Acute Stress and Gender Effects in Sensory Gating of the Auditory Evoked Potential in Healthy Subjects
Sensory gating is a neurophysiological measure of inhibition that is characterized by a reduction in the P50, N100, and P200 event-related potentials to a repeated identical stimulus. It was proposed that abnormal sensory gating is involved in the neural pathological basis of some severe mental diso...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2021/8529613 |
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| author | Zengyou Xin Simeng Gu Wei Wang Yi Lei Hong Li |
| author_facet | Zengyou Xin Simeng Gu Wei Wang Yi Lei Hong Li |
| author_sort | Zengyou Xin |
| collection | DOAJ |
| description | Sensory gating is a neurophysiological measure of inhibition that is characterized by a reduction in the P50, N100, and P200 event-related potentials to a repeated identical stimulus. It was proposed that abnormal sensory gating is involved in the neural pathological basis of some severe mental disorders. Since then, the prevailing application of sensory gating measures has been in the study of neuropathology associated with schizophrenia and so on. However, sensory gating is not only trait-like but can be also state-like, and measures of sensory gating seemed to be affected by several factors in healthy subjects. The objective of this work was to clarify the roles of acute stress and gender in sensory gating. Data showed acute stress impaired inhibition of P50 to the second click in the paired-click paradigm without effects on sensory registration leading to worse P50 sensory gating and disrupted attention allocation reflected by attenuated P200 responses than control condition, without gender effects. As for N100 and P200 gating, women showed slightly better than men without effects of acute stress. Data also showed slightly larger N100 amplitudes across clicks and significant larger P200 amplitude to the first click for women, suggesting that women might be more alert than men. |
| format | Article |
| id | doaj-art-1dafd03f934b4dc9a81b87f75a926bc8 |
| institution | OA Journals |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-1dafd03f934b4dc9a81b87f75a926bc82025-08-20T02:01:39ZengWileyNeural Plasticity2090-59041687-54432021-01-01202110.1155/2021/85296138529613Acute Stress and Gender Effects in Sensory Gating of the Auditory Evoked Potential in Healthy SubjectsZengyou Xin0Simeng Gu1Wei Wang2Yi Lei3Hong Li4School of Education Science, Minnan Normal University, Zhangzhou, Fujian 363000, ChinaInstitute of Brain and Psychological Sciences, Sichuan Normal University, Chengdu, Sichuan 610060, ChinaDepartment of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14643, USAInstitute of Brain and Psychological Sciences, Sichuan Normal University, Chengdu, Sichuan 610060, ChinaInstitute of Brain and Psychological Sciences, Sichuan Normal University, Chengdu, Sichuan 610060, ChinaSensory gating is a neurophysiological measure of inhibition that is characterized by a reduction in the P50, N100, and P200 event-related potentials to a repeated identical stimulus. It was proposed that abnormal sensory gating is involved in the neural pathological basis of some severe mental disorders. Since then, the prevailing application of sensory gating measures has been in the study of neuropathology associated with schizophrenia and so on. However, sensory gating is not only trait-like but can be also state-like, and measures of sensory gating seemed to be affected by several factors in healthy subjects. The objective of this work was to clarify the roles of acute stress and gender in sensory gating. Data showed acute stress impaired inhibition of P50 to the second click in the paired-click paradigm without effects on sensory registration leading to worse P50 sensory gating and disrupted attention allocation reflected by attenuated P200 responses than control condition, without gender effects. As for N100 and P200 gating, women showed slightly better than men without effects of acute stress. Data also showed slightly larger N100 amplitudes across clicks and significant larger P200 amplitude to the first click for women, suggesting that women might be more alert than men.http://dx.doi.org/10.1155/2021/8529613 |
| spellingShingle | Zengyou Xin Simeng Gu Wei Wang Yi Lei Hong Li Acute Stress and Gender Effects in Sensory Gating of the Auditory Evoked Potential in Healthy Subjects Neural Plasticity |
| title | Acute Stress and Gender Effects in Sensory Gating of the Auditory Evoked Potential in Healthy Subjects |
| title_full | Acute Stress and Gender Effects in Sensory Gating of the Auditory Evoked Potential in Healthy Subjects |
| title_fullStr | Acute Stress and Gender Effects in Sensory Gating of the Auditory Evoked Potential in Healthy Subjects |
| title_full_unstemmed | Acute Stress and Gender Effects in Sensory Gating of the Auditory Evoked Potential in Healthy Subjects |
| title_short | Acute Stress and Gender Effects in Sensory Gating of the Auditory Evoked Potential in Healthy Subjects |
| title_sort | acute stress and gender effects in sensory gating of the auditory evoked potential in healthy subjects |
| url | http://dx.doi.org/10.1155/2021/8529613 |
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