Increased FGF-19 levels following explantation in women with breast implant illness
Abstract Breast Implant Illness (BII) is characterized by a cluster of systemic and local symptoms affecting a subset of women with silicone breast implants. While symptom improvement is frequently observed following implant removal, the underlying mechanisms remain poorly understood, and the absenc...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-88013-4 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832571842043314176 |
|---|---|
| author | S. Azahaf K. A. Spit C. J. M. de Blok P. W. B. Nanayakkara |
| author_facet | S. Azahaf K. A. Spit C. J. M. de Blok P. W. B. Nanayakkara |
| author_sort | S. Azahaf |
| collection | DOAJ |
| description | Abstract Breast Implant Illness (BII) is characterized by a cluster of systemic and local symptoms affecting a subset of women with silicone breast implants. While symptom improvement is frequently observed following implant removal, the underlying mechanisms remain poorly understood, and the absence of reliable biomarkers complicates clinical decision-making. Here, we investigate inflammatory protein profiles in 43 women with BII, comparing pre- and post-explantation levels using the Olink Target 96 Inflammation panel and Meso Scale Discovery technology for absolute quantification. Sixteen inflammatory proteins, including MCP-1, CD8A, and CCL11, were elevated post-explantation, with FGF-19 showing the most pronounced increase (64%). FGF-19 levels increased from a median of 136 pg/mL to 195 pg/mL (p = 0.001), comparable to levels in women with silicone breast implants but no BII. We propose that explantation may alleviate FGF-19 signaling disruption, restoring its metabolic benefits. These findings suggest FGF-19 as a potential diagnostic and therapeutic marker for BII, warranting further investigation. |
| format | Article |
| id | doaj-art-1d624cd4875743f3a9e8817c28a86a80 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-1d624cd4875743f3a9e8817c28a86a802025-02-02T12:15:49ZengNature PortfolioScientific Reports2045-23222025-01-0115111110.1038/s41598-025-88013-4Increased FGF-19 levels following explantation in women with breast implant illnessS. Azahaf0K. A. Spit1C. J. M. de Blok2P. W. B. Nanayakkara3Section General Internal Medicine, Department of Internal Medicine, Amsterdam University Medical CentresSection General Internal Medicine, Department of Internal Medicine, Amsterdam University Medical CentresSection General Internal Medicine, Department of Internal Medicine, Amsterdam University Medical CentresSection General Internal Medicine, Department of Internal Medicine, Amsterdam University Medical CentresAbstract Breast Implant Illness (BII) is characterized by a cluster of systemic and local symptoms affecting a subset of women with silicone breast implants. While symptom improvement is frequently observed following implant removal, the underlying mechanisms remain poorly understood, and the absence of reliable biomarkers complicates clinical decision-making. Here, we investigate inflammatory protein profiles in 43 women with BII, comparing pre- and post-explantation levels using the Olink Target 96 Inflammation panel and Meso Scale Discovery technology for absolute quantification. Sixteen inflammatory proteins, including MCP-1, CD8A, and CCL11, were elevated post-explantation, with FGF-19 showing the most pronounced increase (64%). FGF-19 levels increased from a median of 136 pg/mL to 195 pg/mL (p = 0.001), comparable to levels in women with silicone breast implants but no BII. We propose that explantation may alleviate FGF-19 signaling disruption, restoring its metabolic benefits. These findings suggest FGF-19 as a potential diagnostic and therapeutic marker for BII, warranting further investigation.https://doi.org/10.1038/s41598-025-88013-4 |
| spellingShingle | S. Azahaf K. A. Spit C. J. M. de Blok P. W. B. Nanayakkara Increased FGF-19 levels following explantation in women with breast implant illness Scientific Reports |
| title | Increased FGF-19 levels following explantation in women with breast implant illness |
| title_full | Increased FGF-19 levels following explantation in women with breast implant illness |
| title_fullStr | Increased FGF-19 levels following explantation in women with breast implant illness |
| title_full_unstemmed | Increased FGF-19 levels following explantation in women with breast implant illness |
| title_short | Increased FGF-19 levels following explantation in women with breast implant illness |
| title_sort | increased fgf 19 levels following explantation in women with breast implant illness |
| url | https://doi.org/10.1038/s41598-025-88013-4 |
| work_keys_str_mv | AT sazahaf increasedfgf19levelsfollowingexplantationinwomenwithbreastimplantillness AT kaspit increasedfgf19levelsfollowingexplantationinwomenwithbreastimplantillness AT cjmdeblok increasedfgf19levelsfollowingexplantationinwomenwithbreastimplantillness AT pwbnanayakkara increasedfgf19levelsfollowingexplantationinwomenwithbreastimplantillness |