Lipopolysaccharide Binding Protein and sCD14 are Not Produced as Acute Phase Proteins in Cardiac Surgery
Objectives. The changes in the serum levels of lipopolysaccharide binding protein (LBP) and sCD14 during cardiac surgery were followed in this study. Design. Thirty-four patients, 17 in each group, were randomly assigned to coronary artery bypass grafting surgery performed either with...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2007-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2007/72356 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Objectives. The changes in the serum levels of lipopolysaccharide binding protein
(LBP) and sCD14 during cardiac surgery were followed in this study.
Design. Thirty-four patients, 17 in each group, were randomly assigned to coronary artery
bypass grafting surgery
performed either with (“on-pump”) or without (“off-pump”) cardiopulmonary
bypass. LBP and sCD14 were evaluated
by ELISA. Results. The serum levels of LBP were gradually increased from the 1st
postoperative day and reached their
maximum on the 3rd postoperative day in both “on-pump” and
“off-pump” patients (30.33±9.96μg/mL; 37.99±16.58μg/mL), respectively.
There were no significant differences between “on-pump” and “off-pump” patients
regarding LBP. The significantly increased levels of sCD14
from the 1st up to the 7th postoperative day in both “on-pump”
and “off-pump” patients were found with no significant differences between these groups. No
correlations between LBP and sCD14 and IL-6, CRP and long pentraxin PTX3 levels were found.
Conclusions. The levels of LBP and sCD14 are elevated in cardiac surgical patients being
similar in both groups.
These molecules are not produced as acute phase proteins in these patients. |
|---|---|
| ISSN: | 0962-9351 1466-1861 |