Liver Transplantation: Evolving Patient Selection Criteria
The widespread recognition of the success of liver transplantation as a treatment for most types of acute and chronic liver failure has led to increased referrals for transplantation in the setting of a relatively fixed supply of cadaver donor organs. These events have led to a marked lengthening of...
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| Format: | Article |
| Language: | English |
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Wiley
2001-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2001/743019 |
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| _version_ | 1832552827771158528 |
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| author | Andy S Yu Aijaz Ahmed Emmet B Keeffe |
| author_facet | Andy S Yu Aijaz Ahmed Emmet B Keeffe |
| author_sort | Andy S Yu |
| collection | DOAJ |
| description | The widespread recognition of the success of liver transplantation as a treatment for most types of acute and chronic liver failure has led to increased referrals for transplantation in the setting of a relatively fixed supply of cadaver donor organs. These events have led to a marked lengthening of the waiting time for liver transplantation, resulting in increased deaths of those on the waiting list and sicker patients undergoing transplantation. Nearly 5000 liver transplantations were performed in the United States in 2000, while the waiting list grew to over 17,000 patients. The mounting disparity between the number of liver transplant candidates and the limited supply of donor organs has led to reassessment of the selection and listing criteria for liver transplantation, as well as revision of organ allocation and distribution policies for cadaver livers. The development of minimal listing criteria for patients with chronic liver disease based on a specific definition for decompensation of cirrhosis has facilitated the more uniform listing of patients at individual centres across the United States. The United Network for Organ Sharing, under pressure from transplant professionals, patient advocacy groups and the federal government, has continuously revised allocation and distribution policies based on the ethical principles of justice for the individual patient versus optimal utility of the limited organ supply available annually. Beginning in 2002, it is likely that the Model for End-stage Liver Disease (MELD) score will be implemented to determine disease severity and direct donor organs to the sickest patients rather than to those with the longest waiting times. |
| format | Article |
| id | doaj-art-1d993ad086c342edba296e1e84581cc3 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2001-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-1d993ad086c342edba296e1e84581cc32025-02-03T05:57:39ZengWileyCanadian Journal of Gastroenterology0835-79002001-01-01151172973810.1155/2001/743019Liver Transplantation: Evolving Patient Selection CriteriaAndy S Yu0Aijaz Ahmed1Emmet B Keeffe2Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USADivision of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USADivision of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USAThe widespread recognition of the success of liver transplantation as a treatment for most types of acute and chronic liver failure has led to increased referrals for transplantation in the setting of a relatively fixed supply of cadaver donor organs. These events have led to a marked lengthening of the waiting time for liver transplantation, resulting in increased deaths of those on the waiting list and sicker patients undergoing transplantation. Nearly 5000 liver transplantations were performed in the United States in 2000, while the waiting list grew to over 17,000 patients. The mounting disparity between the number of liver transplant candidates and the limited supply of donor organs has led to reassessment of the selection and listing criteria for liver transplantation, as well as revision of organ allocation and distribution policies for cadaver livers. The development of minimal listing criteria for patients with chronic liver disease based on a specific definition for decompensation of cirrhosis has facilitated the more uniform listing of patients at individual centres across the United States. The United Network for Organ Sharing, under pressure from transplant professionals, patient advocacy groups and the federal government, has continuously revised allocation and distribution policies based on the ethical principles of justice for the individual patient versus optimal utility of the limited organ supply available annually. Beginning in 2002, it is likely that the Model for End-stage Liver Disease (MELD) score will be implemented to determine disease severity and direct donor organs to the sickest patients rather than to those with the longest waiting times.http://dx.doi.org/10.1155/2001/743019 |
| spellingShingle | Andy S Yu Aijaz Ahmed Emmet B Keeffe Liver Transplantation: Evolving Patient Selection Criteria Canadian Journal of Gastroenterology |
| title | Liver Transplantation: Evolving Patient Selection Criteria |
| title_full | Liver Transplantation: Evolving Patient Selection Criteria |
| title_fullStr | Liver Transplantation: Evolving Patient Selection Criteria |
| title_full_unstemmed | Liver Transplantation: Evolving Patient Selection Criteria |
| title_short | Liver Transplantation: Evolving Patient Selection Criteria |
| title_sort | liver transplantation evolving patient selection criteria |
| url | http://dx.doi.org/10.1155/2001/743019 |
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