Determinants of Brachial-Ankle Pulse Wave Velocity in Chinese Patients with Rheumatoid Arthritis
Objective. To investigate the relationship between Brachial-ankle pulse wave velocity (baPWV), and its associated risk factors in Chinese patients with RA. Methods. 138 Chinese RA patients and 150 healthy subjects were included. baPWV of all the participants was measured. RA related factors were de...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/342869 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832554204326002688 |
|---|---|
| author | Ping Li Cheng-xun Han Cui-li Ma Jia-long Guo Bo Liu Juan Du Li-qi Bi |
| author_facet | Ping Li Cheng-xun Han Cui-li Ma Jia-long Guo Bo Liu Juan Du Li-qi Bi |
| author_sort | Ping Li |
| collection | DOAJ |
| description | Objective. To investigate the relationship between Brachial-ankle pulse wave velocity (baPWV), and its associated risk factors in Chinese patients with RA.
Methods. 138 Chinese RA patients and 150 healthy subjects were included. baPWV of all the participants was measured. RA related factors were determined, as well as traditional cardiovascular risk factors.
Results. baPWV was significant higher in RA group (1705.44 ± 429.20 cm/s) compared to the healthy control group (1386.23 ± 411.09 cm/s) (P<0.001). Compared with low baPWV group, high baPWV group patients were significantly older (P = 0.008) and taller (P = 0.033). Serum cholesterol (P = 0.035), triglycerides (P = 0.004), and LDL level (P = 0.006) were significantly higher in high baPWV group patients compared with low baPWV group patients. The baPWV of RA patients was positively correlated with age (r = 0.439, P<0.001), and serum cholesterol level (r = 0.231, P = 0.035), serum triglycerides level (r = 0.293, P<0.001), serum LDL level (r = 0.323, P = 0.003). Meanwhile, baPWV negatively correlated with the height of RA patients (r = −0.253, P = 0.043). Multivariate regression analysis showed that baPWV of RA group was independently associated with age and serum triglycerides level. Conclusions. The old age and high level of serum triglycerides may be the major determinants of arterial stiffness in Chinese RA patients. |
| format | Article |
| id | doaj-art-1d6cd31e6eac458a8949abd5a4b3f31d |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-1d6cd31e6eac458a8949abd5a4b3f31d2025-02-03T05:52:09ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/342869342869Determinants of Brachial-Ankle Pulse Wave Velocity in Chinese Patients with Rheumatoid ArthritisPing Li0Cheng-xun Han1Cui-li Ma2Jia-long Guo3Bo Liu4Juan Du5Li-qi Bi6Department of Rheumatology and Immunology, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, ChinaDepartment of Rheumatology and Immunology, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, ChinaDepartment of Rheumatology and Immunology, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, ChinaDepartment of Rheumatology and Immunology, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, ChinaDepartment of Rheumatology and Immunology, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, ChinaDepartment of Rheumatology and Immunology, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, ChinaDepartment of Rheumatology and Immunology, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, ChinaObjective. To investigate the relationship between Brachial-ankle pulse wave velocity (baPWV), and its associated risk factors in Chinese patients with RA. Methods. 138 Chinese RA patients and 150 healthy subjects were included. baPWV of all the participants was measured. RA related factors were determined, as well as traditional cardiovascular risk factors. Results. baPWV was significant higher in RA group (1705.44 ± 429.20 cm/s) compared to the healthy control group (1386.23 ± 411.09 cm/s) (P<0.001). Compared with low baPWV group, high baPWV group patients were significantly older (P = 0.008) and taller (P = 0.033). Serum cholesterol (P = 0.035), triglycerides (P = 0.004), and LDL level (P = 0.006) were significantly higher in high baPWV group patients compared with low baPWV group patients. The baPWV of RA patients was positively correlated with age (r = 0.439, P<0.001), and serum cholesterol level (r = 0.231, P = 0.035), serum triglycerides level (r = 0.293, P<0.001), serum LDL level (r = 0.323, P = 0.003). Meanwhile, baPWV negatively correlated with the height of RA patients (r = −0.253, P = 0.043). Multivariate regression analysis showed that baPWV of RA group was independently associated with age and serum triglycerides level. Conclusions. The old age and high level of serum triglycerides may be the major determinants of arterial stiffness in Chinese RA patients.http://dx.doi.org/10.1155/2013/342869 |
| spellingShingle | Ping Li Cheng-xun Han Cui-li Ma Jia-long Guo Bo Liu Juan Du Li-qi Bi Determinants of Brachial-Ankle Pulse Wave Velocity in Chinese Patients with Rheumatoid Arthritis Clinical and Developmental Immunology |
| title | Determinants of Brachial-Ankle Pulse Wave Velocity in Chinese Patients with Rheumatoid Arthritis |
| title_full | Determinants of Brachial-Ankle Pulse Wave Velocity in Chinese Patients with Rheumatoid Arthritis |
| title_fullStr | Determinants of Brachial-Ankle Pulse Wave Velocity in Chinese Patients with Rheumatoid Arthritis |
| title_full_unstemmed | Determinants of Brachial-Ankle Pulse Wave Velocity in Chinese Patients with Rheumatoid Arthritis |
| title_short | Determinants of Brachial-Ankle Pulse Wave Velocity in Chinese Patients with Rheumatoid Arthritis |
| title_sort | determinants of brachial ankle pulse wave velocity in chinese patients with rheumatoid arthritis |
| url | http://dx.doi.org/10.1155/2013/342869 |
| work_keys_str_mv | AT pingli determinantsofbrachialanklepulsewavevelocityinchinesepatientswithrheumatoidarthritis AT chengxunhan determinantsofbrachialanklepulsewavevelocityinchinesepatientswithrheumatoidarthritis AT cuilima determinantsofbrachialanklepulsewavevelocityinchinesepatientswithrheumatoidarthritis AT jialongguo determinantsofbrachialanklepulsewavevelocityinchinesepatientswithrheumatoidarthritis AT boliu determinantsofbrachialanklepulsewavevelocityinchinesepatientswithrheumatoidarthritis AT juandu determinantsofbrachialanklepulsewavevelocityinchinesepatientswithrheumatoidarthritis AT liqibi determinantsofbrachialanklepulsewavevelocityinchinesepatientswithrheumatoidarthritis |