d'Hebron Hospital, Universitat Autònoma de Barcelona, 08035-Barcelona, SpainDepartment of Obstetrics, Fetal Medicine Unit, Vall d'Hebron Hospital, Universitat Autònoma de Barcelona, 08035-Barcelona, SpainDepartment of Obstetrics, Fetal Medicine Unit, Vall d'Hebron Hospital, Universitat Autònoma de Barcelona, 08035-Barcelona, SpainDepartment of Obstetrics, Fetal Medicine Unit, Vall d'Hebron Hospital, Universitat Autònoma de Barcelona, 08035-Barcelona, SpainDepartment of Obstetrics, Fetal Medicine Unit, Vall d'Hebron Hospital, Universitat Autònoma de Barcelona, 08035-Barcelona, SpainObjective. To examine the value of one-step uterine artery Doppler at 20 weeks of gestation in the prediction pre-eclampsia (PE) and/or intrauterine growth restriction (IUGR). Methods. A prospective multicentre study that included all women with singleton pregnancies at 19–22 weeks of gestation (w). The mean pulsatility index (mPI) of both uterine arteries was calculated. Receiver-operating characteristics curves (ROC) were drawn to compare uterine artery Doppler and maternal risk factors for the prediction of early-onset PE and/or IUGR (before 32 w) and late-onset PE and/or IUGR. Results. 6,586 women were included in the study. Complete outcome data was recorded for 6,035 of these women (91.6%). PE developed in 75 (1.2%) and IUGR in 69 (1.1%) cases. Uterine Doppler mPI was 0.99 and the 90th centile was 1.40. For 10% false-positive rate, uterine Doppler mPI identified 70.6% of pregnancies that subsequently developed early-onset PE and 73.3% of pregnancies that developed early-onset IUGR. The test had a lower detection rate for the late-onset forms of the disease (23.5% for PE and 30% for IUGR). Maternal history has a low sensitivity in the detection of early-onset cases, although it is better at detecting late-onset PE. Conclusion. Uterine artery Doppler and maternal risk factors seem to select two different populations - early and late-onset PE which might suggest a different pathogenesis.http://dx.doi.org/10.1155/2009/275613 |
| spellingShingle | Elisa Llurba Elena Carreras Eduard Gratacós Miquel Juan Judith Astor Angels Vives Eduard Hermosilla Ines Calero Pilar Millán Bárbara García-Valdecasas Lluís Cabero Maternal History and Uterine Artery Doppler in the Assessment of Risk for Development of Early- and Late-Onset Preeclampsia and Intrauterine Growth Restriction Obstetrics and Gynecology International |
| title | Maternal History and Uterine Artery Doppler in the Assessment of Risk for Development of Early- and Late-Onset Preeclampsia and Intrauterine Growth Restriction |
| title_full | Maternal History and Uterine Artery Doppler in the Assessment of Risk for Development of Early- and Late-Onset Preeclampsia and Intrauterine Growth Restriction |
| title_fullStr | Maternal History and Uterine Artery Doppler in the Assessment of Risk for Development of Early- and Late-Onset Preeclampsia and Intrauterine Growth Restriction |
| title_full_unstemmed | Maternal History and Uterine Artery Doppler in the Assessment of Risk for Development of Early- and Late-Onset Preeclampsia and Intrauterine Growth Restriction |
| title_short | Maternal History and Uterine Artery Doppler in the Assessment of Risk for Development of Early- and Late-Onset Preeclampsia and Intrauterine Growth Restriction |
| title_sort | maternal history and uterine artery doppler in the assessment of risk for development of early and late onset preeclampsia and intrauterine growth restriction |
| url | http://dx.doi.org/10.1155/2009/275613 |
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