Establishing correlation between in vitro potency and in vivo immunogenicity for mRNA vaccines
Abstract mRNA vaccines undergo intracellular translation to express the encoded protein antigen in a functionally intact form. To evaluate correlation between in vitro and in vivo measures of potency, mRNA vaccine samples with varying relative potencies can be created by gradual structural destabili...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-06-01
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| Series: | npj Vaccines |
| Online Access: | https://doi.org/10.1038/s41541-025-01181-2 |
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