Changes in gut microbiota after gastric cancer surgery: a prospective longitudinal study
BackgroundThis study was designed to characterize gut microbiota changes of the patients with gastric cancer before and after the gastrectomy during their hospital staying periods.Methods16S ribosomal RNA (rRNA) gene sequencing was used to evaluate differences in gut microbiota among patients with g...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1533816/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832591893880373248 |
|---|---|
| author | Yuhua He Shilin Gao Lili Jiang Jie Yang |
| author_facet | Yuhua He Shilin Gao Lili Jiang Jie Yang |
| author_sort | Yuhua He |
| collection | DOAJ |
| description | BackgroundThis study was designed to characterize gut microbiota changes of the patients with gastric cancer before and after the gastrectomy during their hospital staying periods.Methods16S ribosomal RNA (rRNA) gene sequencing was used to evaluate differences in gut microbiota among patients with gastric cancer before and after the gastrectomy by comparing gut microbiota α diversity, β diversity, and structure composition at different taxonomic levels.ResultsA total of 120 fecal specimens were collected from 60 patients. There was no significant difference in Chao1 index, Shannon index, and Simpson index before and after gastrectomy (all P > 0.05). At the phylum level, the gut microbiota in the gastrectomy group showed less abundance of Bacteroidota, Synergistota, and Verrucomicrobiota but with higher abundance of Campylobacter, Actinobacteria, and Bacillota. At the genus level, the gut microbiota in the gastrectomy group showed less abundance of flora Bacteroides, Faecalibacterium, Blautia, and Lachnospiraceae nk4a136 group but with higher abundance of Campylobacter, Porphyromona, Finegordia, Dialist, Anaerococcus, and Corynebacterium.ConclusionsThere was no significant change in the diversity of intestinal flora before and after surgery. However, significant changes in the structure of intestinal flora before and after surgery were occurred. |
| format | Article |
| id | doaj-art-1d62a91aa47a4681a3389e0acef5c478 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-1d62a91aa47a4681a3389e0acef5c4782025-01-22T05:19:24ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011410.3389/fonc.2024.15338161533816Changes in gut microbiota after gastric cancer surgery: a prospective longitudinal studyYuhua HeShilin GaoLili JiangJie YangBackgroundThis study was designed to characterize gut microbiota changes of the patients with gastric cancer before and after the gastrectomy during their hospital staying periods.Methods16S ribosomal RNA (rRNA) gene sequencing was used to evaluate differences in gut microbiota among patients with gastric cancer before and after the gastrectomy by comparing gut microbiota α diversity, β diversity, and structure composition at different taxonomic levels.ResultsA total of 120 fecal specimens were collected from 60 patients. There was no significant difference in Chao1 index, Shannon index, and Simpson index before and after gastrectomy (all P > 0.05). At the phylum level, the gut microbiota in the gastrectomy group showed less abundance of Bacteroidota, Synergistota, and Verrucomicrobiota but with higher abundance of Campylobacter, Actinobacteria, and Bacillota. At the genus level, the gut microbiota in the gastrectomy group showed less abundance of flora Bacteroides, Faecalibacterium, Blautia, and Lachnospiraceae nk4a136 group but with higher abundance of Campylobacter, Porphyromona, Finegordia, Dialist, Anaerococcus, and Corynebacterium.ConclusionsThere was no significant change in the diversity of intestinal flora before and after surgery. However, significant changes in the structure of intestinal flora before and after surgery were occurred.https://www.frontiersin.org/articles/10.3389/fonc.2024.1533816/fullgastric cancergut microbiotahigh-throughput sequencingsurgerybacteria |
| spellingShingle | Yuhua He Shilin Gao Lili Jiang Jie Yang Changes in gut microbiota after gastric cancer surgery: a prospective longitudinal study Frontiers in Oncology gastric cancer gut microbiota high-throughput sequencing surgery bacteria |
| title | Changes in gut microbiota after gastric cancer surgery: a prospective longitudinal study |
| title_full | Changes in gut microbiota after gastric cancer surgery: a prospective longitudinal study |
| title_fullStr | Changes in gut microbiota after gastric cancer surgery: a prospective longitudinal study |
| title_full_unstemmed | Changes in gut microbiota after gastric cancer surgery: a prospective longitudinal study |
| title_short | Changes in gut microbiota after gastric cancer surgery: a prospective longitudinal study |
| title_sort | changes in gut microbiota after gastric cancer surgery a prospective longitudinal study |
| topic | gastric cancer gut microbiota high-throughput sequencing surgery bacteria |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1533816/full |
| work_keys_str_mv | AT yuhuahe changesingutmicrobiotaaftergastriccancersurgeryaprospectivelongitudinalstudy AT shilingao changesingutmicrobiotaaftergastriccancersurgeryaprospectivelongitudinalstudy AT lilijiang changesingutmicrobiotaaftergastriccancersurgeryaprospectivelongitudinalstudy AT jieyang changesingutmicrobiotaaftergastriccancersurgeryaprospectivelongitudinalstudy |