Research Progress of Bioactive Peptides in Improving Type II Diabetes

Type II diabetes mellitus (T2DM) is a prevalent, long-standing metabolic condition marked by the body’s reduced response to insulin and inadequate insulin production, impacting a significant portion of the global population. Research has demonstrated that bioactive peptides play a crucial role in re...

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Main Authors: Jiaxin Yu, Guoxing Chen, Yan Jin, Min Zhang, Tao Wu
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Foods
Subjects:
Online Access:https://www.mdpi.com/2304-8158/14/3/340
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author Jiaxin Yu
Guoxing Chen
Yan Jin
Min Zhang
Tao Wu
author_facet Jiaxin Yu
Guoxing Chen
Yan Jin
Min Zhang
Tao Wu
author_sort Jiaxin Yu
collection DOAJ
description Type II diabetes mellitus (T2DM) is a prevalent, long-standing metabolic condition marked by the body’s reduced response to insulin and inadequate insulin production, impacting a significant portion of the global population. Research has demonstrated that bioactive peptides play a crucial role in reducing blood sugar levels, enhancing insulin sensitivity, balancing lipid metabolism, and combating inflammation. These peptides also contribute to the enhancement of pancreatic islet function, lowering systemic inflammation by influencing various molecular signaling pathways. This paper provides an overview of recent advancements and potential applications of bioactive peptides in addressing T2DM. It highlights the diverse impacts of bioactive peptides sourced from different origins in combating diabetes. This comprehensive review offers theoretical substantiation and novel insights to support the future clinical utilization and exploration of bioactive peptides for T2DM management.
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spelling doaj-art-1d806bead54f4af6a826f35b3455d9a02025-08-20T02:12:25ZengMDPI AGFoods2304-81582025-01-0114334010.3390/foods14030340Research Progress of Bioactive Peptides in Improving Type II DiabetesJiaxin Yu0Guoxing Chen1Yan Jin2Min Zhang3Tao Wu4State Key Laboratory of Food Nutrition and Safety, Food Biotechnology Engineering Research Center of Ministry of Education, College of Food Science and Engineering, Tianjin University of Science & Technology, Tianjin 300457, ChinaState Key Laboratory of Food Nutrition and Safety, Food Biotechnology Engineering Research Center of Ministry of Education, College of Food Science and Engineering, Tianjin University of Science & Technology, Tianjin 300457, ChinaState Key Laboratory of Food Nutrition and Safety, Food Biotechnology Engineering Research Center of Ministry of Education, College of Food Science and Engineering, Tianjin University of Science & Technology, Tianjin 300457, ChinaState Key Laboratory of Food Nutrition and Safety, Food Biotechnology Engineering Research Center of Ministry of Education, College of Food Science and Engineering, Tianjin University of Science & Technology, Tianjin 300457, ChinaState Key Laboratory of Food Nutrition and Safety, Food Biotechnology Engineering Research Center of Ministry of Education, College of Food Science and Engineering, Tianjin University of Science & Technology, Tianjin 300457, ChinaType II diabetes mellitus (T2DM) is a prevalent, long-standing metabolic condition marked by the body’s reduced response to insulin and inadequate insulin production, impacting a significant portion of the global population. Research has demonstrated that bioactive peptides play a crucial role in reducing blood sugar levels, enhancing insulin sensitivity, balancing lipid metabolism, and combating inflammation. These peptides also contribute to the enhancement of pancreatic islet function, lowering systemic inflammation by influencing various molecular signaling pathways. This paper provides an overview of recent advancements and potential applications of bioactive peptides in addressing T2DM. It highlights the diverse impacts of bioactive peptides sourced from different origins in combating diabetes. This comprehensive review offers theoretical substantiation and novel insights to support the future clinical utilization and exploration of bioactive peptides for T2DM management.https://www.mdpi.com/2304-8158/14/3/340bioactive peptidestype II diabetes mellitusinsulin resistanceanti-inflammatoryglycolipid metabolism
spellingShingle Jiaxin Yu
Guoxing Chen
Yan Jin
Min Zhang
Tao Wu
Research Progress of Bioactive Peptides in Improving Type II Diabetes
Foods
bioactive peptides
type II diabetes mellitus
insulin resistance
anti-inflammatory
glycolipid metabolism
title Research Progress of Bioactive Peptides in Improving Type II Diabetes
title_full Research Progress of Bioactive Peptides in Improving Type II Diabetes
title_fullStr Research Progress of Bioactive Peptides in Improving Type II Diabetes
title_full_unstemmed Research Progress of Bioactive Peptides in Improving Type II Diabetes
title_short Research Progress of Bioactive Peptides in Improving Type II Diabetes
title_sort research progress of bioactive peptides in improving type ii diabetes
topic bioactive peptides
type II diabetes mellitus
insulin resistance
anti-inflammatory
glycolipid metabolism
url https://www.mdpi.com/2304-8158/14/3/340
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AT yanjin researchprogressofbioactivepeptidesinimprovingtypeiidiabetes
AT minzhang researchprogressofbioactivepeptidesinimprovingtypeiidiabetes
AT taowu researchprogressofbioactivepeptidesinimprovingtypeiidiabetes