Acetylcholinesterase Inhibitory and Antioxidant Activity of the Compounds Isolated from Vanda roxburghii
Vanda roxburghii has been used in traditional medicine to treat nervous system disorders including Alzheimer’s disease (AD). We reported earlier a high acetylcholinesterase inhibitory and antioxidant activity in the chloroform fraction of this plant. Therefore, this study was designed to explore the...
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Wiley
2021-01-01
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| Series: | Advances in Pharmacological and Pharmaceutical Sciences |
| Online Access: | http://dx.doi.org/10.1155/2021/5569054 |
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| author | Salim Ahammed Rejina Afrin Nasim Uddin Yusuf Al-Amin Kamrul Hasan Uzzal Haque K. M. Monirul Islam A. H. M. K. Alam Toshihisa Tanaka Golam Sadik |
| author_facet | Salim Ahammed Rejina Afrin Nasim Uddin Yusuf Al-Amin Kamrul Hasan Uzzal Haque K. M. Monirul Islam A. H. M. K. Alam Toshihisa Tanaka Golam Sadik |
| author_sort | Salim Ahammed |
| collection | DOAJ |
| description | Vanda roxburghii has been used in traditional medicine to treat nervous system disorders including Alzheimer’s disease (AD). We reported earlier a high acetylcholinesterase inhibitory and antioxidant activity in the chloroform fraction of this plant. Therefore, this study was designed to explore the compounds with acetylcholinesterase inhibitory and antioxidant activities from the chloroform fraction of Vanda roxburghii. Phytochemical investigation led to the isolation for the first time of a fatty acid ester: methyl linoleate (1), and three phenolics: syringaldehyde (2), vanillin (3), and dihydroconiferyl dihydro-p-coumarate (4) along with the previously reported compound gigantol (5). Among the isolates, vanillin (3) and dihydroconiferyl dihydro-p-coumarate (4) were found to significantly inhibit the activity of acetylcholinesterase, scavenge the free radicals, exhibit the reducing power and total antioxidant activity, and effectively reduce the peroxidation of lipid. Gigantol (5) and syringaldehyde (2), despite lacking the activity against acetylcholinesterase, exhibited antioxidant activity. Among the compounds, gigantol (5) appeared to be the most potent antioxidant. These findings revealed that V. roxburghii contained compounds with potential acetylcholinesterase inhibitory and antioxidant activity, which support its traditional use in the treatment of AD. |
| format | Article |
| id | doaj-art-1d4fc9bc51dc4b548aff08ade242da1a |
| institution | Kabale University |
| issn | 2633-4690 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Pharmacological and Pharmaceutical Sciences |
| spelling | doaj-art-1d4fc9bc51dc4b548aff08ade242da1a2025-02-03T01:25:45ZengWileyAdvances in Pharmacological and Pharmaceutical Sciences2633-46902021-01-01202110.1155/2021/55690545569054Acetylcholinesterase Inhibitory and Antioxidant Activity of the Compounds Isolated from Vanda roxburghiiSalim Ahammed0Rejina Afrin1Nasim Uddin2Yusuf Al-Amin3Kamrul Hasan4Uzzal Haque5K. M. Monirul Islam6A. H. M. K. Alam7Toshihisa Tanaka8Golam Sadik9Department of Pharmacy, University of Rajshahi, Rajshahi 6205, BangladeshDepartment of Pharmacy, East West University, Dhaka, BangladeshDepartment of Pharmacy, University of Rajshahi, Rajshahi 6205, BangladeshDepartment of Pharmacy, University of Rajshahi, Rajshahi 6205, BangladeshDepartment of Pharmacy, University of Rajshahi, Rajshahi 6205, BangladeshDepartment of Pharmacy, University of Rajshahi, Rajshahi 6205, BangladeshDepartment of Pharmacy, University of Rajshahi, Rajshahi 6205, BangladeshDepartment of Pharmacy, University of Rajshahi, Rajshahi 6205, BangladeshDepartment of Psychiatry, Osaka University Graduate School of Medicine, Osaka, JapanDepartment of Pharmacy, University of Rajshahi, Rajshahi 6205, BangladeshVanda roxburghii has been used in traditional medicine to treat nervous system disorders including Alzheimer’s disease (AD). We reported earlier a high acetylcholinesterase inhibitory and antioxidant activity in the chloroform fraction of this plant. Therefore, this study was designed to explore the compounds with acetylcholinesterase inhibitory and antioxidant activities from the chloroform fraction of Vanda roxburghii. Phytochemical investigation led to the isolation for the first time of a fatty acid ester: methyl linoleate (1), and three phenolics: syringaldehyde (2), vanillin (3), and dihydroconiferyl dihydro-p-coumarate (4) along with the previously reported compound gigantol (5). Among the isolates, vanillin (3) and dihydroconiferyl dihydro-p-coumarate (4) were found to significantly inhibit the activity of acetylcholinesterase, scavenge the free radicals, exhibit the reducing power and total antioxidant activity, and effectively reduce the peroxidation of lipid. Gigantol (5) and syringaldehyde (2), despite lacking the activity against acetylcholinesterase, exhibited antioxidant activity. Among the compounds, gigantol (5) appeared to be the most potent antioxidant. These findings revealed that V. roxburghii contained compounds with potential acetylcholinesterase inhibitory and antioxidant activity, which support its traditional use in the treatment of AD.http://dx.doi.org/10.1155/2021/5569054 |
| spellingShingle | Salim Ahammed Rejina Afrin Nasim Uddin Yusuf Al-Amin Kamrul Hasan Uzzal Haque K. M. Monirul Islam A. H. M. K. Alam Toshihisa Tanaka Golam Sadik Acetylcholinesterase Inhibitory and Antioxidant Activity of the Compounds Isolated from Vanda roxburghii Advances in Pharmacological and Pharmaceutical Sciences |
| title | Acetylcholinesterase Inhibitory and Antioxidant Activity of the Compounds Isolated from Vanda roxburghii |
| title_full | Acetylcholinesterase Inhibitory and Antioxidant Activity of the Compounds Isolated from Vanda roxburghii |
| title_fullStr | Acetylcholinesterase Inhibitory and Antioxidant Activity of the Compounds Isolated from Vanda roxburghii |
| title_full_unstemmed | Acetylcholinesterase Inhibitory and Antioxidant Activity of the Compounds Isolated from Vanda roxburghii |
| title_short | Acetylcholinesterase Inhibitory and Antioxidant Activity of the Compounds Isolated from Vanda roxburghii |
| title_sort | acetylcholinesterase inhibitory and antioxidant activity of the compounds isolated from vanda roxburghii |
| url | http://dx.doi.org/10.1155/2021/5569054 |
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