Development and In-Vitro Evaluation of pH Responsive Polymeric Nano Hydrogel Carrier System for Gastro-Protective Delivery of Naproxen Sodium
Current research work was carried out for gastro-protective delivery of naproxen sodium. Polyethylene glycol-g-poly (methacrylic acid) nanogels was developed through free radical polymerization technique. Formulation was characterized for swelling behaviour, entrapment efficiency, Fourier transform...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Advances in Polymer Technology |
| Online Access: | http://dx.doi.org/10.1155/2019/6090965 |
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| author | Rai Muhammad Sarfraz Muhammad Rouf Akram Muhammad Rizwan Ali Asif Mahmood Muhammad Usman Khan Husnain Ahmad Muhammad Naeem Qaisar |
| author_facet | Rai Muhammad Sarfraz Muhammad Rouf Akram Muhammad Rizwan Ali Asif Mahmood Muhammad Usman Khan Husnain Ahmad Muhammad Naeem Qaisar |
| author_sort | Rai Muhammad Sarfraz |
| collection | DOAJ |
| description | Current research work was carried out for gastro-protective delivery of naproxen sodium. Polyethylene glycol-g-poly (methacrylic acid) nanogels was developed through free radical polymerization technique. Formulation was characterized for swelling behaviour, entrapment efficiency, Fourier transform infrared (FTIR) spectroscopy, Differential scanning calorimetry (DSC), and Thermal Gravimetric Analysis (TGA), Powder X-ray diffraction (PXRD), Zeta size distribution, and Zeta potential measurements, and in-vitro drug release. pH dependent swelling was observed with maximum drug release at higher pH. PXRD studies confirmed the conversion of loaded drug from crystalline to amorphous form while Zeta size measurement showed size reduction. On the basis of these results it was concluded that prepared nanogels proved an effective tool for gastro-protective delivery of naproxen sodium. |
| format | Article |
| id | doaj-art-1d71322b3db34e85b0917e80ff2f1220 |
| institution | Kabale University |
| issn | 0730-6679 1098-2329 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Polymer Technology |
| spelling | doaj-art-1d71322b3db34e85b0917e80ff2f12202025-02-03T01:27:09ZengWileyAdvances in Polymer Technology0730-66791098-23292019-01-01201910.1155/2019/60909656090965Development and In-Vitro Evaluation of pH Responsive Polymeric Nano Hydrogel Carrier System for Gastro-Protective Delivery of Naproxen SodiumRai Muhammad Sarfraz0Muhammad Rouf Akram1Muhammad Rizwan Ali2Asif Mahmood3Muhammad Usman Khan4Husnain Ahmad5Muhammad Naeem Qaisar6College of Pharmacy, University of Sargodha, Sargodha 40100, Punjab, PakistanCollege of Pharmacy, University of Sargodha, Sargodha 40100, Punjab, PakistanCollege of Pharmacy, University of Sargodha, Sargodha 40100, Punjab, PakistanDepartment of Pharmaceutics, Faculty of Pharmacy, University of Lahore, Lahore, PakistanCollege of Pharmacy, University of Sargodha, Sargodha 40100, Punjab, PakistanCollege of Pharmacy, University of Sargodha, Sargodha 40100, Punjab, PakistanCollege of Pharmacy, University of Sargodha, Sargodha 40100, Punjab, PakistanCurrent research work was carried out for gastro-protective delivery of naproxen sodium. Polyethylene glycol-g-poly (methacrylic acid) nanogels was developed through free radical polymerization technique. Formulation was characterized for swelling behaviour, entrapment efficiency, Fourier transform infrared (FTIR) spectroscopy, Differential scanning calorimetry (DSC), and Thermal Gravimetric Analysis (TGA), Powder X-ray diffraction (PXRD), Zeta size distribution, and Zeta potential measurements, and in-vitro drug release. pH dependent swelling was observed with maximum drug release at higher pH. PXRD studies confirmed the conversion of loaded drug from crystalline to amorphous form while Zeta size measurement showed size reduction. On the basis of these results it was concluded that prepared nanogels proved an effective tool for gastro-protective delivery of naproxen sodium.http://dx.doi.org/10.1155/2019/6090965 |
| spellingShingle | Rai Muhammad Sarfraz Muhammad Rouf Akram Muhammad Rizwan Ali Asif Mahmood Muhammad Usman Khan Husnain Ahmad Muhammad Naeem Qaisar Development and In-Vitro Evaluation of pH Responsive Polymeric Nano Hydrogel Carrier System for Gastro-Protective Delivery of Naproxen Sodium Advances in Polymer Technology |
| title | Development and In-Vitro Evaluation of pH Responsive Polymeric Nano Hydrogel Carrier System for Gastro-Protective Delivery of Naproxen Sodium |
| title_full | Development and In-Vitro Evaluation of pH Responsive Polymeric Nano Hydrogel Carrier System for Gastro-Protective Delivery of Naproxen Sodium |
| title_fullStr | Development and In-Vitro Evaluation of pH Responsive Polymeric Nano Hydrogel Carrier System for Gastro-Protective Delivery of Naproxen Sodium |
| title_full_unstemmed | Development and In-Vitro Evaluation of pH Responsive Polymeric Nano Hydrogel Carrier System for Gastro-Protective Delivery of Naproxen Sodium |
| title_short | Development and In-Vitro Evaluation of pH Responsive Polymeric Nano Hydrogel Carrier System for Gastro-Protective Delivery of Naproxen Sodium |
| title_sort | development and in vitro evaluation of ph responsive polymeric nano hydrogel carrier system for gastro protective delivery of naproxen sodium |
| url | http://dx.doi.org/10.1155/2019/6090965 |
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