Intracellular Shuttle: The Lactate Aerobic Metabolism
Lactate is a highly dynamic metabolite that can be used as a fuel by several cells of the human body, particularly during physical exercise. Traditionally, it has been believed that the first step of lactate oxidation occurs in cytosol; however, this idea was recently challenged. A new hypothesis ha...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/420984 |
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| author | Rogério Santos de Oliveira Cruz Rafael Alves de Aguiar Tiago Turnes Rafael Penteado Dos Santos Mariana Fernandes Mendes de Oliveira Fabrizio Caputo |
| author_facet | Rogério Santos de Oliveira Cruz Rafael Alves de Aguiar Tiago Turnes Rafael Penteado Dos Santos Mariana Fernandes Mendes de Oliveira Fabrizio Caputo |
| author_sort | Rogério Santos de Oliveira Cruz |
| collection | DOAJ |
| description | Lactate is a highly dynamic metabolite that can be used as a fuel by several cells of the human body, particularly during physical exercise. Traditionally, it has been believed that the first step of lactate oxidation occurs in cytosol; however, this idea was recently challenged. A new hypothesis has been presented based on the fact that lactate-to-pyruvate conversion cannot occur in cytosol, because the LDH enzyme characteristics and cytosolic environment do not allow the reaction in this way. Instead, the Intracellular Lactate Shuttle hypothesis states that lactate first enters in mitochondria and only then is metabolized. In several tissues of the human body this idea is well accepted but is quite resistant in skeletal muscle. In this paper, we will present not only the studies which are protagonists in this discussion, but the potential mechanism by which this oxidation occurs and also a link between lactate and mitochondrial proliferation. This new perspective brings some implications and comes to change our understanding of the interaction between the energy systems, because the product of one serves as a substrate for the other. |
| format | Article |
| id | doaj-art-1db636396da24612946c4f2de507cedf |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-1db636396da24612946c4f2de507cedf2025-02-03T01:30:19ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/420984420984Intracellular Shuttle: The Lactate Aerobic MetabolismRogério Santos de Oliveira Cruz0Rafael Alves de Aguiar1Tiago Turnes2Rafael Penteado Dos Santos3Mariana Fernandes Mendes de Oliveira4Fabrizio Caputo5Human Performance Research Group, Center of Health and Sport Sciences, Santa Catarina State University, 88080-350 Florianópolis, SC, BrazilHuman Performance Research Group, Center of Health and Sport Sciences, Santa Catarina State University, 88080-350 Florianópolis, SC, BrazilHuman Performance Research Group, Center of Health and Sport Sciences, Santa Catarina State University, 88080-350 Florianópolis, SC, BrazilHuman Performance Research Group, Center of Health and Sport Sciences, Santa Catarina State University, 88080-350 Florianópolis, SC, BrazilHuman Performance Research Group, Center of Health and Sport Sciences, Santa Catarina State University, 88080-350 Florianópolis, SC, BrazilHuman Performance Research Group, Center of Health and Sport Sciences, Santa Catarina State University, 88080-350 Florianópolis, SC, BrazilLactate is a highly dynamic metabolite that can be used as a fuel by several cells of the human body, particularly during physical exercise. Traditionally, it has been believed that the first step of lactate oxidation occurs in cytosol; however, this idea was recently challenged. A new hypothesis has been presented based on the fact that lactate-to-pyruvate conversion cannot occur in cytosol, because the LDH enzyme characteristics and cytosolic environment do not allow the reaction in this way. Instead, the Intracellular Lactate Shuttle hypothesis states that lactate first enters in mitochondria and only then is metabolized. In several tissues of the human body this idea is well accepted but is quite resistant in skeletal muscle. In this paper, we will present not only the studies which are protagonists in this discussion, but the potential mechanism by which this oxidation occurs and also a link between lactate and mitochondrial proliferation. This new perspective brings some implications and comes to change our understanding of the interaction between the energy systems, because the product of one serves as a substrate for the other.http://dx.doi.org/10.1100/2012/420984 |
| spellingShingle | Rogério Santos de Oliveira Cruz Rafael Alves de Aguiar Tiago Turnes Rafael Penteado Dos Santos Mariana Fernandes Mendes de Oliveira Fabrizio Caputo Intracellular Shuttle: The Lactate Aerobic Metabolism The Scientific World Journal |
| title | Intracellular Shuttle: The Lactate Aerobic Metabolism |
| title_full | Intracellular Shuttle: The Lactate Aerobic Metabolism |
| title_fullStr | Intracellular Shuttle: The Lactate Aerobic Metabolism |
| title_full_unstemmed | Intracellular Shuttle: The Lactate Aerobic Metabolism |
| title_short | Intracellular Shuttle: The Lactate Aerobic Metabolism |
| title_sort | intracellular shuttle the lactate aerobic metabolism |
| url | http://dx.doi.org/10.1100/2012/420984 |
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