Identification and Expression Profiling of the BTB Domain-Containing Protein Gene Family in the Silkworm, Bombyx mori
The BTB domain is a conserved protein-protein interaction motif. In this study, we identified 56 BTB domain-containing protein genes in the silkworm, in addition to 46 in the honey bee, 55 in the red flour beetle, and 53 in the monarch butterfly. Silkworm BTB protein genes were classified into nine...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2014/865065 |
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| author | Daojun Cheng Wenliang Qian Meng Meng Yonghu Wang Jian Peng Qingyou Xia |
| author_facet | Daojun Cheng Wenliang Qian Meng Meng Yonghu Wang Jian Peng Qingyou Xia |
| author_sort | Daojun Cheng |
| collection | DOAJ |
| description | The BTB domain is a conserved protein-protein interaction motif. In this study, we identified 56 BTB domain-containing protein genes in the silkworm, in addition to 46 in the honey bee, 55 in the red flour beetle, and 53 in the monarch butterfly. Silkworm BTB protein genes were classified into nine subfamilies according to their domain architecture, and most of them could be mapped on the different chromosomes. Phylogenetic analysis suggests that silkworm BTB protein genes may have undergone a duplication event in three subfamilies: BTB-BACK-Kelch, BTB-BACK-PHR, and BTB-FLYWCH. Comparative analysis demonstrated that the orthologs of each of 13 BTB protein genes present a rigorous orthologous relationship in the silkworm and other surveyed insects, indicating conserved functions of these genes during insect evolution. Furthermore, several silkworm BTB protein genes exhibited sex-specific expression in larval tissues or at different stages during metamorphosis. These findings not only contribute to a better understanding of the evolution of insect BTB protein gene families but also provide a basis for further investigation of the functions of BTB protein genes in the silkworm. |
| format | Article |
| id | doaj-art-1d8ce64f97234177979ed5403aa7996b |
| institution | Kabale University |
| issn | 2314-436X 2314-4378 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
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| series | International Journal of Genomics |
| spelling | doaj-art-1d8ce64f97234177979ed5403aa7996b2025-02-03T05:45:41ZengWileyInternational Journal of Genomics2314-436X2314-43782014-01-01201410.1155/2014/865065865065Identification and Expression Profiling of the BTB Domain-Containing Protein Gene Family in the Silkworm, Bombyx moriDaojun Cheng0Wenliang Qian1Meng Meng2Yonghu Wang3Jian Peng4Qingyou Xia5State Key Laboratory of Silkworm Genome Biology, Southwest University, No. 2 Tiansheng Street, Beibei District, Chongqing 400715, ChinaState Key Laboratory of Silkworm Genome Biology, Southwest University, No. 2 Tiansheng Street, Beibei District, Chongqing 400715, ChinaState Key Laboratory of Silkworm Genome Biology, Southwest University, No. 2 Tiansheng Street, Beibei District, Chongqing 400715, ChinaState Key Laboratory of Silkworm Genome Biology, Southwest University, No. 2 Tiansheng Street, Beibei District, Chongqing 400715, ChinaState Key Laboratory of Silkworm Genome Biology, Southwest University, No. 2 Tiansheng Street, Beibei District, Chongqing 400715, ChinaState Key Laboratory of Silkworm Genome Biology, Southwest University, No. 2 Tiansheng Street, Beibei District, Chongqing 400715, ChinaThe BTB domain is a conserved protein-protein interaction motif. In this study, we identified 56 BTB domain-containing protein genes in the silkworm, in addition to 46 in the honey bee, 55 in the red flour beetle, and 53 in the monarch butterfly. Silkworm BTB protein genes were classified into nine subfamilies according to their domain architecture, and most of them could be mapped on the different chromosomes. Phylogenetic analysis suggests that silkworm BTB protein genes may have undergone a duplication event in three subfamilies: BTB-BACK-Kelch, BTB-BACK-PHR, and BTB-FLYWCH. Comparative analysis demonstrated that the orthologs of each of 13 BTB protein genes present a rigorous orthologous relationship in the silkworm and other surveyed insects, indicating conserved functions of these genes during insect evolution. Furthermore, several silkworm BTB protein genes exhibited sex-specific expression in larval tissues or at different stages during metamorphosis. These findings not only contribute to a better understanding of the evolution of insect BTB protein gene families but also provide a basis for further investigation of the functions of BTB protein genes in the silkworm.http://dx.doi.org/10.1155/2014/865065 |
| spellingShingle | Daojun Cheng Wenliang Qian Meng Meng Yonghu Wang Jian Peng Qingyou Xia Identification and Expression Profiling of the BTB Domain-Containing Protein Gene Family in the Silkworm, Bombyx mori International Journal of Genomics |
| title | Identification and Expression Profiling of the BTB Domain-Containing Protein Gene Family in the Silkworm, Bombyx mori |
| title_full | Identification and Expression Profiling of the BTB Domain-Containing Protein Gene Family in the Silkworm, Bombyx mori |
| title_fullStr | Identification and Expression Profiling of the BTB Domain-Containing Protein Gene Family in the Silkworm, Bombyx mori |
| title_full_unstemmed | Identification and Expression Profiling of the BTB Domain-Containing Protein Gene Family in the Silkworm, Bombyx mori |
| title_short | Identification and Expression Profiling of the BTB Domain-Containing Protein Gene Family in the Silkworm, Bombyx mori |
| title_sort | identification and expression profiling of the btb domain containing protein gene family in the silkworm bombyx mori |
| url | http://dx.doi.org/10.1155/2014/865065 |
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