Efficacy of Thiamine in the Treatment of Postcardiac Arrest Patients: A Randomized Controlled Study
Background. Thiamine administration has been shown to improve survival in a postcardiac arrest animal study. We aimed to evaluate the efficacy of thiamine in comatose out-of-hospital cardiac arrest (OHCA) patients following return of spontaneous circulation. Methods. A randomized, double-blinded, pl...
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Wiley
2020-01-01
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| Series: | Critical Care Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2020/2981079 |
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| author | Suntornwit Pradita-ukrit Veerapong Vattanavanit |
| author_facet | Suntornwit Pradita-ukrit Veerapong Vattanavanit |
| author_sort | Suntornwit Pradita-ukrit |
| collection | DOAJ |
| description | Background. Thiamine administration has been shown to improve survival in a postcardiac arrest animal study. We aimed to evaluate the efficacy of thiamine in comatose out-of-hospital cardiac arrest (OHCA) patients following return of spontaneous circulation. Methods. A randomized, double-blinded, placebo-controlled study was conducted. Thirty-seven OHCA patients were randomly assigned to receive either thiamine 100 mg every 8 hours or a placebo. The primary outcome was 28-day all-cause mortality. Results. Over the course of 2 years, 37 patients were randomized to either receive thiamine (n = 20) or a placebo (n = 17). The primary outcome was not different between the groups: 10/20 (50%) in the thiamine group vs. 8/17 (47.1%) in the placebo group (P=0.93 by the log-rank test). There were no significant differences in secondary outcomes between the groups (good neurological outcome, lactate level, and S100B level). Conclusions. In this study, there were no significant differences in survival outcome. Further studies with a larger population are necessary to confirm these results. |
| format | Article |
| id | doaj-art-1d7c9cab590540be8230ae556a049342 |
| institution | Kabale University |
| issn | 2090-1305 2090-1313 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Critical Care Research and Practice |
| spelling | doaj-art-1d7c9cab590540be8230ae556a0493422025-02-03T06:43:32ZengWileyCritical Care Research and Practice2090-13052090-13132020-01-01202010.1155/2020/29810792981079Efficacy of Thiamine in the Treatment of Postcardiac Arrest Patients: A Randomized Controlled StudySuntornwit Pradita-ukrit0Veerapong Vattanavanit1Critical Care Medicine Unit, Division of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, ThailandCritical Care Medicine Unit, Division of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, ThailandBackground. Thiamine administration has been shown to improve survival in a postcardiac arrest animal study. We aimed to evaluate the efficacy of thiamine in comatose out-of-hospital cardiac arrest (OHCA) patients following return of spontaneous circulation. Methods. A randomized, double-blinded, placebo-controlled study was conducted. Thirty-seven OHCA patients were randomly assigned to receive either thiamine 100 mg every 8 hours or a placebo. The primary outcome was 28-day all-cause mortality. Results. Over the course of 2 years, 37 patients were randomized to either receive thiamine (n = 20) or a placebo (n = 17). The primary outcome was not different between the groups: 10/20 (50%) in the thiamine group vs. 8/17 (47.1%) in the placebo group (P=0.93 by the log-rank test). There were no significant differences in secondary outcomes between the groups (good neurological outcome, lactate level, and S100B level). Conclusions. In this study, there were no significant differences in survival outcome. Further studies with a larger population are necessary to confirm these results.http://dx.doi.org/10.1155/2020/2981079 |
| spellingShingle | Suntornwit Pradita-ukrit Veerapong Vattanavanit Efficacy of Thiamine in the Treatment of Postcardiac Arrest Patients: A Randomized Controlled Study Critical Care Research and Practice |
| title | Efficacy of Thiamine in the Treatment of Postcardiac Arrest Patients: A Randomized Controlled Study |
| title_full | Efficacy of Thiamine in the Treatment of Postcardiac Arrest Patients: A Randomized Controlled Study |
| title_fullStr | Efficacy of Thiamine in the Treatment of Postcardiac Arrest Patients: A Randomized Controlled Study |
| title_full_unstemmed | Efficacy of Thiamine in the Treatment of Postcardiac Arrest Patients: A Randomized Controlled Study |
| title_short | Efficacy of Thiamine in the Treatment of Postcardiac Arrest Patients: A Randomized Controlled Study |
| title_sort | efficacy of thiamine in the treatment of postcardiac arrest patients a randomized controlled study |
| url | http://dx.doi.org/10.1155/2020/2981079 |
| work_keys_str_mv | AT suntornwitpraditaukrit efficacyofthiamineinthetreatmentofpostcardiacarrestpatientsarandomizedcontrolledstudy AT veerapongvattanavanit efficacyofthiamineinthetreatmentofpostcardiacarrestpatientsarandomizedcontrolledstudy |