Reactive Oxygen Species, a Potential Therapeutic Target for Vascular Dementia
Vascular dementia (VaD) is a progressive neurodegenerative condition prevalent among elderly adults marked by cognitive decline resulting from injured and/or improperly functioning cerebrovasculature with resultant disruptions in cerebral blood flow. Currently, VaD has no specific therapeutics and t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/15/1/6 |
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| author | Amanda Louise White Grant M. Talkington Blake Ouvrier Saifudeen Ismael Rebecca J. Solch-Ottaiano Gregory Bix |
| author_facet | Amanda Louise White Grant M. Talkington Blake Ouvrier Saifudeen Ismael Rebecca J. Solch-Ottaiano Gregory Bix |
| author_sort | Amanda Louise White |
| collection | DOAJ |
| description | Vascular dementia (VaD) is a progressive neurodegenerative condition prevalent among elderly adults marked by cognitive decline resulting from injured and/or improperly functioning cerebrovasculature with resultant disruptions in cerebral blood flow. Currently, VaD has no specific therapeutics and the exact pathobiology is still being investigated. VaD has been shown to develop when reactive oxygen species (ROS) form from damaged targets at different levels of organization—mitochondria, endothelial cells, or cerebrovasculature. In this review, we highlight how specific ROS molecules may be important in the development of VaD and how they can be targeted as a potential therapeutic for VaD. |
| format | Article |
| id | doaj-art-1d5fe03b605f4e909088cbda8fe68ba6 |
| institution | Kabale University |
| issn | 2218-273X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-1d5fe03b605f4e909088cbda8fe68ba62025-01-24T13:24:50ZengMDPI AGBiomolecules2218-273X2024-12-01151610.3390/biom15010006Reactive Oxygen Species, a Potential Therapeutic Target for Vascular DementiaAmanda Louise White0Grant M. Talkington1Blake Ouvrier2Saifudeen Ismael3Rebecca J. Solch-Ottaiano4Gregory Bix5Clinical Neuroscience Research Center, Department of Neurosurgery, Tulane University School of Medicine, New Orleans, LA 70112, USAClinical Neuroscience Research Center, Department of Neurosurgery, Tulane University School of Medicine, New Orleans, LA 70112, USAClinical Neuroscience Research Center, Department of Neurosurgery, Tulane University School of Medicine, New Orleans, LA 70112, USAClinical Neuroscience Research Center, Department of Neurosurgery, Tulane University School of Medicine, New Orleans, LA 70112, USAClinical Neuroscience Research Center, Department of Neurosurgery, Tulane University School of Medicine, New Orleans, LA 70112, USAClinical Neuroscience Research Center, Department of Neurosurgery, Tulane University School of Medicine, New Orleans, LA 70112, USAVascular dementia (VaD) is a progressive neurodegenerative condition prevalent among elderly adults marked by cognitive decline resulting from injured and/or improperly functioning cerebrovasculature with resultant disruptions in cerebral blood flow. Currently, VaD has no specific therapeutics and the exact pathobiology is still being investigated. VaD has been shown to develop when reactive oxygen species (ROS) form from damaged targets at different levels of organization—mitochondria, endothelial cells, or cerebrovasculature. In this review, we highlight how specific ROS molecules may be important in the development of VaD and how they can be targeted as a potential therapeutic for VaD.https://www.mdpi.com/2218-273X/15/1/6vascular dementiaAlzheimer’s diseaseantioxidantsreactive oxygen speciestherapeutic |
| spellingShingle | Amanda Louise White Grant M. Talkington Blake Ouvrier Saifudeen Ismael Rebecca J. Solch-Ottaiano Gregory Bix Reactive Oxygen Species, a Potential Therapeutic Target for Vascular Dementia Biomolecules vascular dementia Alzheimer’s disease antioxidants reactive oxygen species therapeutic |
| title | Reactive Oxygen Species, a Potential Therapeutic Target for Vascular Dementia |
| title_full | Reactive Oxygen Species, a Potential Therapeutic Target for Vascular Dementia |
| title_fullStr | Reactive Oxygen Species, a Potential Therapeutic Target for Vascular Dementia |
| title_full_unstemmed | Reactive Oxygen Species, a Potential Therapeutic Target for Vascular Dementia |
| title_short | Reactive Oxygen Species, a Potential Therapeutic Target for Vascular Dementia |
| title_sort | reactive oxygen species a potential therapeutic target for vascular dementia |
| topic | vascular dementia Alzheimer’s disease antioxidants reactive oxygen species therapeutic |
| url | https://www.mdpi.com/2218-273X/15/1/6 |
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