Association of Psoriasis Severity with Serum Prolactin, Thyroid Hormones, and Cortisol before and after Treatment
Background. Prolactin (PRL) level is proposed to be associated with the severity of psoriasis although the previous studies reported different results. Objective. To find the association between PRL levels and severity of psoriasis before and after treatment. In addition, we aimed to find a differen...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/921819 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832568271213166592 |
|---|---|
| author | Reza M. Robati Parviz Toossi Mohammad Rahmati-Roodsari Sara Khalilazar Ehsan Abolhasani Nastaran Namazi Shima Younespour |
| author_facet | Reza M. Robati Parviz Toossi Mohammad Rahmati-Roodsari Sara Khalilazar Ehsan Abolhasani Nastaran Namazi Shima Younespour |
| author_sort | Reza M. Robati |
| collection | DOAJ |
| description | Background. Prolactin (PRL) level is proposed to be associated with the severity of psoriasis although the previous studies reported different results. Objective. To find the association between PRL levels and severity of psoriasis before and after treatment. In addition, we aimed to find a difference in prolactin, thyroid stimulating hormone (TSH), thyroid hormones (T3 and T4), and cortisol levels between patients with psoriasis and normal controls. Methods. First, the levels of hormones were measured in 30 patients with psoriasis and 30 matched controls. The severity was assessed by psoriasis area and severity index (PASI). Then, patients were treated, and PASI was assessed every week until achieving PASI-75 response. At this time, the hormones were measured again and compared to the baseline. Results. No statistical significant difference was observed in the mean PRL, T3, T4, TSH, and cortisol levels between cases and controls. Comparing to the baseline, a significant decrease in PRL levels and a significant increase in T3 and serum cortisol levels were observed after treatment (P<0.05), while the changes in other hormones were not significant. Conclusion. After treatment, PRL significantly decreased, and T3 and cortisol levels significantly increased. No correlation between hormone levels and improvement of PASI score existed. |
| format | Article |
| id | doaj-art-1d76d51467dc4008b4ba90ba228bcb88 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-1d76d51467dc4008b4ba90ba228bcb882025-02-03T00:59:18ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/921819921819Association of Psoriasis Severity with Serum Prolactin, Thyroid Hormones, and Cortisol before and after TreatmentReza M. Robati0Parviz Toossi1Mohammad Rahmati-Roodsari2Sara Khalilazar3Ehsan Abolhasani4Nastaran Namazi5Shima Younespour6Skin Research Center, Shahid Beheshti University of Medical Sciences, Shohada-e-Tajrish Hospital, Shahrdari Street, Tajrish Square, Tehran, IranSkin Research Center, Shahid Beheshti University of Medical Sciences, Shohada-e-Tajrish Hospital, Shahrdari Street, Tajrish Square, Tehran, IranSkin Research Center, Shahid Beheshti University of Medical Sciences, Shohada-e-Tajrish Hospital, Shahrdari Street, Tajrish Square, Tehran, IranSkin Research Center, Shahid Beheshti University of Medical Sciences, Shohada-e-Tajrish Hospital, Shahrdari Street, Tajrish Square, Tehran, IranSkin Research Center, Shahid Beheshti University of Medical Sciences, Shohada-e-Tajrish Hospital, Shahrdari Street, Tajrish Square, Tehran, IranSkin Research Center, Shahid Beheshti University of Medical Sciences, Shohada-e-Tajrish Hospital, Shahrdari Street, Tajrish Square, Tehran, IranDepartment of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, IranBackground. Prolactin (PRL) level is proposed to be associated with the severity of psoriasis although the previous studies reported different results. Objective. To find the association between PRL levels and severity of psoriasis before and after treatment. In addition, we aimed to find a difference in prolactin, thyroid stimulating hormone (TSH), thyroid hormones (T3 and T4), and cortisol levels between patients with psoriasis and normal controls. Methods. First, the levels of hormones were measured in 30 patients with psoriasis and 30 matched controls. The severity was assessed by psoriasis area and severity index (PASI). Then, patients were treated, and PASI was assessed every week until achieving PASI-75 response. At this time, the hormones were measured again and compared to the baseline. Results. No statistical significant difference was observed in the mean PRL, T3, T4, TSH, and cortisol levels between cases and controls. Comparing to the baseline, a significant decrease in PRL levels and a significant increase in T3 and serum cortisol levels were observed after treatment (P<0.05), while the changes in other hormones were not significant. Conclusion. After treatment, PRL significantly decreased, and T3 and cortisol levels significantly increased. No correlation between hormone levels and improvement of PASI score existed.http://dx.doi.org/10.1155/2013/921819 |
| spellingShingle | Reza M. Robati Parviz Toossi Mohammad Rahmati-Roodsari Sara Khalilazar Ehsan Abolhasani Nastaran Namazi Shima Younespour Association of Psoriasis Severity with Serum Prolactin, Thyroid Hormones, and Cortisol before and after Treatment The Scientific World Journal |
| title | Association of Psoriasis Severity with Serum Prolactin, Thyroid Hormones, and Cortisol before and after Treatment |
| title_full | Association of Psoriasis Severity with Serum Prolactin, Thyroid Hormones, and Cortisol before and after Treatment |
| title_fullStr | Association of Psoriasis Severity with Serum Prolactin, Thyroid Hormones, and Cortisol before and after Treatment |
| title_full_unstemmed | Association of Psoriasis Severity with Serum Prolactin, Thyroid Hormones, and Cortisol before and after Treatment |
| title_short | Association of Psoriasis Severity with Serum Prolactin, Thyroid Hormones, and Cortisol before and after Treatment |
| title_sort | association of psoriasis severity with serum prolactin thyroid hormones and cortisol before and after treatment |
| url | http://dx.doi.org/10.1155/2013/921819 |
| work_keys_str_mv | AT rezamrobati associationofpsoriasisseveritywithserumprolactinthyroidhormonesandcortisolbeforeandaftertreatment AT parviztoossi associationofpsoriasisseveritywithserumprolactinthyroidhormonesandcortisolbeforeandaftertreatment AT mohammadrahmatiroodsari associationofpsoriasisseveritywithserumprolactinthyroidhormonesandcortisolbeforeandaftertreatment AT sarakhalilazar associationofpsoriasisseveritywithserumprolactinthyroidhormonesandcortisolbeforeandaftertreatment AT ehsanabolhasani associationofpsoriasisseveritywithserumprolactinthyroidhormonesandcortisolbeforeandaftertreatment AT nastarannamazi associationofpsoriasisseveritywithserumprolactinthyroidhormonesandcortisolbeforeandaftertreatment AT shimayounespour associationofpsoriasisseveritywithserumprolactinthyroidhormonesandcortisolbeforeandaftertreatment |