Comparison of fluorescence intensity of protoporphyrin IX as observed on the screen of different cystoscopic systems
Background: Photodynamic diagnosis-assisted transurethral resection of bladder tumor (PDD-TURBT) is an important and useful intervention used for removing non-invasive bladder cancer (NMIBC). Several PDD devices can be used in clinical practice, but few reports have compared them.In this study, we e...
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Elsevier
2025-02-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100024004617 |
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| author | Hideo Fukuhara Takahiro Nishimura Yu Shimojo Keiji Inoue |
| author_facet | Hideo Fukuhara Takahiro Nishimura Yu Shimojo Keiji Inoue |
| author_sort | Hideo Fukuhara |
| collection | DOAJ |
| description | Background: Photodynamic diagnosis-assisted transurethral resection of bladder tumor (PDD-TURBT) is an important and useful intervention used for removing non-invasive bladder cancer (NMIBC). Several PDD devices can be used in clinical practice, but few reports have compared them.In this study, we examined the differences in detected fluorescence intensity for each PDD device. Methods: The PDD device was used from OLYMPUS, Richard Wolf, and Karl Storz. Light power and illuminance from endoscope were measured. For each PDD device, fluorescence intensity was measured at 3 cm and 8 cm distance from the protoporphyrin IX (PpIX) phantom to the cystoscope. Results: The variation of excitation light power with observation distance were 35.0 %, 27.0 %, and 28.2 % for OLYMPUS, Richard Wolf, and Karl Storz, respectively. The variation of fluorescence intensity with observation distance were 132.8 %, 120.5 %, and 49.8 % for OLYMPUS, Richard Wolf, and Karl Storz, respectively. Conclusions: PDD devices used in clinical practice show both some performance differences between the PDD systems themselves, and also differences in observed fluorescence intensity. |
| format | Article |
| id | doaj-art-1d79be90b6f24f02a9f8274e78358eac |
| institution | Kabale University |
| issn | 1572-1000 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-1d79be90b6f24f02a9f8274e78358eac2025-02-01T04:11:40ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002025-02-0151104425Comparison of fluorescence intensity of protoporphyrin IX as observed on the screen of different cystoscopic systemsHideo Fukuhara0Takahiro Nishimura1Yu Shimojo2Keiji Inoue3Department of Urology, Kochi Medical School, Kohasu, Oko, Nankoku, Kochi, Japan; Center for Photodynamic Medicine, Kochi Medical School, Kohasu, Oko, Nankoku, Kochi, Japan; Corresponding author at: Department of Urology, Kochi Medical School, Nankoku, Kochi 783-8505, Japan.Graduate School of Engineering, Osaka University, Yamadaoka 2-1, Suita, Osaka, JapanGraduate School of Engineering, Osaka University, Yamadaoka 2-1, Suita, Osaka, Japan; Graduate School of Medicine, Osaka Metropolitan University, Asahimachi 1-4-3, Abeno-ku, Osaka, Japan; Research Fellow of Japan Society for the Promotion of Science, Kojimachi 5-3-1, Chiyoda-ku, Tokyo, JapanDepartment of Urology, Kochi Medical School, Kohasu, Oko, Nankoku, Kochi, Japan; Center for Photodynamic Medicine, Kochi Medical School, Kohasu, Oko, Nankoku, Kochi, JapanBackground: Photodynamic diagnosis-assisted transurethral resection of bladder tumor (PDD-TURBT) is an important and useful intervention used for removing non-invasive bladder cancer (NMIBC). Several PDD devices can be used in clinical practice, but few reports have compared them.In this study, we examined the differences in detected fluorescence intensity for each PDD device. Methods: The PDD device was used from OLYMPUS, Richard Wolf, and Karl Storz. Light power and illuminance from endoscope were measured. For each PDD device, fluorescence intensity was measured at 3 cm and 8 cm distance from the protoporphyrin IX (PpIX) phantom to the cystoscope. Results: The variation of excitation light power with observation distance were 35.0 %, 27.0 %, and 28.2 % for OLYMPUS, Richard Wolf, and Karl Storz, respectively. The variation of fluorescence intensity with observation distance were 132.8 %, 120.5 %, and 49.8 % for OLYMPUS, Richard Wolf, and Karl Storz, respectively. Conclusions: PDD devices used in clinical practice show both some performance differences between the PDD systems themselves, and also differences in observed fluorescence intensity.http://www.sciencedirect.com/science/article/pii/S1572100024004617Photodynamic diagnosisTransurethral resection of bladder tumorPDD deviceFluorescence |
| spellingShingle | Hideo Fukuhara Takahiro Nishimura Yu Shimojo Keiji Inoue Comparison of fluorescence intensity of protoporphyrin IX as observed on the screen of different cystoscopic systems Photodiagnosis and Photodynamic Therapy Photodynamic diagnosis Transurethral resection of bladder tumor PDD device Fluorescence |
| title | Comparison of fluorescence intensity of protoporphyrin IX as observed on the screen of different cystoscopic systems |
| title_full | Comparison of fluorescence intensity of protoporphyrin IX as observed on the screen of different cystoscopic systems |
| title_fullStr | Comparison of fluorescence intensity of protoporphyrin IX as observed on the screen of different cystoscopic systems |
| title_full_unstemmed | Comparison of fluorescence intensity of protoporphyrin IX as observed on the screen of different cystoscopic systems |
| title_short | Comparison of fluorescence intensity of protoporphyrin IX as observed on the screen of different cystoscopic systems |
| title_sort | comparison of fluorescence intensity of protoporphyrin ix as observed on the screen of different cystoscopic systems |
| topic | Photodynamic diagnosis Transurethral resection of bladder tumor PDD device Fluorescence |
| url | http://www.sciencedirect.com/science/article/pii/S1572100024004617 |
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