A concise review on bioactive pentacyclic triterpenoids of Centella asiatica (Gotu Kola)
Abstract Centella asiatica (L.) Urb. is a species of herbaceous plant native to the tropic and subtropical regions of Southeast Asia, China, and India. It is commonly referred to as "Gotu kola" in India. For hundreds of years, this well-known folk remedy has been used in Chinese and Indian...
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Springer
2025-03-01
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| Series: | Discover Chemistry |
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| Online Access: | https://doi.org/10.1007/s44371-025-00120-3 |
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| author | Kajim Ali Sudhir Kumar Mohammad Faheem Khan |
| author_facet | Kajim Ali Sudhir Kumar Mohammad Faheem Khan |
| author_sort | Kajim Ali |
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| description | Abstract Centella asiatica (L.) Urb. is a species of herbaceous plant native to the tropic and subtropical regions of Southeast Asia, China, and India. It is commonly referred to as "Gotu kola" in India. For hundreds of years, this well-known folk remedy has been used in Chinese and Indian traditional medicine to promote brain function, prevent cognitive impairments, and enhance memory. Major constituents with a range of pharmacological properties, such as antioxidant, anti-inflammatory, antibacterial, anticancer, hepatoprotective, immunomodulatory, neuroprotective, cardioprotective, and wound healing properties, have been identified as pentacyclic triterpenoids, including asiaticoside, madecassoside, asiatic acid, and madecassic acid. In the present work, we compiled the details from earlier literature containing research data regarding the isolation, purification, and pharmacological properties of 57 pentacyclic triterpenoids that were extracted from various parts of this plant using multiple chromatographic methods. The isolation yields, pharmacological properties, and structure–activity relationship (SAR) analysis are also addressed. |
| format | Article |
| id | doaj-art-1d70fdbcc6444d9a8c450aaea1137f5e |
| institution | OA Journals |
| issn | 3005-1193 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Chemistry |
| spelling | doaj-art-1d70fdbcc6444d9a8c450aaea1137f5e2025-08-20T02:10:17ZengSpringerDiscover Chemistry3005-11932025-03-012112110.1007/s44371-025-00120-3A concise review on bioactive pentacyclic triterpenoids of Centella asiatica (Gotu Kola)Kajim Ali0Sudhir Kumar1Mohammad Faheem Khan2Department of Zoology, University of LucknowDepartment of Zoology, University of LucknowDepartment of Biotechnology, Era’s Lucknow Medical College & Hospital, Era UniversityAbstract Centella asiatica (L.) Urb. is a species of herbaceous plant native to the tropic and subtropical regions of Southeast Asia, China, and India. It is commonly referred to as "Gotu kola" in India. For hundreds of years, this well-known folk remedy has been used in Chinese and Indian traditional medicine to promote brain function, prevent cognitive impairments, and enhance memory. Major constituents with a range of pharmacological properties, such as antioxidant, anti-inflammatory, antibacterial, anticancer, hepatoprotective, immunomodulatory, neuroprotective, cardioprotective, and wound healing properties, have been identified as pentacyclic triterpenoids, including asiaticoside, madecassoside, asiatic acid, and madecassic acid. In the present work, we compiled the details from earlier literature containing research data regarding the isolation, purification, and pharmacological properties of 57 pentacyclic triterpenoids that were extracted from various parts of this plant using multiple chromatographic methods. The isolation yields, pharmacological properties, and structure–activity relationship (SAR) analysis are also addressed.https://doi.org/10.1007/s44371-025-00120-3Centella asiaticaGotu kolaPentacyclic TriterpenoidsAsiaticosideMadecassosideAsiatic acid |
| spellingShingle | Kajim Ali Sudhir Kumar Mohammad Faheem Khan A concise review on bioactive pentacyclic triterpenoids of Centella asiatica (Gotu Kola) Discover Chemistry Centella asiatica Gotu kola Pentacyclic Triterpenoids Asiaticoside Madecassoside Asiatic acid |
| title | A concise review on bioactive pentacyclic triterpenoids of Centella asiatica (Gotu Kola) |
| title_full | A concise review on bioactive pentacyclic triterpenoids of Centella asiatica (Gotu Kola) |
| title_fullStr | A concise review on bioactive pentacyclic triterpenoids of Centella asiatica (Gotu Kola) |
| title_full_unstemmed | A concise review on bioactive pentacyclic triterpenoids of Centella asiatica (Gotu Kola) |
| title_short | A concise review on bioactive pentacyclic triterpenoids of Centella asiatica (Gotu Kola) |
| title_sort | concise review on bioactive pentacyclic triterpenoids of centella asiatica gotu kola |
| topic | Centella asiatica Gotu kola Pentacyclic Triterpenoids Asiaticoside Madecassoside Asiatic acid |
| url | https://doi.org/10.1007/s44371-025-00120-3 |
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